Gene Page: SORBS2
Summary ?
| GeneID | 8470 |
| Symbol | SORBS2 |
| Synonyms | ARGBP2|PRO0618 |
| Description | sorbin and SH3 domain containing 2 |
| Reference | MIM:616349|HGNC:HGNC:24098|Ensembl:ENSG00000154556|HPRD:12473|Vega:OTTHUMG00000157215 |
| Gene type | protein-coding |
| Map location | 4q35.1 |
| Pascal p-value | 0.811 |
| Sherlock p-value | 0.006 |
| Fetal beta | 2.763 |
| Support | G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SORBS2 | chr4 | 186544420 | C | A | NM_001145670 NM_001145671 NM_001145672 NM_001145673 NM_001145674 NM_001145675 NM_001270771 NM_003603 NM_021069 | . . . . p.621Q>H . p.817Q>H . p.717Q>H | intronic intronic intronic intronic missense intronic missense intronic missense | Schizophrenia | DNM:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MATK | 0.89 | 0.90 |
| PIN1 | 0.85 | 0.85 |
| FDX1L | 0.85 | 0.88 |
| PARD6A | 0.84 | 0.86 |
| SH3GLB2 | 0.84 | 0.88 |
| ST6GALNAC6 | 0.84 | 0.86 |
| GNG3 | 0.84 | 0.88 |
| KIF12 | 0.83 | 0.76 |
| RPS19BP1 | 0.83 | 0.82 |
| FAM131A | 0.83 | 0.86 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MAP4K4 | -0.52 | -0.52 |
| AC005035.1 | -0.49 | -0.49 |
| GPR125 | -0.48 | -0.48 |
| THOC2 | -0.47 | -0.47 |
| ZNF652 | -0.47 | -0.42 |
| PHF16 | -0.46 | -0.40 |
| FAM107B | -0.46 | -0.40 |
| EIF5B | -0.46 | -0.56 |
| CWF19L2 | -0.45 | -0.59 |
| ATAD2B | -0.45 | -0.42 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | - | HPRD,BioGRID | 9211900 |12475393 |
| ABL2 | ABLL | ARG | FLJ22224 | FLJ31718 | FLJ41441 | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | - | HPRD,BioGRID | 9211900 |
| CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 12475393 |15128873 |
| CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | ArgBP2 interacts with Cbl. | BIND | 15128873 |
| CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | ArgBP2-A interacts with Cbl. | BIND | 12475393 |
| DLGAP1 | DAP-1 | DAP-1-ALPHA | DAP-1-BETA | GKAP | MGC88156 | SAPAP1 | hGKAP | discs, large (Drosophila) homolog-associated protein 1 | - | HPRD,BioGRID | 10521485 |
| DLGAP2 | DAP2 | SAPAP2 | discs, large (Drosophila) homolog-associated protein 2 | - | HPRD | 10521485 |
| DLGAP4 | DAP4 | KIAA0964 | MGC131862 | RP5-977B1.6 | SAPAP4 | discs, large (Drosophila) homolog-associated protein 4 | - | HPRD,BioGRID | 10521485 |
| FLOT1 | - | flotillin 1 | ArgBP2 interacts with flotillin-1. This interaction was modeled on a demonstrated interaction between human ArgBP2 and flotillin-1 from an unspecified species. | BIND | 15128873 |
| FLOT1 | - | flotillin 1 | nArgBP2 interacts with flotillin-1. This interaction was modeled on a demonstrated interaction between rat nArgBP2 and flotillin-1 from an unspecified species. | BIND | 15128873 |
| FLOT1 | - | flotillin 1 | - | HPRD,BioGRID | 15128873 |
| MLLT4 | AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | - | HPRD,BioGRID | 10521485 |
| PKM2 | CTHBP | MGC3932 | OIP3 | PK3 | PKM | TCB | THBP1 | pyruvate kinase, muscle | - | HPRD | 15128873 |
| PTK2B | CADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTK | PTK2B protein tyrosine kinase 2 beta | ArgBP2 interacts with Pyk2. | BIND | 15128873 |
| PTK2B | CADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTK | PTK2B protein tyrosine kinase 2 beta | - | HPRD,BioGRID | 15128873 |
| RPL9 | DKFZp313J1510 | FLJ27456 | MGC15545 | NPC-A-16 | ribosomal protein L9 | Two-hybrid | BioGRID | 16169070 |
| SEMA6A | HT018 | KIAA1368 | SEMA | SEMA6A1 | SEMAQ | VIA | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | - | HPRD | 12421765 |
| SFN | YWHAS | stratifin | Affinity Capture-MS | BioGRID | 15778465 |
| TRAF4 | CART1 | MLN62 | RNF83 | TNF receptor-associated factor 4 | TRAF4 interacts with ArgBP2. | BIND | 12023963 |
| VCL | CMD1W | MVCL | vinculin | - | HPRD,BioGRID | 10521485 |
| YWHAE | 14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDS | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | Two-hybrid | BioGRID | 16189514 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SENGUPTA NASOPHARYNGEAL CARCINOMA DN | 349 | 157 | All SZGR 2.0 genes in this pathway |
| TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN | 198 | 110 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS TOP50 DN | 45 | 26 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LIVE DN | 384 | 220 | All SZGR 2.0 genes in this pathway |
| THUM SYSTOLIC HEART FAILURE DN | 244 | 147 | All SZGR 2.0 genes in this pathway |
| WIKMAN ASBESTOS LUNG CANCER UP | 17 | 11 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | All SZGR 2.0 genes in this pathway |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS GREY DN | 74 | 44 | All SZGR 2.0 genes in this pathway |
| ODONNELL TFRC TARGETS UP | 456 | 228 | All SZGR 2.0 genes in this pathway |
| ODONNELL TARGETS OF MYC AND TFRC UP | 83 | 50 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC1 AND HDAC2 TARGETS UP | 238 | 144 | All SZGR 2.0 genes in this pathway |
| LEE NEURAL CREST STEM CELL DN | 118 | 79 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| DELYS THYROID CANCER DN | 232 | 154 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS E UP | 97 | 60 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| KIM MYC AMPLIFICATION TARGETS DN | 97 | 51 | All SZGR 2.0 genes in this pathway |
| RICKMAN HEAD AND NECK CANCER D | 37 | 14 | All SZGR 2.0 genes in this pathway |
| ASTON MAJOR DEPRESSIVE DISORDER DN | 160 | 110 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER ACOX1 UP | 64 | 40 | All SZGR 2.0 genes in this pathway |
| MANALO HYPOXIA UP | 207 | 145 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| WANG SMARCE1 TARGETS DN | 371 | 218 | All SZGR 2.0 genes in this pathway |
| BANDRES RESPONSE TO CARMUSTIN MGMT 24HR DN | 33 | 21 | All SZGR 2.0 genes in this pathway |
| KAAB HEART ATRIUM VS VENTRICLE DN | 261 | 183 | All SZGR 2.0 genes in this pathway |
| MCLACHLAN DENTAL CARIES DN | 245 | 144 | All SZGR 2.0 genes in this pathway |
| XU GH1 EXOGENOUS TARGETS DN | 120 | 69 | All SZGR 2.0 genes in this pathway |
| BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN | 161 | 105 | All SZGR 2.0 genes in this pathway |
| MARIADASON RESPONSE TO BUTYRATE SULINDAC 6 | 52 | 32 | All SZGR 2.0 genes in this pathway |
| MCCABE BOUND BY HOXC6 | 469 | 239 | All SZGR 2.0 genes in this pathway |
| VICENT METASTASIS UP | 14 | 11 | All SZGR 2.0 genes in this pathway |
| MITSIADES RESPONSE TO APLIDIN UP | 439 | 257 | All SZGR 2.0 genes in this pathway |
| IZADPANAH STEM CELL ADIPOSE VS BONE DN | 108 | 68 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| HUANG DASATINIB RESISTANCE DN | 69 | 44 | All SZGR 2.0 genes in this pathway |
| POOLA INVASIVE BREAST CANCER DN | 134 | 83 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G3 DN | 51 | 32 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN | 179 | 97 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP | 85 | 50 | All SZGR 2.0 genes in this pathway |
| COULOUARN TEMPORAL TGFB1 SIGNATURE DN | 138 | 99 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS UP | 279 | 155 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY LUMINAL PROGENITOR UP | 58 | 30 | All SZGR 2.0 genes in this pathway |