Summary ?
GeneID8493
SymbolPPM1D
SynonymsPP2C-DELTA|WIP1
Descriptionprotein phosphatase, Mg2+/Mn2+ dependent 1D
ReferenceMIM:605100|HGNC:HGNC:9277|Ensembl:ENSG00000170836|HPRD:05482|Vega:OTTHUMG00000180052
Gene typeprotein-coding
Map location17q23.2
Pascal p-value0.043
Fetal beta1.226
DMG2 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg184202981758677512PPM1D4.983E-4-0.2880.047DMG:Wockner_2014
cg106739841758677844PPM1D-0.0260.26DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CUL30.920.91
GPBP10.910.90
YME1L10.900.89
SRP540.900.90
CNOT70.900.90
MSH20.890.88
CUL20.890.89
DNTTIP20.890.89
DDX100.890.88
DENR0.890.88
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.75-0.76
AF347015.33-0.73-0.74
AF347015.8-0.73-0.75
AF347015.31-0.72-0.75
AF347015.2-0.72-0.74
MT-CYB-0.71-0.73
FXYD1-0.71-0.75
AF347015.15-0.71-0.75
AF347015.21-0.70-0.69
AF347015.27-0.70-0.72

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG P53 SIGNALING PATHWAY 6945All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY 5950All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306188All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352225All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN 240171All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
KERLEY RESPONSE TO CISPLATIN UP 4430All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER UP 181108All SZGR 2.0 genes in this pathway
AMUNDSON DNA DAMAGE RESPONSE TP53 169All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149101All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS DN 6441All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344180All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156101All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177132All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242159All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE MIDDLE 9856All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344215All SZGR 2.0 genes in this pathway
MIZUSHIMA AUTOPHAGOSOME FORMATION 1915All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 2HR UP 5333All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP 16697All SZGR 2.0 genes in this pathway
WARTERS RESPONSE TO IR SKIN 8344All SZGR 2.0 genes in this pathway
WARTERS IR RESPONSE 5GY 4723All SZGR 2.0 genes in this pathway
ZWANG DOWN BY 2ND EGF PULSE 293119All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 5 1811All SZGR 2.0 genes in this pathway