Summary ?
GeneID84938
SymbolATG4C
SynonymsAPG4-C|APG4C|AUTL1|AUTL3
Descriptionautophagy related 4C cysteine peptidase
ReferenceMIM:611339|HGNC:HGNC:16040|Ensembl:ENSG00000125703|HPRD:07473|Vega:OTTHUMG00000009142
Gene typeprotein-coding
Map location1p31.3
Pascal p-value0.525
Sherlock p-value0.322
Fetal beta-0.725
eGeneCerebellar Hemisphere
Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.02692 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2322319chr33637199ATG4C849380.11trans
rs17137051chr164521748ATG4C849380.13trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingISS12446702 
GO:0004197cysteine-type endopeptidase activityISS12446702 
GO:0008017microtubule bindingISS12446702 
GO:0008233peptidase activityIDA12446702 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000045autophagic vacuole formationISS12446702 
GO:0006508proteolysisIDA12446702 
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0006623protein targeting to vacuoleISS12446702 
GO:0006914autophagyIGI12446702 
GO:0006612protein targeting to membraneISS12446702 
GO:0015031protein transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolISS12446702 
GO:0005875microtubule associated complexISS12446702 
GO:0005576extracellular regionIDA12446702 
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmISS12446702 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG REGULATION OF AUTOPHAGY 3530All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
GRADE COLON CANCER DN 3322All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO CISPLATIN 2014All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397206All SZGR 2.0 genes in this pathway