Summary ?
Descriptionimmunoglobin superfamily member 21
Gene typeprotein-coding
Map location1p36.13
Pascal p-value4.598E-4
Sherlock p-value0.963
Fetal beta-0.471
DMG2 (# studies)
eGeneCerebellar Hemisphere
Frontal Cortex BA9
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ALDH2ALDH-E2 | ALDHI | ALDM | MGC1806aldehyde dehydrogenase 2 family (mitochondrial)Two-hybridBioGRID16169070 
ANXA3ANX3annexin A3Two-hybridBioGRID16169070 
ATF3-activating transcription factor 3Two-hybridBioGRID16169070 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster regionTwo-hybridBioGRID16169070 
BTBD2-BTB (POZ) domain containing 2Two-hybridBioGRID16169070 
C5orf13D4S114 | P311 | PRO1873 | PTZ17chromosome 5 open reading frame 13Two-hybridBioGRID16169070 
CRCT1C1orf42 | NICE-1cysteine-rich C-terminal 1Two-hybridBioGRID16169070 
DGKDDGKdelta | FLJ26930 | KIAA0145 | dgkd-2diacylglycerol kinase, delta 130kDaTwo-hybridBioGRID16169070 
ERHDROER | FLJ27340enhancer of rudimentary homolog (Drosophila)Two-hybridBioGRID16169070 
ETHE1HSCO | YF13H12ethylmalonic encephalopathy 1Two-hybridBioGRID16169070 
GIPC2FLJ20075 | SEMCAP-2 | SEMCAP2GIPC PDZ domain containing family, member 2Two-hybridBioGRID16169070 
GSTM4GSTM4-4 | GTM4 | MGC131945 | MGC9247glutathione S-transferase mu 4Two-hybridBioGRID16169070 
HSPB1CMT2F | DKFZp586P1322 | HMN2B | HS.76067 | HSP27 | HSP28 | Hsp25 | SRP27heat shock 27kDa protein 1Two-hybridBioGRID16169070 
MAD2L1BPCMT2 | KIAA0110 | MGC11282 | RP1-261G23.6MAD2L1 binding proteinTwo-hybridBioGRID16169070 
NACAHSD48 | MGC117224 | NACA1nascent polypeptide-associated complex alpha subunitTwo-hybridBioGRID16169070 
PAEPGD | GdA | GdF | GdS | MGC138509 | MGC142288 | PAEG | PEP | PP14progestagen-associated endometrial proteinTwo-hybridBioGRID16169070 
PAFAH1B3-platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDaTwo-hybridBioGRID16169070 
PCDHA4CNR1 | CNRN1 | CRNR1 | MGC138307 | MGC142169 | PCDH-ALPHA4protocadherin alpha 4Two-hybridBioGRID16169070 
PRMT1ANM1 | HCP1 | HRMT1L2 | IR1B4protein arginine methyltransferase 1Two-hybridBioGRID16169070 
PSMD11MGC3844 | Rpn6 | S9 | p44.5proteasome (prosome, macropain) 26S subunit, non-ATPase, 11Two-hybridBioGRID16169070 
RPP14FLJ31508 | P14ribonuclease P/MRP 14kDa subunitTwo-hybridBioGRID16169070 
S100A860B8AG | CAGA | CFAG | CGLA | CP-10 | L1Ag | MA387 | MIF | MRP8 | NIF | P8S100 calcium binding protein A8Two-hybridBioGRID16169070 
SEPHS1MGC4980 | SELD | SPS | SPS1selenophosphate synthetase 1Two-hybridBioGRID16169070 
SERPINB9CAP-3 | CAP3 | PI9serpin peptidase inhibitor, clade B (ovalbumin), member 9Two-hybridBioGRID16169070 
SULT1E1EST | EST-1 | MGC34459 | STEsulfotransferase family 1E, estrogen-preferring, member 1Two-hybridBioGRID16169070 
TRBV2TCRBV22S1A2N1T | TCRBV2S1T cell receptor beta variable 2Two-hybridBioGRID16169070 
UBE2V2DDVIT1 | DDVit-1 | EDAF-1 | EDPF-1 | EDPF1 | MMS2 | UEV-2 | UEV2ubiquitin-conjugating enzyme E2 variant 2Two-hybridBioGRID16169070 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
WHITEHURST PACLITAXEL SENSITIVITY 3919All SZGR 2.0 genes in this pathway
HANN RESISTANCE TO BCL2 INHIBITOR DN 4831All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349234All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway