Summary ?
GeneID8500
SymbolPPFIA1
SynonymsLIP.1|LIP1|LIPRIN
DescriptionPTPRF interacting protein alpha 1
ReferenceMIM:611054|HGNC:HGNC:9245|Ensembl:ENSG00000131626|HPRD:11451|Vega:OTTHUMG00000167266
Gene typeprotein-coding
Map location11q13.3
Pascal p-value0.413
Sherlock p-value0.491
Fetal beta-0.135
DMG1 (# studies)
eGeneCerebellar Hemisphere
Cerebellum
Cortex
Myers' cis & trans
SupportPROTEIN CLUSTERING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
CompositeSet
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg126527801170178166PPFIA13.466E-40.3390.041DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
snp_a-18179040PPFIA185000.06trans
rs6494052chr1559295924PPFIA185000.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GPI0.860.83
FAM73B0.850.82
TOM10.850.85
LIMK10.850.82
SNPH0.840.87
ABHD120.840.82
TOM1L20.840.83
SRPR0.840.83
NDRG40.830.84
ACO20.830.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FAM159B-0.44-0.67
C9orf46-0.42-0.45
EXOSC8-0.41-0.37
RPL13AP22-0.41-0.56
FAM36A-0.40-0.36
AC005921.3-0.40-0.43
AC087071.1-0.40-0.38
RP9P-0.40-0.46
AC120053.1-0.39-0.42
RBMX2-0.39-0.37

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ERC1Cast2 | ELKS | KIAA1081 | MGC12974 | RAB6IP2ELKS/RAB6-interacting/CAST family member 1-HPRD12923177 
ERC2CAST | CAST1 | ELKSL | KIAA0378 | MGC133063 | MGC133064 | SPBC110 | Spc110ELKS/RAB6-interacting/CAST family member 2Liprin-alpha1 interacts with ERC2.BIND12923177 
ERC2CAST | CAST1 | ELKSL | KIAA0378 | MGC133063 | MGC133064 | SPBC110 | Spc110ELKS/RAB6-interacting/CAST family member 2-HPRD,BioGRID12923177 
GIT1-G protein-coupled receptor kinase interacting ArfGAP 1Liprin-alpha1 interacts with GIT1. This interaction was modeled on a demonstrated interaction between human liprin-alpha1 and rat GIT1.BIND12923177 
GIT1-G protein-coupled receptor kinase interacting ArfGAP 1-HPRD,BioGRID12629171 
GRIP2-glutamate receptor interacting protein 2Affinity Capture-WesternBioGRID12629171 |12923177 
MBIP-MAP3K12 binding inhibitory protein 1Two-hybridBioGRID16189514 
NCOA2GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2nuclear receptor coactivator 2-HPRD,BioGRID11931740 
PPFIA2FLJ41378 | MGC132572protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2-HPRD,BioGRID9624153 
PPFIA3KIAA0654 | LPNA3 | MGC126567 | MGC126569protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3-HPRD,BioGRID9624153 
PPFIBP1L2 | hSGT2 | hSgt2pPTPRF interacting protein, binding protein 1 (liprin beta 1)-HPRD,BioGRID9624153 
PPFIBP2Cclp1 | DKFZp781K06126 | MGC42541PTPRF interacting protein, binding protein 2 (liprin beta 2)-HPRD,BioGRID9624153 
PPP2CAPP2Ac | PP2CA | RP-Cprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformAffinity Capture-MSBioGRID18782753 
PPP2R1AMGC786 | PR65Aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoformAffinity Capture-MSBioGRID18782753 
PPP2R5DB56D | MGC2134 | MGC8949protein phosphatase 2, regulatory subunit B', delta isoformAffinity Capture-Western
Two-hybrid
BioGRID16189514 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, C-HPRD,BioGRID9624153 
PTPRDHPTP | HPTP-DELTA | HPTPD | MGC119750 | MGC119751 | MGC119752 | MGC119753 | PTPD | R-PTP-DELTAprotein tyrosine phosphatase, receptor type, D-HPRD,BioGRID8524829 
PTPRFFLJ43335 | FLJ45062 | FLJ45567 | LARprotein tyrosine phosphatase, receptor type, F-HPRD8524829 |9624153 
PTPRFFLJ43335 | FLJ45062 | FLJ45567 | LARprotein tyrosine phosphatase, receptor type, F-HPRD,BioGRID7796809 |8524829 
|9624153|8524829 |9624153 
PTPRSPTPSIGMAprotein tyrosine phosphatase, receptor type, S-HPRD,BioGRID8524829 
TNNT1ANM | FLJ98147 | MGC104241 | STNT | TNT | TNTStroponin T type 1 (skeletal, slow)Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
LIU SOX4 TARGETS DN 309191All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352225All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR DN 8853All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
JAERVINEN AMPLIFIED IN LARYNGEAL CANCER 4024All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483336All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214139All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON 15893All SZGR 2.0 genes in this pathway
DING LUNG CANCER EXPRESSION BY COPY NUMBER 10062All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225139All SZGR 2.0 genes in this pathway
SU TESTIS 7653All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD DN 15093All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 10573All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY DN 14588All SZGR 2.0 genes in this pathway
KIM GASTRIC CANCER CHEMOSENSITIVITY 10364All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156101All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178111All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463262All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS UP 6336All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456285All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA 4327All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS UP 7445All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP 11687All SZGR 2.0 genes in this pathway