Gene Page: MAPKAPK5
Summary ?
| GeneID | 8550 |
| Symbol | MAPKAPK5 |
| Synonyms | MAPKAP-K5|MK-5|MK5|PRAK |
| Description | mitogen-activated protein kinase-activated protein kinase 5 |
| Reference | MIM:606723|HGNC:HGNC:6889|HPRD:09467| |
| Gene type | protein-coding |
| Map location | 12q24.13 |
| Pascal p-value | 0.223 |
| Sherlock p-value | 0.254 |
| Fetal beta | 0.364 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg22778180 | 12 | 112280887 | MAPKAPK5 | 2.45E-8 | -0.008 | 7.94E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4491879 | chr3 | 189373908 | MAPKAPK5 | 8550 | 0.08 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ATF2 | CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7 | activating transcription factor 2 | - | HPRD | 9628874 |
| EIF4E | CBP | EIF4E1 | EIF4EL1 | EIF4F | MGC111573 | eukaryotic translation initiation factor 4E | - | HPRD | 9628874 |
| EIF4EBP1 | 4E-BP1 | 4EBP1 | BP-1 | MGC4316 | PHAS-I | eukaryotic translation initiation factor 4E binding protein 1 | - | HPRD | 9628874 |
| HSPB1 | CMT2F | DKFZp586P1322 | HMN2B | HS.76067 | HSP27 | HSP28 | Hsp25 | SRP27 | heat shock 27kDa protein 1 | - | HPRD,BioGRID | 9628874 |
| HSPB2 | HSP27 | Hs.78846 | LOH11CR1K | MGC133245 | MKBP | heat shock 27kDa protein 2 | Biochemical Activity | BioGRID | 9628874 |
| JUN | AP-1 | AP1 | c-Jun | jun oncogene | - | HPRD | 9628874 |
| MAPK1 | ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapk | mitogen-activated protein kinase 1 | - | HPRD | 9628874 |
| MAPK12 | ERK3 | ERK6 | P38GAMMA | PRKM12 | SAPK-3 | SAPK3 | mitogen-activated protein kinase 12 | - | HPRD | 9628874 |
| MAPK13 | MGC99536 | PRKM13 | SAPK4 | p38delta | mitogen-activated protein kinase 13 | - | HPRD | 9628874 |
| MAPK9 | JNK-55 | JNK2 | JNK2A | JNK2ALPHA | JNK2B | JNK2BETA | PRKM9 | SAPK | p54a | p54aSAPK | mitogen-activated protein kinase 9 | - | HPRD | 9628874 |
| MBP | MGC99675 | myelin basic protein | - | HPRD | 9628874 |
| MYH11 | AAT4 | DKFZp686D10126 | DKFZp686D19237 | FAA4 | FLJ35232 | MGC126726 | MGC32963 | SMHC | SMMHC | myosin, heavy chain 11, smooth muscle | - | HPRD | 9628874 |
| PLA2G4A | MGC126350 | PLA2G4 | cPLA2-alpha | phospholipase A2, group IVA (cytosolic, calcium-dependent) | PRAK1 phosphorylates cPLA2. | BIND | 10978317 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG MAPK SIGNALING PATHWAY | 267 | 205 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MAPK PATHWAY | 87 | 68 | All SZGR 2.0 genes in this pathway |
| BIOCARTA P38MAPK PATHWAY | 40 | 31 | All SZGR 2.0 genes in this pathway |
| SIG CD40PATHWAYMAP | 34 | 28 | All SZGR 2.0 genes in this pathway |
| ST P38 MAPK PATHWAY | 37 | 28 | All SZGR 2.0 genes in this pathway |
| PID P38 ALPHA BETA DOWNSTREAM PATHWAY | 38 | 29 | All SZGR 2.0 genes in this pathway |
| BIDUS METASTASIS UP | 214 | 134 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE DN | 485 | 334 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RESPONSE TO TRABECTEDIN DN | 271 | 175 | All SZGR 2.0 genes in this pathway |
| CAMPS COLON CANCER COPY NUMBER UP | 92 | 45 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | 456 | 285 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES UP | 605 | 377 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 30MIN DN | 150 | 99 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |