Gene Page: MADD

Summary ?
GeneID8567
SymbolMADD
SynonymsDENN|IG20|RAB3GEP
DescriptionMAP kinase activating death domain
ReferenceMIM:603584|HGNC:HGNC:6766|Ensembl:ENSG00000110514|HPRD:04664|Vega:OTTHUMG00000150350
Gene typeprotein-coding
Map location11p11.2
Pascal p-value0.029
Sherlock p-value0.622
Fetal beta-0.801
eGeneCerebellar Hemisphere
Cerebellum
Meta
SupportCompositeSet
Darnell FMRP targets
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MRPL230.850.78
C11orf830.850.81
C19orf600.850.75
POLR2L0.840.74
POLR2I0.840.74
MRPS110.840.73
LAGE30.830.74
LSM100.830.76
NME30.820.73
DGCR6L0.820.76
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.26-0.37-0.36
AF347015.15-0.36-0.38
AF347015.2-0.34-0.32
MT-ATP8-0.34-0.38
AF347015.8-0.34-0.35
AF347015.18-0.33-0.30
MT-CYB-0.33-0.36
AF347015.33-0.32-0.35
AF347015.27-0.32-0.37
SDPR-0.31-0.29

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA TNFR1 PATHWAY 2921All SZGR 2.0 genes in this pathway
PID TNF PATHWAY 4633All SZGR 2.0 genes in this pathway
PID CERAMIDE PATHWAY 4837All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY 5239All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180101All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229142All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER UP 10075All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
LEIN NEURON MARKERS 6945All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 12081All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225124All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN 14690All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL DN 214124All SZGR 2.0 genes in this pathway