Gene Page: TNFSF11

Summary
GeneID  8600
Symbol  TNFSF11
Synonyms  CD254|ODF|OPGL|OPTB2|RANKL|TRANCE|hRANKL2|sOdf
Description  tumor necrosis factor (ligand) superfamily, member 11
See related  HGNC:11926|MIM:602642|Ensembl:ENSG00000120659|HPRD:04031|
Locus tag  -
Gene type  protein-coding
Map location  13q14
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0312 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DNAJB60.920.89
SUMO10.900.83
SSB0.890.87
CBX30.880.85
DENR0.880.84
DNTTIP20.880.84
FIP1L10.870.87
YWHAE0.870.83
SNX40.870.81
RALA0.870.87
Top 10 negatively co-expressed genes
TREX1-0.62-0.73
HLA-F-0.62-0.70
FXYD1-0.61-0.70
TSC22D4-0.60-0.70
MT-CO2-0.60-0.68
AC018755.7-0.60-0.66
AF347015.33-0.59-0.68
IFI27-0.59-0.70
AF347015.9-0.59-0.72
AF347015.31-0.58-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0005125cytokine activityNAS9568710 
GO:0005164tumor necrosis factor receptor bindingNAS9312132 |9367155 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006955immune responseNAS9312132 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0045780positive regulation of bone resorptionIDA17241109 
GO:0045672positive regulation of osteoclast differentiationIDA17241109 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS9568710 |10708588 
GO:0005615extracellular spaceIEA-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneNAS9312132 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1-HPRD10635328 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1Biochemical ActivityBioGRID10635328 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1-HPRD10635328 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3-HPRD10635328 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8-HPRD9396779 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1-HPRD10635328 
NFKBIAIKBA | MAD-3 | NFKBInuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha-HPRD10635328 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Affinity Capture-WesternBioGRID10635328 
TNFRSF11ACD265 | FEO | LOH18CR1 | ODFR | OFE | OPTB7 | OSTS | PDB2 | RANK | TRANCERtumor necrosis factor receptor superfamily, member 11a, NFKB activator-HPRD9367155 
TNFRSF11BMGC29565 | OCIF | OPG | TR1tumor necrosis factor receptor superfamily, member 11b-HPRD,BioGRID9520411|12221720 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6-HPRD10635328 
ZNF675FLJ36350 | TBZF | TIZzinc finger protein 675Phenotypic SuppressionBioGRID11751921 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
BIOCARTA_RANKL_PATHWAY 1413All SZGR genes in this pathway
PID_IL6_7_PATHWAY 4740All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN 349157All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_DN 12986All SZGR genes in this pathway
AFFAR_YY1_TARGETS_DN 234137All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
SAFFORD_T_LYMPHOCYTE_ANERGY 8754All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_THYMUS_UP 196137All SZGR genes in this pathway
WORSCHECH_TUMOR_REJECTION_UP 5632All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME2_AND_H3K27ME3 5935All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_DN 5438All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_DN 157106All SZGR genes in this pathway
FUKUSHIMA_TNFSF11_TARGETS 1614All SZGR genes in this pathway
CARD_MIR302A_TARGETS 7762All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_UP 11665All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/506801807m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-17-5p/20/93.mr/106/519.d617623m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-18110491055m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1943984041Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-4104634691Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
hsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-493-5p594600m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-543105010571A,m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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