Gene Page: RUVBL1
Summary ?
| GeneID | 8607 |
| Symbol | RUVBL1 |
| Synonyms | ECP-54|ECP54|INO80H|NMP 238|NMP238|PONTIN|Pontin52|RVB1|TIH1|TIP49|TIP49A |
| Description | RuvB like AAA ATPase 1 |
| Reference | MIM:603449|HGNC:HGNC:10474|Ensembl:ENSG00000175792|HPRD:09143|Vega:OTTHUMG00000159658 |
| Gene type | protein-coding |
| Map location | 3q21 |
| Pascal p-value | 0.003 |
| Sherlock p-value | 0.914 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6812324 | chr4 | 157991591 | RUVBL1 | 8607 | 0.06 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LEF1 | 0.54 | 0.31 |
| ANO2 | 0.53 | 0.26 |
| OTX2 | 0.52 | 0.16 |
| KLK10 | 0.52 | 0.20 |
| TRH | 0.50 | 0.01 |
| ANXA3 | 0.50 | 0.28 |
| EPHA1 | 0.49 | 0.15 |
| GPR177 | 0.49 | 0.25 |
| PODNL1 | 0.49 | 0.23 |
| PDE5A | 0.48 | 0.23 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| GNRHR | -0.26 | -0.31 |
| LMO7 | -0.26 | -0.22 |
| ELMOD1 | -0.25 | -0.19 |
| DNAJC2 | -0.24 | -0.24 |
| NOVA1 | -0.24 | -0.23 |
| AC022692.2 | -0.23 | -0.20 |
| ARHGAP20 | -0.23 | -0.17 |
| UPF2 | -0.23 | -0.17 |
| DPP4 | -0.22 | -0.23 |
| GTDC1 | -0.22 | -0.16 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ACTL6A | ACTL6 | Arp4 | BAF53A | INO80K | MGC5382 | actin-like 6A | - | HPRD,BioGRID | 11839798 |
| C19orf2 | FLJ10575 | NNX3 | RMP | URI | chromosome 19 open reading frame 2 | - | HPRD | 14615539 |
| C20orf20 | Eaf7 | FLJ10914 | MRG15BP | MRGBP | URCC4 | chromosome 20 open reading frame 20 | - | HPRD | 12963728 |
| C2orf44 | FLJ21945 | PP384 | chromosome 2 open reading frame 44 | Affinity Capture-MS | BioGRID | 17353931 |
| CD82 | 4F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27 | CD82 molecule | RUVBL1 (pontin) interacts with the CD82 (KAI1) promoter. | BIND | 15829968 |
| CTNNB1 | CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 | catenin (cadherin-associated protein), beta 1, 88kDa | Affinity Capture-Western Reconstituted Complex | BioGRID | 9843967 |
| DNASE2 | DNASE2A | DNL | DNL2 | deoxyribonuclease II, lysosomal | Affinity Capture-MS | BioGRID | 17353931 |
| E2F7 | FLJ12981 | E2F transcription factor 7 | Affinity Capture-MS | BioGRID | 17353931 |
| EP400 | CAGH32 | DKFZP434I225 | FLJ42018 | FLJ45115 | P400 | TNRC12 | E1A binding protein p400 | Affinity Capture-MS Affinity Capture-Western Reconstituted Complex | BioGRID | 11509179 |
| FDFT1 | DGPT | ERG9 | SQS | SS | farnesyl-diphosphate farnesyltransferase 1 | Affinity Capture-MS | BioGRID | 17353931 |
| GNAS | AHO | C20orf45 | GNAS1 | GPSA | GSA | GSP | MGC33735 | PHP1A | PHP1B | POH | dJ309F20.1.1 | dJ806M20.3.3 | GNAS complex locus | Affinity Capture-MS | BioGRID | 17353931 |
| HLA-B | AS | HLA-B-7301 | HLA-B73 | HLAB | HLAC | SPDA1 | major histocompatibility complex, class I, B | Affinity Capture-MS | BioGRID | 17353931 |
| KAT5 | ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2 | K(lysine) acetyltransferase 5 | HTATIP (Tip60) interacts with RUVBL1 (pontin). | BIND | 15829968 |
| KIAA1377 | - | KIAA1377 | Two-hybrid | BioGRID | 16169070 |
| KLK3 | APS | KLK2A1 | PSA | hK3 | kallikrein-related peptidase 3 | RUVBL1 (pontin) interacts with the KLK3 (PSA) promoter. | BIND | 15829968 |
| LEF1 | DKFZp586H0919 | TCF1ALPHA | lymphoid enhancer-binding factor 1 | Affinity Capture-Western | BioGRID | 9843967 |
| MAP3K7 | TAK1 | TGF1a | mitogen-activated protein kinase kinase kinase 7 | - | HPRD | 14743216 |
| MAP3K7IP2 | FLJ21885 | KIAA0733 | TAB2 | mitogen-activated protein kinase kinase kinase 7 interacting protein 2 | - | HPRD | 14743216 |
| MYC | bHLHe39 | c-Myc | v-myc myelocytomatosis viral oncogene homolog (avian) | Affinity Capture-Western Co-purification Reconstituted Complex | BioGRID | 11509179 |11839798 |
| NOP5/NOP58 | HSPC120 | nucleolar protein NOP5/NOP58 | - | HPRD | 12417735 |
| PELO | CGI-17 | PRO1770 | pelota homolog (Drosophila) | Affinity Capture-MS | BioGRID | 17353931 |
| PSTPIP1 | CD2BP1 | CD2BP1L | CD2BP1S | H-PIP | PAPAS | PSTPIP | proline-serine-threonine phosphatase interacting protein 1 | Affinity Capture-MS | BioGRID | 17353931 |
| RP11-529I10.4 | DKFZp566F084 | deleted in a mouse model of primary ciliary dyskinesia | Affinity Capture-MS | BioGRID | 17353931 |
| RUVBL2 | CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49B | RuvB-like 2 (E. coli) | Affinity Capture-MS | BioGRID | 17353931 |
| SMARCA2 | BAF190 | BRM | FLJ36757 | MGC74511 | SNF2 | SNF2L2 | SNF2LA | SWI2 | Sth1p | hBRM | hSNF2a | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | Co-fractionation | BioGRID | 11839798 |
| SMNDC1 | SMNR | SPF30 | survival motor neuron domain containing 1 | Affinity Capture-MS | BioGRID | 17353931 |
| STAP1 | BRDG1 | STAP-1 | signal transducing adaptor family member 1 | Affinity Capture-MS | BioGRID | 14615539 |
| TBP | GTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIID | TATA box binding protein | Reconstituted Complex | BioGRID | 9843967 |
| TRRAP | FLJ10671 | PAF350/400 | PAF400 | STAF40 | TR-AP | Tra1 | transformation/transcription domain-associated protein | Affinity Capture-Western | BioGRID | 11839798 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG WNT SIGNALING PATHWAY | 151 | 112 | All SZGR 2.0 genes in this pathway |
| PID MYC ACTIV PATHWAY | 79 | 62 | All SZGR 2.0 genes in this pathway |
| PID ILK PATHWAY | 45 | 32 | All SZGR 2.0 genes in this pathway |
| PID MYC PATHWAY | 25 | 22 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE | 421 | 253 | All SZGR 2.0 genes in this pathway |
| REACTOME CHROMOSOME MAINTENANCE | 122 | 80 | All SZGR 2.0 genes in this pathway |
| REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | 64 | 43 | All SZGR 2.0 genes in this pathway |
| REACTOME TELOMERE MAINTENANCE | 75 | 57 | All SZGR 2.0 genes in this pathway |
| REACTOME EXTENSION OF TELOMERES | 27 | 17 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE EPIDERMIS UP | 293 | 179 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE DN | 485 | 334 | All SZGR 2.0 genes in this pathway |
| MATTIOLI MGUS VS PCL | 116 | 62 | All SZGR 2.0 genes in this pathway |
| MATTIOLI MULTIPLE MYELOMA SUBGROUPS | 16 | 7 | All SZGR 2.0 genes in this pathway |
| MOHANKUMAR TLX1 TARGETS UP | 414 | 287 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES 1 | 379 | 235 | All SZGR 2.0 genes in this pathway |
| MANALO HYPOXIA DN | 289 | 166 | All SZGR 2.0 genes in this pathway |
| MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
| HESS TARGETS OF HOXA9 AND MEIS1 UP | 65 | 44 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| GAVIN FOXP3 TARGETS CLUSTER T7 | 98 | 63 | All SZGR 2.0 genes in this pathway |
| SANSOM WNT PATHWAY REQUIRE MYC | 58 | 43 | All SZGR 2.0 genes in this pathway |
| MUELLER PLURINET | 299 | 189 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| CHANG CORE SERUM RESPONSE UP | 212 | 128 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH T 9 11 TRANSLOCATION | 130 | 87 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES UP | 605 | 377 | All SZGR 2.0 genes in this pathway |
| WONG EMBRYONIC STEM CELL CORE | 335 | 193 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17 | 181 | 101 | All SZGR 2.0 genes in this pathway |
| MARTENS BOUND BY PML RARA FUSION | 456 | 287 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN | 374 | 217 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS UP | 295 | 155 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 6HR UP | 229 | 149 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS VIA AKT1 UP | 281 | 183 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS DN | 553 | 343 | All SZGR 2.0 genes in this pathway |
| YUAN ZNF143 PARTNERS | 22 | 15 | All SZGR 2.0 genes in this pathway |
| ALFANO MYC TARGETS | 239 | 156 | All SZGR 2.0 genes in this pathway |