Gene Page: RUNX1T1

Summary ?
GeneID862
SymbolRUNX1T1
SynonymsAML1-MTG8|AML1T1|CBFA2T1|CDR|ETO|MTG8|ZMYND2
Descriptionrunt related transcription factor 1; translocated to, 1 (cyclin D related)
ReferenceMIM:133435|HGNC:HGNC:1535|Ensembl:ENSG00000079102|HPRD:00590|Vega:OTTHUMG00000164066
Gene typeprotein-coding
Map location8q22
Pascal p-value0.698
Sherlock p-value0.024
Fetal beta3.241
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg00045118893076177RUNX1T12.381E-40.4380.037DMG:Wockner_2014
cg11043251893108262RUNX1T15.174E-40.4440.047DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17686978chr893725522RUNX1T18620.13cis
rs16829545chr2151977407RUNX1T18620.12trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI3NESH | SSH3BP3ABI family, member 3Two-hybridBioGRID16189514 
C19orf57MGC11271 | MGC149720chromosome 19 open reading frame 57Two-hybridBioGRID16189514 
CBFA2T2DKFZp313F2116 | EHT | MTGR1 | ZMYND3core-binding factor, runt domain, alpha subunit 2; translocated to, 2ETO interacts with MTGR1.BIND15333839 
CBFA2T2DKFZp313F2116 | EHT | MTGR1 | ZMYND3core-binding factor, runt domain, alpha subunit 2; translocated to, 2-HPRD10675041 
CBFA2T2DKFZp313F2116 | EHT | MTGR1 | ZMYND3core-binding factor, runt domain, alpha subunit 2; translocated to, 2Affinity Capture-WesternBioGRID12242670 |14703694 
|16189514 
CBFA2T3ETO2 | MTG16 | MTGR2 | ZMYND4core-binding factor, runt domain, alpha subunit 2; translocated to, 3-HPRD,BioGRID14703694 
CEP170LFAM68B | KIAA0470 | KIAA0470L | MGC26143centrosomal protein 170kDa-likeTwo-hybridBioGRID16189514 
GFI1FLJ94509 | GFI-1 | ZNF163growth factor independent 1 transcription repressor-HPRD,BioGRID12874834 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Affinity Capture-WesternBioGRID11533236 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1ETO interacts with HDAC1.BIND15333839 
HDAC2RPD3 | YAF1histone deacetylase 2Affinity Capture-WesternBioGRID11533236 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3Affinity Capture-WesternBioGRID11533236 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3ETO interacts with HDAC3.BIND15333839 
HDAC8HDACL1 | RPD3histone deacetylase 8-HPRD,BioGRID11533236 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD10076566 
KPNA1IPOA5 | NPI-1 | RCH2 | SRP1karyopherin alpha 1 (importin alpha 5)-HPRD,BioGRID10951564 
KPNB1IMB1 | IPOB | Impnb | MGC2155 | MGC2156 | MGC2157 | NTF97karyopherin (importin) beta 1-HPRD,BioGRID10951564 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1-HPRD,BioGRID11113190 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1ETO interacts with N-CoR.BIND15333839 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2-HPRD,BioGRID11113190 
NECAB2EFCBP2N-terminal EF-hand calcium binding protein 2Two-hybridBioGRID16189514 
OTUD4DKFZp434I0721 | DUBA6 | HIN1 | HSHIN1 | KIAA1046OTU domain containing 4Affinity Capture-MSBioGRID17353931 
PRKAR2AMGC3606 | PKR2 | PRKAR2protein kinase, cAMP-dependent, regulatory, type II, alpha-HPRD,BioGRID11593431 
RUNX1T1AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2runt-related transcription factor 1; translocated to, 1 (cyclin D-related)-HPRD,BioGRID11113190 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)-HPRD,BioGRID11150306 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)ETO interacts with Sin3A.BIND15333839 
TAF9BDN-7 | DN7 | TAF9L | TAFII31L | TFIID-31TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDaTwo-hybridBioGRID16189514 
TCF12HEB | HTF4 | HsT17266 | bHLHb20transcription factor 12ETO interacts with HEBa. This interaction was modeled on a demonstrated interaction between ETO and HEBb.BIND15333839 
TCF12HEB | HTF4 | HsT17266 | bHLHb20transcription factor 12ETO interacts with HEBb.BIND15333839 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)ETO interacts with E2A.BIND15333839 
TCF4E2-2 | ITF2 | MGC149723 | MGC149724 | PTHS | SEF2 | SEF2-1 | SEF2-1A | SEF2-1B | bHLHb19transcription factor 4ETO interacts with E2-2.BIND15333839 
THRAP3FLJ22082 | MGC133082 | MGC133083 | TRAP150thyroid hormone receptor associated protein 3Affinity Capture-MSBioGRID17353931 
VDRNR1I1vitamin D (1,25- dihydroxyvitamin D3) receptorAffinity Capture-Western
Reconstituted Complex		BioGRID12460926 
WBP11DKFZp779M1063 | NPWBP | SIPP1WW domain binding protein 11Two-hybridBioGRID16189514 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16-HPRD,BioGRID10688654 |11090081 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA 6047All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE DN 6135All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS GREY DN 7444All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 12686All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242165All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281186All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162116All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL UP 14699All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199124All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
DUNNE TARGETS OF AML1 MTG8 FUSION DN 1917All SZGR 2.0 genes in this pathway
WONG ENDMETRIUM CANCER DN 8253All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION HEMGN 3121All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN 193112All SZGR 2.0 genes in this pathway
DAWSON METHYLATED IN LYMPHOMA TCL1 5945All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC 3525All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON 13282All SZGR 2.0 genes in this pathway
ROSS ACUTE MYELOID LEUKEMIA CBF 8257All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
WONG IFNA2 RESISTANCE DN 3420All SZGR 2.0 genes in this pathway
ROSS AML WITH AML1 ETO FUSION 7655All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING DN 6844All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246180All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191131All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR DN 10170All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION DN 5430All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 0HR 6348All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR DN 10164All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER WITH H3K27ME3 19693All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210124All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER POOR SURVIVAL UP 3122All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264159All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293203All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 13 3020All SZGR 2.0 genes in this pathway
VALK AML WITH T 8 21 TRANSLOCATION 55All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222147All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254158All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING 243155All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244157All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182108All SZGR 2.0 genes in this pathway