Summary ?
GeneID863
SymbolCBFA2T3
SynonymsETO2|MTG16|MTGR2|ZMYND4
Descriptioncore-binding factor, runt domain, alpha subunit 2; translocated to, 3
ReferenceMIM:603870|HGNC:HGNC:1537|Ensembl:ENSG00000129993|HPRD:04847|Vega:OTTHUMG00000137864
Gene typeprotein-coding
Map location16q24
Pascal p-value0.033
Sherlock p-value0.257
Fetal beta0.973
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg057513101688963738CBFA2T35.104E-4-0.2880.047DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs65433650CBFA2T38630.19trans
rs16829545chr2151977407CBFA2T38637.901E-8trans
rs7584986chr2184111432CBFA2T38634.68E-5trans
rs6741060chr2217169088CBFA2T38630.09trans
rs17762315chr576807576CBFA2T38630.07trans
rs4836433chr5128361954CBFA2T38630.06trans
rs16955618chr1529937543CBFA2T38636.19E-13trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
EIF2C20.950.94
CRKRS0.920.93
AFF40.920.96
PCNX0.910.95
DCP1A0.910.91
KIF1B0.910.95
SLC12A60.910.93
SEC16A0.900.90
HELZ0.900.94
KIAA16320.900.93
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FXYD1-0.61-0.76
AF347015.31-0.60-0.75
HIGD1B-0.60-0.76
MT-CO2-0.60-0.75
IFI27-0.59-0.74
AF347015.33-0.57-0.69
CXCL14-0.57-0.73
S100B-0.56-0.68
MT-CYB-0.56-0.70
C5orf53-0.56-0.62

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CBFA2T2DKFZp313F2116 | EHT | MTGR1 | ZMYND3core-binding factor, runt domain, alpha subunit 2; translocated to, 2-HPRD,BioGRID12242670 
CBFA2T3ETO2 | MTG16 | MTGR2 | ZMYND4core-binding factor, runt domain, alpha subunit 2; translocated to, 3-HPRD14703694 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD,BioGRID12242670 
HDAC2RPD3 | YAF1histone deacetylase 2Affinity Capture-WesternBioGRID11533236 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3-HPRD,BioGRID12242670 
HDAC6FLJ16239 | HD6 | JM21histone deacetylase 6Affinity Capture-WesternBioGRID11533236 
HDAC8HDACL1 | RPD3histone deacetylase 8Affinity Capture-WesternBioGRID11533236 
LDB1CLIM2 | NLILIM domain binding 1Affinity Capture-WesternBioGRID16407974 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1Affinity Capture-WesternBioGRID11533236 
PRKAR2AMGC3606 | PKR2 | PRKAR2protein kinase, cAMP-dependent, regulatory, type II, alpha-HPRD,BioGRID11823486 
RUNX1AML1 | AML1-EVI-1 | AMLCR1 | CBFA2 | EVI-1 | PEBP2aBrunt-related transcription factor 1-HPRD14703694 
RUNX1T1AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2runt-related transcription factor 1; translocated to, 1 (cyclin D-related)-HPRD,BioGRID14703694 
TAL1SCL | TCL5 | bHLHa17 | tal-1T-cell acute lymphocytic leukemia 1Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
BioGRID16407974 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)Affinity Capture-Western
Reconstituted Complex
BioGRID16407974 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID ERBB4 PATHWAY 3832All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372227All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187115All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
AUNG GASTRIC CANCER 5420All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 13493All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 16Q24 AMPLICON 5338All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS 6648All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE UP 6042All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS UP 4834All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN 12986All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN 178121All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353226All SZGR 2.0 genes in this pathway
OSADA ASCL1 TARGETS UP 4630All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
WU ALZHEIMER DISEASE UP 148All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3 14280All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 15099All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 11674All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211131All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281183All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
HOLLEMAN VINCRISTINE RESISTANCE ALL UP 2716All SZGR 2.0 genes in this pathway