Gene Page: SKAP1

Summary ?
GeneID8631
SymbolSKAP1
SynonymsHEL-S-81p|SCAP1|SKAP55
Descriptionsrc kinase associated phosphoprotein 1
ReferenceMIM:604969|HGNC:HGNC:15605|Ensembl:ENSG00000141293|HPRD:05396|Vega:OTTHUMG00000178823
Gene typeprotein-coding
Map location17q21.32
Pascal p-value0.006
Fetal beta0.527
DMG1 (# studies)
eGeneCaudate basal ganglia

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg195851031746507549SKAP12.95E-4-0.4460.039DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZNF4740.830.34
DNAI10.820.40
MNS10.820.28
TEX90.800.35
NUP62CL0.800.44
C12orf550.800.38
TMEM670.790.30
DZIP1L0.790.39
C12orf630.780.38
CCDC400.780.30
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MGLL-0.31-0.34
EPB49-0.31-0.37
CHN1-0.30-0.32
BCL2L2-0.30-0.32
SNCB-0.30-0.40
TUBA1-0.30-0.34
CBX7-0.29-0.32
CAP2-0.29-0.47
RUNDC3A-0.29-0.37
ADAP1-0.29-0.34

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206111All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
LI CISPLATIN RESISTANCE DN 3520All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION UP 7451All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY UV 6243All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469239All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274165All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway