Gene Page: NUMB
Summary ?
| GeneID | 8650 |
| Symbol | NUMB |
| Synonyms | C14orf41|S171|c14_5527 |
| Description | numb homolog (Drosophila) |
| Reference | MIM:603728|HGNC:HGNC:8060|Ensembl:ENSG00000133961|HPRD:04767|Vega:OTTHUMG00000171436 |
| Gene type | protein-coding |
| Map location | 14q24.3 |
| Pascal p-value | 0.015 |
| Sherlock p-value | 0.454 |
| Fetal beta | 1.558 |
| eGene | Meta |
| Support | G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS Potential synaptic genes |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MYL6 | 0.88 | 0.87 |
| SURF2 | 0.87 | 0.88 |
| INO80E | 0.87 | 0.90 |
| TIMM13 | 0.85 | 0.83 |
| LENG1 | 0.85 | 0.87 |
| C11orf48 | 0.85 | 0.81 |
| POLR2F | 0.85 | 0.85 |
| DRAP1 | 0.85 | 0.89 |
| CCDC12 | 0.85 | 0.85 |
| CCDC107 | 0.83 | 0.79 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.9 | -0.57 | -0.69 |
| AF347015.2 | -0.56 | -0.65 |
| AF347015.33 | -0.56 | -0.63 |
| MT-CYB | -0.56 | -0.63 |
| MT-CO2 | -0.56 | -0.61 |
| AF347015.31 | -0.55 | -0.62 |
| AF347015.26 | -0.54 | -0.64 |
| AF347015.15 | -0.53 | -0.63 |
| AF347015.8 | -0.52 | -0.60 |
| AF347015.27 | -0.52 | -0.63 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AP2A1 | ADTAA | AP2-ALPHA | CLAPA1 | adaptor-related protein complex 2, alpha 1 subunit | - | HPRD,BioGRID | 12942088 |
| APP | AAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2 | amyloid beta (A4) precursor protein | - | HPRD | 12011466 |
| DPYSL2 | CRMP2 | DHPRP2 | DRP-2 | DRP2 | dihydropyrimidinase-like 2 | - | HPRD,BioGRID | 11121447 |12942088 |
| EPS15 | AF-1P | AF1P | MLLT5 | epidermal growth factor receptor pathway substrate 15 | The EH domain of Eps15 interacts with the NPF motif of NUMB. | BIND | 9303539 |
| EPS15 | AF-1P | AF1P | MLLT5 | epidermal growth factor receptor pathway substrate 15 | - | HPRD | 9303539 |
| ITCH | AIF4 | AIP4 | NAPP1 | dJ468O1.1 | itchy E3 ubiquitin protein ligase homolog (mouse) | - | HPRD,BioGRID | 12682059 |
| L1CAM | CAML1 | CD171 | HSAS | HSAS1 | MASA | MIC5 | N-CAML1 | S10 | SPG1 | L1 cell adhesion molecule | - | HPRD,BioGRID | 12942088 |
| LNX1 | LNX | MPDZ | PDZRN2 | ligand of numb-protein X 1 | - | HPRD,BioGRID | 9535908 |11782429 |
| LNX2 | FLJ12933 | FLJ23932 | FLJ38000 | MGC46315 | PDZRN1 | ligand of numb-protein X 2 | - | HPRD | 11922143 |
| MDM2 | HDMX | MGC71221 | hdm2 | Mdm2 p53 binding protein homolog (mouse) | - | HPRD,BioGRID | 12646252 |
| NOTCH1 | TAN1 | hN1 | Notch homolog 1, translocation-associated (Drosophila) | - | HPRD,BioGRID | 8755477 |12682059 |
| RALBP1 | RIP1 | RLIP1 | RLIP76 | ralA binding protein 1 | Affinity Capture-Western | BioGRID | 12775724 |
| SIAH1 | FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1 | seven in absentia homolog 1 (Drosophila) | - | HPRD,BioGRID | 11752454 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NOTCH SIGNALING PATHWAY | 47 | 35 | All SZGR 2.0 genes in this pathway |
| PID NOTCH PATHWAY | 59 | 49 | All SZGR 2.0 genes in this pathway |
| PID MET PATHWAY | 80 | 60 | All SZGR 2.0 genes in this pathway |
| REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | 27 | 18 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY NOTCH1 | 70 | 46 | All SZGR 2.0 genes in this pathway |
| REACTOME AXON GUIDANCE | 251 | 188 | All SZGR 2.0 genes in this pathway |
| REACTOME L1CAM INTERACTIONS | 86 | 62 | All SZGR 2.0 genes in this pathway |
| REACTOME RECYCLING PATHWAY OF L1 | 27 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY NOTCH | 103 | 64 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 COMMON DN | 483 | 336 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN | 382 | 224 | All SZGR 2.0 genes in this pathway |
| RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY DN | 110 | 64 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS UP | 424 | 268 | All SZGR 2.0 genes in this pathway |
| SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN | 36 | 24 | All SZGR 2.0 genes in this pathway |
| JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN | 66 | 47 | All SZGR 2.0 genes in this pathway |
| FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP | 151 | 100 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
| NEMETH INFLAMMATORY RESPONSE LPS DN | 32 | 25 | All SZGR 2.0 genes in this pathway |
| YAGI AML SURVIVAL | 129 | 87 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RESPONSE TO TRABECTEDIN | 50 | 32 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| APRELIKOVA BRCA1 TARGETS | 49 | 33 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS DN | 435 | 289 | All SZGR 2.0 genes in this pathway |
| KYNG NORMAL AGING DN | 30 | 13 | All SZGR 2.0 genes in this pathway |
| KYNG WERNER SYNDROM UP | 20 | 10 | All SZGR 2.0 genes in this pathway |
| GOBERT CORE OLIGODENDROCYTE DIFFERENTIATION | 40 | 28 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |