Gene Page: NOL4

Summary ?
GeneID8715
SymbolNOL4
SynonymsCT125|HRIHFB2255|NOLP
Descriptionnucleolar protein 4
ReferenceMIM:603577|HGNC:HGNC:7870|Ensembl:ENSG00000101746|HPRD:04657|Vega:OTTHUMG00000132291
Gene typeprotein-coding
Map location18q12
Pascal p-value2.661E-5
Sherlock p-value0.559
Fetal beta1.218
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg129114281831804742NOL41.06E-10-0.0114.65E-7DMG:Jaffe_2016
cg210169561831802419NOL42E-8-0.0186.95E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6586487chr118339747NOL487150.1trans
rs17472583chr118340024NOL487150.18trans
rs17432613chr118346091NOL487150.12trans
rs6902183chr6121963786NOL487150.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SIDT10.850.76
RASSF50.840.73
KCNC20.840.74
TRPM20.830.77
PPM1H0.830.75
NDRG40.820.75
OLFM30.810.71
STS0.810.69
CIT0.810.67
GPR1230.810.69
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BCL7C-0.45-0.59
C9orf46-0.42-0.52
FAM36A-0.41-0.45
GTF3C6-0.41-0.49
AC006276.2-0.40-0.45
RPL23A-0.40-0.51
EXOSC8-0.40-0.45
DYNLT1-0.40-0.55
AC135586.1-0.39-0.46
RPLP1-0.39-0.46

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164111All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314188All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER HCP WITH H3K27ME3 9772All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K4ME3 AND H3K27ME3 3834All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K27ME3 5432All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3 13785All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254158All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177132All SZGR 2.0 genes in this pathway