Gene Page: TNFRSF25

Summary
GeneID  8718
Symbol  TNFRSF25
Synonyms  APO-3|DDR3|DR3|LARD|TNFRSF12|TR3|TRAMP|WSL-1|WSL-LR
Description  tumor necrosis factor receptor superfamily, member 25
See related  HGNC:11910|MIM:603366|Ensembl:ENSG00000215788|HPRD:04532|
Locus tag  RP4-650H14.2
Gene type  protein-coding
Map location  1p36.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.362 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NRP20.660.55
AL161668.20.650.58
HEATR20.640.63
ERBB20.640.60
GYS10.630.62
ATP10D0.630.61
PALLD0.630.62
DDR10.630.60
SALL20.630.59
PXN0.620.58
Top 10 negatively co-expressed genes
AF347015.21-0.38-0.45
AF347015.27-0.37-0.42
AF347015.31-0.36-0.42
C5orf53-0.34-0.37
MT-CO2-0.34-0.40
AF347015.8-0.34-0.40
MT-ATP8-0.32-0.41
SYCP3-0.32-0.35
AL139819.3-0.31-0.39
AF347015.33-0.30-0.35
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityNAS9114039 
GO:0005031tumor necrosis factor receptor activityTAS9052839 
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007166cell surface receptor linked signal transductionTAS9052839 
GO:0008624induction of apoptosis by extracellular signalsTAS8994832 
GO:0042981regulation of apoptosisNAS9114039 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolNAS9114039 
GO:0005576extracellular regionIEA-
GO:0005886plasma membraneIDA11911831 
GO:0005887integral to plasma membraneTAS9052839 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAG4BAG-4 | SODDBCL2-associated athanogene 4-HPRD,BioGRID9915703 
DAP3DAP-3 | DKFZp686G12159 | MGC126058 | MGC126059 | MRP-S29 | MRPS29 | bMRP-10death associated protein 3Reconstituted ComplexBioGRID11376335 
NOL3ARC | CARD2 | MYC | MYP | NOP | NOP30nucleolar protein 3 (apoptosis repressor with CARD domain)Phenotypic SuppressionBioGRID9560245 
TNFSF12APO3L | DR3LG | MGC129581 | MGC20669 | TWEAKtumor necrosis factor (ligand) superfamily, member 12-HPRD11094155 
TNFSF15MGC129934 | MGC129935 | TL1 | TL1A | VEGI | VEGI192Atumor necrosis factor (ligand) superfamily, member 15-HPRD,BioGRID11911831 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD,BioGRID8934525 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
BIOCARTA_DEATH_PATHWAY 3324All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN 158102All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN 180101All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN 12686All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN 281186All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_DN 185115All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_UP 162104All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_UP 147101All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN 181107All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
WHITE_NEUROBLASTOMA_WITH_1P36.3_DELETION 2117All SZGR genes in this pathway
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER 8864All SZGR genes in this pathway
OKAWA_NEUROBLASTOMA_1P36_31_DELETION 2219All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_UP 4936All SZGR genes in this pathway
SHIPP_DLBCL_VS_FOLLICULAR_LYMPHOMA_DN 4528All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_DN 3929All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 5034All SZGR genes in this pathway
NATSUME_RESPONSE_TO_INTERFERON_BETA_DN 5233All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
LEE_EARLY_T_LYMPHOCYTE_DN 5736All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED 3721All SZGR genes in this pathway
WOO_LIVER_CANCER_RECURRENCE_UP 10575All SZGR genes in this pathway
ONO_AML1_TARGETS_DN 4125All SZGR genes in this pathway
ONO_FOXP3_TARGETS_DN 4223All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway


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