Gene Page: TNFRSF14
Summary ?
| GeneID | 8764 |
| Symbol | TNFRSF14 |
| Synonyms | ATAR|CD270|HVEA|HVEM|LIGHTR|TR2 |
| Description | tumor necrosis factor receptor superfamily member 14 |
| Reference | MIM:602746|HGNC:HGNC:11912|Ensembl:ENSG00000157873|HPRD:04122|Vega:OTTHUMG00000000792 |
| Gene type | protein-coding |
| Map location | 1p36.32 |
| Pascal p-value | 0.005 |
| Sherlock p-value | 0.494 |
| eGene | Cerebellum Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs9993882 | chr4 | 183824780 | TNFRSF14 | 8764 | 0.09 | trans | ||
| rs10016530 | chr4 | 183824983 | TNFRSF14 | 8764 | 0.09 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NUP85 | 0.95 | 0.94 |
| DAXX | 0.93 | 0.92 |
| VPS16A | 0.93 | 0.93 |
| BAT1 | 0.92 | 0.93 |
| GTF3C5 | 0.92 | 0.92 |
| PRCC | 0.92 | 0.92 |
| TRA2B | 0.92 | 0.93 |
| AP4M1 | 0.91 | 0.91 |
| NOP56 | 0.91 | 0.92 |
| GTF2H4 | 0.91 | 0.92 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.81 | -0.86 |
| MT-CO2 | -0.81 | -0.86 |
| AF347015.27 | -0.80 | -0.86 |
| AF347015.33 | -0.79 | -0.85 |
| MT-CYB | -0.79 | -0.85 |
| AF347015.8 | -0.79 | -0.86 |
| AF347015.15 | -0.76 | -0.84 |
| AF347015.2 | -0.76 | -0.86 |
| AF347015.26 | -0.74 | -0.85 |
| AIFM3 | -0.74 | -0.76 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CHD3 | Mi-2a | Mi2-ALPHA | ZFH | chromodomain helicase DNA binding protein 3 | Two-hybrid | BioGRID | 16169070 |
| GCN1L1 | GCN1 | GCN1L | KIAA0219 | GCN1 general control of amino-acid synthesis 1-like 1 (yeast) | Affinity Capture-MS | BioGRID | 17353931 |
| HDAC4 | HA6116 | HD4 | HDAC-A | HDACA | KIAA0288 | histone deacetylase 4 | - | HPRD | 11463856 |
| LTA | LT | TNFB | TNFSF1 | lymphotoxin alpha (TNF superfamily, member 1) | - | HPRD | 9153189 |
| NRIP1 | FLJ77253 | RIP140 | nuclear receptor interacting protein 1 | - | HPRD | 9774688 |
| P4HB | DSI | ERBA2L | GIT | PDI | PDIA1 | PHDB | PO4DB | PO4HB | PROHB | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide | Affinity Capture-MS | BioGRID | 17353931 |
| PDIA6 | ERP5 | P5 | TXNDC7 | protein disulfide isomerase family A, member 6 | Affinity Capture-MS | BioGRID | 17353931 |
| SEC11A | 1810012E07Rik | SEC11L1 | SPC18 | SPCS4A | sid2895 | SEC11 homolog A (S. cerevisiae) | Affinity Capture-MS | BioGRID | 17353931 |
| TNFSF12-TNFSF13 | TWE-PRIL | TNFSF12-TNFSF13 readthrough transcript | - | HPRD | 10706119 |
| TNFSF13 | APRIL | CD256 | TALL2 | TRDL-1 | UNQ383/PRO715 | ligand | tumor necrosis factor (ligand) superfamily, member 13 | Reconstituted Complex | BioGRID | 10706119 |
| TNFSF14 | CD258 | HVEML | LIGHT | LTg | TR2 | tumor necrosis factor (ligand) superfamily, member 14 | - | HPRD,BioGRID | 11390428 |
| TRAF1 | EBI6 | MGC:10353 | TNF receptor-associated factor 1 | - | HPRD,BioGRID | 9162022 |
| TRAF2 | MGC:45012 | TRAP | TRAP3 | TNF receptor-associated factor 2 | - | HPRD,BioGRID | 9153189 |9162022 |
| TRAF3 | CAP-1 | CD40bp | CRAF1 | LAP1 | TNF receptor-associated factor 3 | - | HPRD,BioGRID | 9162022 |
| TRAF5 | MGC:39780 | RNF84 | TNF receptor-associated factor 5 | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 9153189 |9162022 |
| UGCGL1 | FLJ23671 | FLJ23796 | HUGT1 | UDP-glucose ceramide glucosyltransferase-like 1 | Affinity Capture-MS | BioGRID | 17353931 |
| VIM | FLJ36605 | vimentin | Two-hybrid | BioGRID | 16169070 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | 267 | 161 | All SZGR 2.0 genes in this pathway |
| REACTOME COSTIMULATION BY THE CD28 FAMILY | 63 | 48 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
| BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP | 206 | 111 | All SZGR 2.0 genes in this pathway |
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
| ODONNELL TFRC TARGETS UP | 456 | 228 | All SZGR 2.0 genes in this pathway |
| ODONNELL TARGETS OF MYC AND TFRC UP | 83 | 50 | All SZGR 2.0 genes in this pathway |
| ZEILSTRA CD44 TARGETS UP | 7 | 5 | All SZGR 2.0 genes in this pathway |
| MANALO HYPOXIA UP | 207 | 145 | All SZGR 2.0 genes in this pathway |
| ALCALAY AML BY NPM1 LOCALIZATION DN | 184 | 132 | All SZGR 2.0 genes in this pathway |
| ABE VEGFA TARGETS 2HR | 34 | 21 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 20HR DN | 101 | 70 | All SZGR 2.0 genes in this pathway |
| HELLER HDAC TARGETS SILENCED BY METHYLATION DN | 281 | 179 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
| QI PLASMACYTOMA UP | 259 | 185 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF LCP WITH H3K4ME3 | 128 | 68 | All SZGR 2.0 genes in this pathway |
| ZEMBUTSU SENSITIVITY TO CISPLATIN | 20 | 14 | All SZGR 2.0 genes in this pathway |
| ZEMBUTSU SENSITIVITY TO MITOMYCIN | 19 | 11 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |
| BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE | 151 | 86 | All SZGR 2.0 genes in this pathway |