Gene Page: FADD

Summary ?
GeneID8772
SymbolFADD
SynonymsGIG3|MORT1
DescriptionFas associated via death domain
ReferenceMIM:602457|HGNC:HGNC:3573|Ensembl:ENSG00000168040|HPRD:03909|Vega:OTTHUMG00000167264
Gene typeprotein-coding
Map location11q13.3
Pascal p-value0.342
Fetal beta0.445
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg208210951170049116FADD1.5E-11-0.0162.86E-7DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABCA1ABC-1 | ABC1 | CERP | FLJ14958 | HDLDT1 | MGC164864 | MGC165011 | TGDATP-binding cassette, sub-family A (ABC1), member 1-HPRD,BioGRID12235128 
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alphaCo-purificationBioGRID15659383 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonistCo-purificationBioGRID15659383 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidase-HPRD9045686 |11717445|11717445 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidase-HPRD,BioGRID11717445 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseCASP8 (caspase-8) interacts with FADD.BIND15782135 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD,BioGRID12107169 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD11717445 |12107169|12107169 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidasecaspase-8 interacts with FADD.BIND12220669 
CASP8AP2CED-4 | FLASH | FLJ11208 | KIAA1315 | RIP25caspase 8 associated protein 2-HPRD,BioGRID10235259 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulatorMRIT-beta-1 interacts with FADD. This interaction was modelled on a demonstrated interaction between human MRIT-beta-1 and FADD from an unspecified species.BIND9326610 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulator-HPRD9208847 |11965497 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulatorc-FLIP interacts with FADD.BIND12220669 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulatorAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9208847 |9228018 
|9326610 
DAP3DAP-3 | DKFZp686G12159 | MGC126058 | MGC126059 | MRP-S29 | MRPS29 | bMRP-10death associated protein 3-HPRD,BioGRID11376335 |11753396 
DAPK1DAPK | DKFZp781I035death-associated protein kinase 1-HPRD,BioGRID12911633 
DEDDCASP8IP1 | DEDD1 | DEFT | FLDED1 | KE05death effector domain containing-HPRD,BioGRID9774341 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinCo-purificationBioGRID15659383 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)Fas interacts with FADD.BIND15383280 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)An unspecified isoform of Fas interacts with FADD.BIND15665818 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)-HPRD,BioGRID7538907 |8967952 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)-HPRD7536190 |7538907 
|8967952|7538907 |8967952 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)Affinity Capture-Western
Co-purification		BioGRID12887920 |15659383 
HIPK3DYRK6 | FIST3 | PKY | YAK1homeodomain interacting protein kinase 3Affinity Capture-WesternBioGRID11034606 
IRAK1IRAK | pelleinterleukin-1 receptor-associated kinase 1-HPRD,BioGRID11828002 
LRDDDKFZp434D229 | MGC16925 | PIDDleucine-rich repeats and death domain containing-HPRD,BioGRID10825539 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8Co-purificationBioGRID15659383 
MBD4MED1methyl-CpG binding domain protein 4-HPRD,BioGRID12702765 
MOBKL32C4D | CGI-95 | MGC12264 | MOB1 | MOB3 | PREI3MOB1, Mps One Binder kinase activator-like 3 (yeast)Two-hybridBioGRID16169070 
MSN-moesinCo-purificationBioGRID15659383 
MYD88MYD88Dmyeloid differentiation primary response gene (88)-HPRD,BioGRID11828002 
NACAHSD48 | MGC117224 | NACA1nascent polypeptide-associated complex alpha subunit-HPRD,BioGRID12684039 
NOL3ARC | CARD2 | MYC | MYP | NOP | NOP30nucleolar protein 3 (apoptosis repressor with CARD domain)ARC interacts with FADD.BIND15383280 
NOL3ARC | CARD2 | MYC | MYP | NOP | NOP30nucleolar protein 3 (apoptosis repressor with CARD domain)Phenotypic SuppressionBioGRID9560245 
PEA15HMAT1 | HUMMAT1H | MAT1 | MAT1H | PEA-15 | PEDphosphoprotein enriched in astrocytes 15-HPRD,BioGRID10442631 |10493725 
PRKCZPKC-ZETA | PKC2protein kinase C, zeta-HPRD,BioGRID11739185 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member ACo-purificationBioGRID15659383 
RIPK1FLJ39204 | RIP | RIP1receptor (TNFRSF)-interacting serine-threonine kinase 1Two-hybridBioGRID11854271 
RIPK1FLJ39204 | RIP | RIP1receptor (TNFRSF)-interacting serine-threonine kinase 1-HPRD11002422 
RYBPAAP1 | DEDAF | YEAF1RING1 and YY1 binding proteinAffinity Capture-WesternBioGRID11395500 
SUMO1DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)Two-hybridBioGRID8906799 
TNFRSF10AAPO2 | CD261 | DR4 | MGC9365 | TRAILR-1 | TRAILR1tumor necrosis factor receptor superfamily, member 10a-HPRD,BioGRID9430227 |11376335 
TNFRSF10BCD262 | DR5 | KILLER | KILLER/DR5 | TRAIL-R2 | TRAILR2 | TRICK2 | TRICK2A | TRICK2B | TRICKB | ZTNFR9tumor necrosis factor receptor superfamily, member 10b-HPRD,BioGRID9430227 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1AAffinity Capture-Western
Co-purification		BioGRID8565075 |15659383 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domainTRADD interacts with FADD. This interaction was modeled on a demonstrated interaction between TRADD and FADD, both from an unspecified speciesBIND12796506 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domainAffinity Capture-Western
Two-hybrid		BioGRID8565075 |12911633 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domainFADD interacts with TRADD.BIND11112409 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domainTRADD interacts with FADD.BIND15761471 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD8565075 |10911999 
XPO5FLJ14239 | FLJ32057 | FLJ45606 | KIAA1291exportin 5-HPRD12702765 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG APOPTOSIS 8862All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 10288All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY 7151All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169110All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
BIOCARTA RELA PATHWAY 1612All SZGR 2.0 genes in this pathway
BIOCARTA CERAMIDE PATHWAY 2216All SZGR 2.0 genes in this pathway
BIOCARTA FAS PATHWAY 3022All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY 5843All SZGR 2.0 genes in this pathway
BIOCARTA DEATH PATHWAY 3324All SZGR 2.0 genes in this pathway
BIOCARTA NFKB PATHWAY 2319All SZGR 2.0 genes in this pathway
BIOCARTA SODD PATHWAY 107All SZGR 2.0 genes in this pathway
BIOCARTA TNFR1 PATHWAY 2921All SZGR 2.0 genes in this pathway
ST TUMOR NECROSIS FACTOR PATHWAY 2920All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 6554All SZGR 2.0 genes in this pathway
PID TRAIL PATHWAY 2820All SZGR 2.0 genes in this pathway
PID FAS PATHWAY 3829All SZGR 2.0 genes in this pathway
PID TNF PATHWAY 4633All SZGR 2.0 genes in this pathway
PID CERAMIDE PATHWAY 4837All SZGR 2.0 genes in this pathway
PID HIV NEF PATHWAY 3526All SZGR 2.0 genes in this pathway
REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS 138All SZGR 2.0 genes in this pathway
REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 129All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 7357All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 14894All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418263All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP 5540All SZGR 2.0 genes in this pathway
NADERI BREAST CANCER PROGNOSIS UP 5026All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 11662All SZGR 2.0 genes in this pathway
JAERVINEN AMPLIFIED IN LARYNGEAL CANCER 4024All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214139All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON 15893All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA DN 3929All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN 12386All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C2 1815All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D5 3926All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312203All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN 160101All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271175All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER UP 7353All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 182102All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428246All SZGR 2.0 genes in this pathway