Gene Page: NAPG
Summary ?
| GeneID | 8774 |
| Symbol | NAPG |
| Synonyms | GAMMASNAP |
| Description | NSF attachment protein gamma |
| Reference | MIM:603216|HGNC:HGNC:7642|Ensembl:ENSG00000134265|HPRD:04448|Vega:OTTHUMG00000179119 |
| Gene type | protein-coding |
| Map location | 18p11.22 |
| Pascal p-value | 0.604 |
| Sherlock p-value | 0.957 |
| Fetal beta | -0.419 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans |
| Support | EXOCYTOSIS G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg01442193 | 18 | 10526432 | NAPG | 1.87E-9 | -0.016 | 1.58E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10915848 | chr1 | 225788919 | NAPG | 8774 | 0.13 | trans | ||
| rs9659310 | chr1 | 246014672 | NAPG | 8774 | 0.06 | trans | ||
| rs12997903 | chr2 | 1952083 | NAPG | 8774 | 0.11 | trans | ||
| rs6733654 | chr2 | 1963270 | NAPG | 8774 | 0.01 | trans | ||
| rs2551328 | chr2 | 23984746 | NAPG | 8774 | 0.1 | trans | ||
| rs2551329 | chr2 | 23984991 | NAPG | 8774 | 0.1 | trans | ||
| rs2712089 | chr2 | 24080273 | NAPG | 8774 | 0 | trans | ||
| rs17029291 | chr3 | 32402138 | NAPG | 8774 | 5.629E-4 | trans | ||
| rs16870339 | chr5 | 2705169 | NAPG | 8774 | 0.07 | trans | ||
| rs4617108 | chr7 | 49423831 | NAPG | 8774 | 0.02 | trans | ||
| rs7864672 | chr9 | 31068069 | NAPG | 8774 | 0.1 | trans | ||
| rs4607971 | chr10 | 19407890 | NAPG | 8774 | 0.04 | trans | ||
| rs12873765 | chr13 | 40039651 | NAPG | 8774 | 0.2 | trans | ||
| rs10492735 | chr13 | 40040035 | NAPG | 8774 | 0.2 | trans | ||
| rs1324669 | chr13 | 107872446 | NAPG | 8774 | 0.01 | trans | ||
| rs1761450 | chr19 | 54818034 | NAPG | 8774 | 0.16 | trans | ||
| rs6032293 | chr20 | 44175130 | NAPG | 8774 | 0.08 | trans | ||
| rs9637082 | chr21 | 21213235 | NAPG | 8774 | 0.14 | trans | ||
| rs12157904 | chr22 | 37982011 | NAPG | 8774 | 0.15 | trans | ||
| rs3185480 | 18 | 10487918 | NAPG | ENSG00000134265.8 | 7.506E-7 | 0 | -37984 | gtex_brain_putamen_basal |
| rs1045584 | 18 | 10488091 | NAPG | ENSG00000134265.8 | 6.06E-7 | 0 | -37811 | gtex_brain_putamen_basal |
| rs505893 | 18 | 10488739 | NAPG | ENSG00000134265.8 | 1.842E-6 | 0 | -37163 | gtex_brain_putamen_basal |
| rs593078 | 18 | 10489013 | NAPG | ENSG00000134265.8 | 1.788E-6 | 0 | -36889 | gtex_brain_putamen_basal |
| rs12961978 | 18 | 10489380 | NAPG | ENSG00000134265.8 | 6.989E-7 | 0 | -36522 | gtex_brain_putamen_basal |
| rs653575 | 18 | 10491281 | NAPG | ENSG00000134265.8 | 2.995E-7 | 0 | -34621 | gtex_brain_putamen_basal |
| rs529749 | 18 | 10491304 | NAPG | ENSG00000134265.8 | 3.017E-7 | 0 | -34598 | gtex_brain_putamen_basal |
| rs500222 | 18 | 10491441 | NAPG | ENSG00000134265.8 | 3.125E-7 | 0 | -34461 | gtex_brain_putamen_basal |
| rs397819136 | 18 | 10492051 | NAPG | ENSG00000134265.8 | 5.934E-7 | 0 | -33851 | gtex_brain_putamen_basal |
| rs638170 | 18 | 10492401 | NAPG | ENSG00000134265.8 | 9.621E-8 | 0 | -33501 | gtex_brain_putamen_basal |
| rs577418 | 18 | 10492748 | NAPG | ENSG00000134265.8 | 1.552E-6 | 0 | -33154 | gtex_brain_putamen_basal |
| rs11080425 | 18 | 10493077 | NAPG | ENSG00000134265.8 | 5.64E-7 | 0 | -32825 | gtex_brain_putamen_basal |
| rs2197166 | 18 | 10493908 | NAPG | ENSG00000134265.8 | 5.64E-7 | 0 | -31994 | gtex_brain_putamen_basal |
| rs397858995 | 18 | 10496069 | NAPG | ENSG00000134265.8 | 6.356E-7 | 0 | -29833 | gtex_brain_putamen_basal |
| rs12608388 | 18 | 10496456 | NAPG | ENSG00000134265.8 | 6.323E-7 | 0 | -29446 | gtex_brain_putamen_basal |
| rs16974630 | 18 | 10499123 | NAPG | ENSG00000134265.8 | 6.331E-7 | 0 | -26779 | gtex_brain_putamen_basal |
| rs12953337 | 18 | 10505276 | NAPG | ENSG00000134265.8 | 5.927E-8 | 0 | -20626 | gtex_brain_putamen_basal |
| rs7230144 | 18 | 10505584 | NAPG | ENSG00000134265.8 | 1.106E-6 | 0 | -20318 | gtex_brain_putamen_basal |
| rs148837492 | 18 | 10506086 | NAPG | ENSG00000134265.8 | 2.659E-8 | 0 | -19816 | gtex_brain_putamen_basal |
| rs500029 | 18 | 10506209 | NAPG | ENSG00000134265.8 | 2.858E-7 | 0 | -19693 | gtex_brain_putamen_basal |
| rs8091430 | 18 | 10506375 | NAPG | ENSG00000134265.8 | 5.584E-7 | 0 | -19527 | gtex_brain_putamen_basal |
| rs492820 | 18 | 10507342 | NAPG | ENSG00000134265.8 | 2.159E-6 | 0 | -18560 | gtex_brain_putamen_basal |
| rs201121659 | 18 | 10507963 | NAPG | ENSG00000134265.8 | 1.012E-6 | 0 | -17939 | gtex_brain_putamen_basal |
| rs542735 | 18 | 10507964 | NAPG | ENSG00000134265.8 | 1.008E-6 | 0 | -17938 | gtex_brain_putamen_basal |
| rs8096132 | 18 | 10507965 | NAPG | ENSG00000134265.8 | 8.242E-7 | 0 | -17937 | gtex_brain_putamen_basal |
| rs563331 | 18 | 10512626 | NAPG | ENSG00000134265.8 | 1.544E-6 | 0 | -13276 | gtex_brain_putamen_basal |
| rs71360245 | 18 | 10512959 | NAPG | ENSG00000134265.8 | 1.806E-6 | 0 | -12943 | gtex_brain_putamen_basal |
| rs62093530 | 18 | 10513001 | NAPG | ENSG00000134265.8 | 1.497E-6 | 0 | -12901 | gtex_brain_putamen_basal |
| rs645477 | 18 | 10513242 | NAPG | ENSG00000134265.8 | 1.295E-6 | 0 | -12660 | gtex_brain_putamen_basal |
| rs520666 | 18 | 10515294 | NAPG | ENSG00000134265.8 | 9.364E-8 | 0 | -10608 | gtex_brain_putamen_basal |
| rs522344 | 18 | 10515849 | NAPG | ENSG00000134265.8 | 9.776E-8 | 0 | -10053 | gtex_brain_putamen_basal |
| rs11873815 | 18 | 10517366 | NAPG | ENSG00000134265.8 | 4.447E-8 | 0 | -8536 | gtex_brain_putamen_basal |
| rs473938 | 18 | 10520290 | NAPG | ENSG00000134265.8 | 1.492E-7 | 0 | -5612 | gtex_brain_putamen_basal |
| rs473877 | 18 | 10520309 | NAPG | ENSG00000134265.8 | 3.724E-7 | 0 | -5593 | gtex_brain_putamen_basal |
| rs11663028 | 18 | 10521975 | NAPG | ENSG00000134265.8 | 3.333E-8 | 0 | -3927 | gtex_brain_putamen_basal |
| rs485375 | 18 | 10523143 | NAPG | ENSG00000134265.8 | 7.187E-7 | 0 | -2759 | gtex_brain_putamen_basal |
| rs589573 | 18 | 10523149 | NAPG | ENSG00000134265.8 | 3.778E-7 | 0 | -2753 | gtex_brain_putamen_basal |
| rs588608 | 18 | 10523388 | NAPG | ENSG00000134265.8 | 3.78E-7 | 0 | -2514 | gtex_brain_putamen_basal |
| rs200496690 | 18 | 10523465 | NAPG | ENSG00000134265.8 | 9.754E-8 | 0 | -2437 | gtex_brain_putamen_basal |
| rs482540 | 18 | 10523466 | NAPG | ENSG00000134265.8 | 6.734E-8 | 0 | -2436 | gtex_brain_putamen_basal |
| rs574860 | 18 | 10523467 | NAPG | ENSG00000134265.8 | 6.734E-8 | 0 | -2435 | gtex_brain_putamen_basal |
| rs573168 | 18 | 10523612 | NAPG | ENSG00000134265.8 | 7.192E-7 | 0 | -2290 | gtex_brain_putamen_basal |
| rs578369 | 18 | 10523767 | NAPG | ENSG00000134265.8 | 7.202E-7 | 0 | -2135 | gtex_brain_putamen_basal |
| rs550223 | 18 | 10523811 | NAPG | ENSG00000134265.8 | 7.204E-7 | 0 | -2091 | gtex_brain_putamen_basal |
| rs544553 | 18 | 10524453 | NAPG | ENSG00000134265.8 | 1.223E-7 | 0 | -1449 | gtex_brain_putamen_basal |
| rs649777 | 18 | 10525518 | NAPG | ENSG00000134265.8 | 1.246E-7 | 0 | -384 | gtex_brain_putamen_basal |
| rs512710 | 18 | 10525585 | NAPG | ENSG00000134265.8 | 7.234E-7 | 0 | -317 | gtex_brain_putamen_basal |
| rs2290279 | 18 | 10526187 | NAPG | ENSG00000134265.8 | 5.48E-7 | 0 | 285 | gtex_brain_putamen_basal |
| rs12962879 | 18 | 10526263 | NAPG | ENSG00000134265.8 | 7.502E-7 | 0 | 361 | gtex_brain_putamen_basal |
| rs7241196 | 18 | 10526413 | NAPG | ENSG00000134265.8 | 1.432E-7 | 0 | 511 | gtex_brain_putamen_basal |
| rs12968077 | 18 | 10527354 | NAPG | ENSG00000134265.8 | 3.565E-7 | 0 | 1452 | gtex_brain_putamen_basal |
| rs520218 | 18 | 10527637 | NAPG | ENSG00000134265.8 | 5.393E-9 | 0 | 1735 | gtex_brain_putamen_basal |
| rs693679 | 18 | 10528039 | NAPG | ENSG00000134265.8 | 6.486E-7 | 0 | 2137 | gtex_brain_putamen_basal |
| rs485954 | 18 | 10528414 | NAPG | ENSG00000134265.8 | 6.486E-7 | 0 | 2512 | gtex_brain_putamen_basal |
| rs553754 | 18 | 10529822 | NAPG | ENSG00000134265.8 | 5.393E-9 | 0 | 3920 | gtex_brain_putamen_basal |
| rs509370 | 18 | 10530928 | NAPG | ENSG00000134265.8 | 5.393E-9 | 0 | 5026 | gtex_brain_putamen_basal |
| rs533675 | 18 | 10531606 | NAPG | ENSG00000134265.8 | 4.873E-7 | 0 | 5704 | gtex_brain_putamen_basal |
| rs538188 | 18 | 10532088 | NAPG | ENSG00000134265.8 | 8.612E-7 | 0 | 6186 | gtex_brain_putamen_basal |
| rs652521 | 18 | 10532897 | NAPG | ENSG00000134265.8 | 8.612E-7 | 0 | 6995 | gtex_brain_putamen_basal |
| rs641723 | 18 | 10532939 | NAPG | ENSG00000134265.8 | 4.873E-7 | 0 | 7037 | gtex_brain_putamen_basal |
| rs483995 | 18 | 10533302 | NAPG | ENSG00000134265.8 | 8.612E-7 | 0 | 7400 | gtex_brain_putamen_basal |
| rs397796119 | 18 | 10533797 | NAPG | ENSG00000134265.8 | 4.866E-7 | 0 | 7895 | gtex_brain_putamen_basal |
| rs495484 | 18 | 10535060 | NAPG | ENSG00000134265.8 | 5.867E-7 | 0 | 9158 | gtex_brain_putamen_basal |
| rs518605 | 18 | 10535119 | NAPG | ENSG00000134265.8 | 5.393E-9 | 0 | 9217 | gtex_brain_putamen_basal |
| rs522208 | 18 | 10535490 | NAPG | ENSG00000134265.8 | 4.873E-7 | 0 | 9588 | gtex_brain_putamen_basal |
| rs546966 | 18 | 10535913 | NAPG | ENSG00000134265.8 | 8.612E-7 | 0 | 10011 | gtex_brain_putamen_basal |
| rs550627 | 18 | 10536283 | NAPG | ENSG00000134265.8 | 8.612E-7 | 0 | 10381 | gtex_brain_putamen_basal |
| rs551586 | 18 | 10536628 | NAPG | ENSG00000134265.8 | 4.873E-7 | 0 | 10726 | gtex_brain_putamen_basal |
| rs580216 | 18 | 10536906 | NAPG | ENSG00000134265.8 | 8.612E-7 | 0 | 11004 | gtex_brain_putamen_basal |
| rs499169 | 18 | 10538129 | NAPG | ENSG00000134265.8 | 4.873E-7 | 0 | 12227 | gtex_brain_putamen_basal |
| rs526394 | 18 | 10538758 | NAPG | ENSG00000134265.8 | 1.516E-7 | 0 | 12856 | gtex_brain_putamen_basal |
| rs640832 | 18 | 10539739 | NAPG | ENSG00000134265.8 | 1.83E-6 | 0 | 13837 | gtex_brain_putamen_basal |
| rs510110 | 18 | 10540432 | NAPG | ENSG00000134265.8 | 4.576E-7 | 0 | 14530 | gtex_brain_putamen_basal |
| rs2308032 | 18 | 10540956 | NAPG | ENSG00000134265.8 | 4.428E-8 | 0 | 15054 | gtex_brain_putamen_basal |
| rs540701 | 18 | 10541510 | NAPG | ENSG00000134265.8 | 4.544E-7 | 0 | 15608 | gtex_brain_putamen_basal |
| rs611684 | 18 | 10541681 | NAPG | ENSG00000134265.8 | 3.37E-7 | 0 | 15779 | gtex_brain_putamen_basal |
| rs571229 | 18 | 10542459 | NAPG | ENSG00000134265.8 | 4.194E-7 | 0 | 16557 | gtex_brain_putamen_basal |
| rs571279 | 18 | 10542477 | NAPG | ENSG00000134265.8 | 4.544E-7 | 0 | 16575 | gtex_brain_putamen_basal |
| rs523000 | 18 | 10542501 | NAPG | ENSG00000134265.8 | 4.544E-7 | 0 | 16599 | gtex_brain_putamen_basal |
| rs552180 | 18 | 10543331 | NAPG | ENSG00000134265.8 | 4.544E-7 | 0 | 17429 | gtex_brain_putamen_basal |
| rs643757 | 18 | 10545688 | NAPG | ENSG00000134265.8 | 4.804E-9 | 0 | 19786 | gtex_brain_putamen_basal |
| rs555446 | 18 | 10545918 | NAPG | ENSG00000134265.8 | 2.409E-10 | 0 | 20016 | gtex_brain_putamen_basal |
| rs632245 | 18 | 10545945 | NAPG | ENSG00000134265.8 | 2.931E-8 | 0 | 20043 | gtex_brain_putamen_basal |
| rs616139 | 18 | 10547257 | NAPG | ENSG00000134265.8 | 3.354E-7 | 0 | 21355 | gtex_brain_putamen_basal |
| rs614780 | 18 | 10547559 | NAPG | ENSG00000134265.8 | 5.658E-9 | 0 | 21657 | gtex_brain_putamen_basal |
| rs617040 | 18 | 10549362 | NAPG | ENSG00000134265.8 | 6.898E-9 | 0 | 23460 | gtex_brain_putamen_basal |
| rs547010 | 18 | 10549435 | NAPG | ENSG00000134265.8 | 3.583E-7 | 0 | 23533 | gtex_brain_putamen_basal |
| rs10207 | 18 | 10551782 | NAPG | ENSG00000134265.8 | 3.37E-7 | 0 | 25880 | gtex_brain_putamen_basal |
| rs665604 | 18 | 10553368 | NAPG | ENSG00000134265.8 | 3.37E-7 | 0 | 27466 | gtex_brain_putamen_basal |
| rs653624 | 18 | 10553789 | NAPG | ENSG00000134265.8 | 1.964E-9 | 0 | 27887 | gtex_brain_putamen_basal |
| rs9676242 | 18 | 10554459 | NAPG | ENSG00000134265.8 | 3.476E-8 | 0 | 28557 | gtex_brain_putamen_basal |
| rs484583 | 18 | 10555120 | NAPG | ENSG00000134265.8 | 5.393E-9 | 0 | 29218 | gtex_brain_putamen_basal |
| rs552076 | 18 | 10555135 | NAPG | ENSG00000134265.8 | 6.898E-9 | 0 | 29233 | gtex_brain_putamen_basal |
| rs510558 | 18 | 10555658 | NAPG | ENSG00000134265.8 | 3.37E-7 | 0 | 29756 | gtex_brain_putamen_basal |
| rs518271 | 18 | 10556480 | NAPG | ENSG00000134265.8 | 3.358E-7 | 0 | 30578 | gtex_brain_putamen_basal |
| rs516472 | 18 | 10556672 | NAPG | ENSG00000134265.8 | 3.356E-7 | 0 | 30770 | gtex_brain_putamen_basal |
| rs56658305 | 18 | 10556807 | NAPG | ENSG00000134265.8 | 3.154E-7 | 0 | 30905 | gtex_brain_putamen_basal |
| rs542448 | 18 | 10556836 | NAPG | ENSG00000134265.8 | 1.959E-7 | 0 | 30934 | gtex_brain_putamen_basal |
| rs575325 | 18 | 10564309 | NAPG | ENSG00000134265.8 | 1.5E-8 | 0 | 38407 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LDOC1L | 0.96 | 0.97 |
| ZNF398 | 0.95 | 0.96 |
| DTX4 | 0.95 | 0.96 |
| CAMSAP1 | 0.95 | 0.96 |
| KDM4B | 0.95 | 0.94 |
| SRGAP2 | 0.94 | 0.95 |
| SREBF2 | 0.94 | 0.96 |
| FAM123C | 0.94 | 0.96 |
| ADD2 | 0.94 | 0.96 |
| MTMR4 | 0.94 | 0.95 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SERPINB6 | -0.73 | -0.79 |
| S100B | -0.73 | -0.87 |
| HEPN1 | -0.72 | -0.79 |
| AF347015.31 | -0.72 | -0.89 |
| AIFM3 | -0.72 | -0.78 |
| MT-CO2 | -0.71 | -0.90 |
| FXYD1 | -0.71 | -0.88 |
| HSD17B14 | -0.71 | -0.80 |
| TSC22D4 | -0.71 | -0.79 |
| C5orf53 | -0.71 | -0.77 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PROVENZANI METASTASIS DN | 136 | 94 | All SZGR 2.0 genes in this pathway |
| HU ANGIOGENESIS UP | 21 | 16 | All SZGR 2.0 genes in this pathway |
| HEIDENBLAD AMPLICON 8Q24 DN | 46 | 28 | All SZGR 2.0 genes in this pathway |
| DING LUNG CANCER EXPRESSION BY COPY NUMBER | 100 | 62 | All SZGR 2.0 genes in this pathway |
| GALE APL WITH FLT3 MUTATED DN | 17 | 10 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| LU AGING BRAIN DN | 153 | 120 | All SZGR 2.0 genes in this pathway |
| BAELDE DIABETIC NEPHROPATHY DN | 434 | 302 | All SZGR 2.0 genes in this pathway |
| BLUM RESPONSE TO SALIRASIB UP | 245 | 159 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS UP | 504 | 321 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
| BOUDOUKHA BOUND BY IGF2BP2 | 111 | 59 | All SZGR 2.0 genes in this pathway |