Gene Page: IL18R1
Summary ?
GeneID | 8809 |
Symbol | IL18R1 |
Synonyms | CD218a|CDw218a|IL-1Rrp|IL18RA|IL1RRP |
Description | interleukin 18 receptor 1 |
Reference | MIM:604494|HGNC:HGNC:5988|Ensembl:ENSG00000115604|HPRD:05138|Vega:OTTHUMG00000130780 |
Gene type | protein-coding |
Map location | 2q12 |
Pascal p-value | 0.439 |
eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Association | A combined odds ratio method (Sun et al. 2008), association studies | 1 | Link to SZGene |
GSMA_I | Genome scan meta-analysis | Psr: 0.0004 | |
Expression | Meta-analysis of gene expression | P value: 1.644 | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs1115282 | 2 | 102890970 | IL18R1 | ENSG00000115604.6 | 2.151E-8 | 0 | -81419 | gtex_brain_ba24 |
rs11123917 | 2 | 102891649 | IL18R1 | ENSG00000115604.6 | 2.148E-8 | 0 | -80740 | gtex_brain_ba24 |
rs11683213 | 2 | 102904244 | IL18R1 | ENSG00000115604.6 | 6.004E-9 | 0 | -68145 | gtex_brain_ba24 |
rs13006559 | 2 | 102907630 | IL18R1 | ENSG00000115604.6 | 5.383E-7 | 0 | -64759 | gtex_brain_ba24 |
rs1420091 | 2 | 102917234 | IL18R1 | ENSG00000115604.6 | 1.251E-11 | 0 | -55155 | gtex_brain_ba24 |
rs4399750 | 2 | 102917788 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -54601 | gtex_brain_ba24 |
rs2110660 | 2 | 102918601 | IL18R1 | ENSG00000115604.6 | 2.387E-12 | 0 | -53788 | gtex_brain_ba24 |
rs35727090 | 2 | 102918925 | IL18R1 | ENSG00000115604.6 | 2.359E-11 | 0 | -53464 | gtex_brain_ba24 |
rs200094563 | 2 | 102918931 | IL18R1 | ENSG00000115604.6 | 2.019E-10 | 0 | -53458 | gtex_brain_ba24 |
rs1420090 | 2 | 102919305 | IL18R1 | ENSG00000115604.6 | 1.799E-11 | 0 | -53084 | gtex_brain_ba24 |
rs7565653 | 2 | 102919426 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -52963 | gtex_brain_ba24 |
rs7568913 | 2 | 102920037 | IL18R1 | ENSG00000115604.6 | 2.32E-12 | 0 | -52352 | gtex_brain_ba24 |
rs10179654 | 2 | 102921783 | IL18R1 | ENSG00000115604.6 | 2.257E-12 | 0 | -50606 | gtex_brain_ba24 |
rs4090473 | 2 | 102922987 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -49402 | gtex_brain_ba24 |
rs67627960 | 2 | 102923677 | IL18R1 | ENSG00000115604.6 | 4.757E-10 | 0 | -48712 | gtex_brain_ba24 |
rs11683957 | 2 | 102923821 | IL18R1 | ENSG00000115604.6 | 2.356E-8 | 0 | -48568 | gtex_brain_ba24 |
rs12476925 | 2 | 102924549 | IL18R1 | ENSG00000115604.6 | 2.024E-12 | 0 | -47840 | gtex_brain_ba24 |
rs12476968 | 2 | 102924662 | IL18R1 | ENSG00000115604.6 | 2.032E-12 | 0 | -47727 | gtex_brain_ba24 |
rs6721346 | 2 | 102926320 | IL18R1 | ENSG00000115604.6 | 2.024E-12 | 0 | -46069 | gtex_brain_ba24 |
rs10178436 | 2 | 102926511 | IL18R1 | ENSG00000115604.6 | 2.024E-12 | 0 | -45878 | gtex_brain_ba24 |
rs11679191 | 2 | 102926800 | IL18R1 | ENSG00000115604.6 | 2.038E-12 | 0 | -45589 | gtex_brain_ba24 |
rs11685424 | 2 | 102926981 | IL18R1 | ENSG00000115604.6 | 2.024E-12 | 0 | -45408 | gtex_brain_ba24 |
rs11685480 | 2 | 102927086 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -45303 | gtex_brain_ba24 |
rs6733174 | 2 | 102929012 | IL18R1 | ENSG00000115604.6 | 2.024E-12 | 0 | -43377 | gtex_brain_ba24 |
rs6543118 | 2 | 102929469 | IL18R1 | ENSG00000115604.6 | 2.024E-12 | 0 | -42920 | gtex_brain_ba24 |
rs1558622 | 2 | 102930147 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -42242 | gtex_brain_ba24 |
rs1558621 | 2 | 102930307 | IL18R1 | ENSG00000115604.6 | 2.019E-12 | 0 | -42082 | gtex_brain_ba24 |
rs10189202 | 2 | 102930380 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -42009 | gtex_brain_ba24 |
rs34646353 | 2 | 102930605 | IL18R1 | ENSG00000115604.6 | 3.753E-10 | 0 | -41784 | gtex_brain_ba24 |
rs10191914 | 2 | 102930657 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -41732 | gtex_brain_ba24 |
rs10189711 | 2 | 102930881 | IL18R1 | ENSG00000115604.6 | 2.024E-12 | 0 | -41508 | gtex_brain_ba24 |
rs12712135 | 2 | 102930948 | IL18R1 | ENSG00000115604.6 | 2.024E-12 | 0 | -41441 | gtex_brain_ba24 |
rs1558620 | 2 | 102931395 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -40994 | gtex_brain_ba24 |
rs1558619 | 2 | 102931550 | IL18R1 | ENSG00000115604.6 | 2.024E-12 | 0 | -40839 | gtex_brain_ba24 |
rs12996505 | 2 | 102931802 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -40587 | gtex_brain_ba24 |
rs13020793 | 2 | 102931926 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -40463 | gtex_brain_ba24 |
rs10183388 | 2 | 102932247 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -40142 | gtex_brain_ba24 |
rs953934 | 2 | 102932293 | IL18R1 | ENSG00000115604.6 | 2.501E-11 | 0 | -40096 | gtex_brain_ba24 |
rs1968171 | 2 | 102933552 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -38837 | gtex_brain_ba24 |
rs4613307 | 2 | 102933758 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -38631 | gtex_brain_ba24 |
rs1968170 | 2 | 102933802 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -38587 | gtex_brain_ba24 |
rs11123918 | 2 | 102935237 | IL18R1 | ENSG00000115604.6 | 1.259E-11 | 0 | -37152 | gtex_brain_ba24 |
rs10182639 | 2 | 102935805 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -36584 | gtex_brain_ba24 |
rs11690443 | 2 | 102936131 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -36258 | gtex_brain_ba24 |
rs12712136 | 2 | 102936366 | IL18R1 | ENSG00000115604.6 | 2.485E-10 | 0 | -36023 | gtex_brain_ba24 |
rs974389 | 2 | 102936981 | IL18R1 | ENSG00000115604.6 | 2.501E-11 | 0 | -35408 | gtex_brain_ba24 |
rs4142132 | 2 | 102937482 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -34907 | gtex_brain_ba24 |
rs971764 | 2 | 102938335 | IL18R1 | ENSG00000115604.6 | 2.501E-11 | 0 | -34054 | gtex_brain_ba24 |
rs1420088 | 2 | 102939434 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -32955 | gtex_brain_ba24 |
rs11123920 | 2 | 102939833 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -32556 | gtex_brain_ba24 |
rs6706844 | 2 | 102940412 | IL18R1 | ENSG00000115604.6 | 2.5E-11 | 0 | -31977 | gtex_brain_ba24 |
rs11674832 | 2 | 102940999 | IL18R1 | ENSG00000115604.6 | 2.507E-8 | 0 | -31390 | gtex_brain_ba24 |
rs11675988 | 2 | 102941019 | IL18R1 | ENSG00000115604.6 | 2.718E-8 | 0 | -31370 | gtex_brain_ba24 |
rs11679900 | 2 | 102941074 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -31315 | gtex_brain_ba24 |
rs11676075 | 2 | 102941215 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -31174 | gtex_brain_ba24 |
rs11676124 | 2 | 102941338 | IL18R1 | ENSG00000115604.6 | 8.37E-8 | 0 | -31051 | gtex_brain_ba24 |
rs11123921 | 2 | 102941561 | IL18R1 | ENSG00000115604.6 | 1.315E-11 | 0 | -30828 | gtex_brain_ba24 |
rs112251116 | 2 | 102941818 | IL18R1 | ENSG00000115604.6 | 8.575E-7 | 0 | -30571 | gtex_brain_ba24 |
rs76520363 | 2 | 102945241 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -27148 | gtex_brain_ba24 |
rs76278109 | 2 | 102945378 | IL18R1 | ENSG00000115604.6 | 1.2E-9 | 0 | -27011 | gtex_brain_ba24 |
rs76886731 | 2 | 102945416 | IL18R1 | ENSG00000115604.6 | 6.789E-10 | 0 | -26973 | gtex_brain_ba24 |
rs150341880 | 2 | 102945755 | IL18R1 | ENSG00000115604.6 | 1.469E-11 | 0 | -26634 | gtex_brain_ba24 |
rs138087973 | 2 | 102946082 | IL18R1 | ENSG00000115604.6 | 1.165E-10 | 0 | -26307 | gtex_brain_ba24 |
rs76498201 | 2 | 102946111 | IL18R1 | ENSG00000115604.6 | 3.04E-10 | 0 | -26278 | gtex_brain_ba24 |
rs12996772 | 2 | 102947201 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -25188 | gtex_brain_ba24 |
rs1420102 | 2 | 102948819 | IL18R1 | ENSG00000115604.6 | 2.501E-11 | 0 | -23570 | gtex_brain_ba24 |
rs12466380 | 2 | 102948939 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -23450 | gtex_brain_ba24 |
rs12712140 | 2 | 102951062 | IL18R1 | ENSG00000115604.6 | 1.453E-11 | 0 | -21327 | gtex_brain_ba24 |
rs1997467 | 2 | 102951073 | IL18R1 | ENSG00000115604.6 | 1.317E-11 | 0 | -21316 | gtex_brain_ba24 |
rs1997466 | 2 | 102951467 | IL18R1 | ENSG00000115604.6 | 1.315E-11 | 0 | -20922 | gtex_brain_ba24 |
rs1362350 | 2 | 102951798 | IL18R1 | ENSG00000115604.6 | 1.316E-11 | 0 | -20591 | gtex_brain_ba24 |
rs67058052 | 2 | 102951850 | IL18R1 | ENSG00000115604.6 | 5.11E-12 | 0 | -20539 | gtex_brain_ba24 |
rs397969654 | 2 | 102951851 | IL18R1 | ENSG00000115604.6 | 2.119E-11 | 0 | -20538 | gtex_brain_ba24 |
rs1362349 | 2 | 102951972 | IL18R1 | ENSG00000115604.6 | 1.744E-11 | 0 | -20417 | gtex_brain_ba24 |
rs12712141 | 2 | 102953067 | IL18R1 | ENSG00000115604.6 | 2.21E-11 | 0 | -19322 | gtex_brain_ba24 |
rs59247511 | 2 | 102954190 | IL18R1 | ENSG00000115604.6 | 1.284E-11 | 0 | -18199 | gtex_brain_ba24 |
rs6742875 | 2 | 102987526 | IL18R1 | ENSG00000115604.6 | 1.821E-6 | 0 | 15137 | gtex_brain_ba24 |
rs55664618 | 2 | 103016216 | IL18R1 | ENSG00000115604.6 | 3.195E-11 | 0 | 43827 | gtex_brain_ba24 |
rs11465727 | 2 | 103064503 | IL18R1 | ENSG00000115604.6 | 1.043E-10 | 0 | 92114 | gtex_brain_ba24 |
rs35566453 | 2 | 103064508 | IL18R1 | ENSG00000115604.6 | 9.859E-11 | 0 | 92119 | gtex_brain_ba24 |
rs397873851 | 2 | 103064511 | IL18R1 | ENSG00000115604.6 | 9.843E-11 | 0 | 92122 | gtex_brain_ba24 |
rs11465730 | 2 | 103066858 | IL18R1 | ENSG00000115604.6 | 1.205E-10 | 0 | 94469 | gtex_brain_ba24 |
rs11678721 | 2 | 103073238 | IL18R1 | ENSG00000115604.6 | 3.174E-10 | 0 | 100849 | gtex_brain_ba24 |
rs11677555 | 2 | 103073293 | IL18R1 | ENSG00000115604.6 | 1.205E-10 | 0 | 100904 | gtex_brain_ba24 |
rs6728475 | 2 | 103073950 | IL18R1 | ENSG00000115604.6 | 1.203E-10 | 0 | 101561 | gtex_brain_ba24 |
rs12712150 | 2 | 103074813 | IL18R1 | ENSG00000115604.6 | 1.278E-10 | 0 | 102424 | gtex_brain_ba24 |
rs6705385 | 2 | 103076569 | IL18R1 | ENSG00000115604.6 | 9.017E-10 | 0 | 104180 | gtex_brain_ba24 |
rs6705498 | 2 | 103076670 | IL18R1 | ENSG00000115604.6 | 1.205E-10 | 0 | 104281 | gtex_brain_ba24 |
rs6719196 | 2 | 103076888 | IL18R1 | ENSG00000115604.6 | 1.205E-10 | 0 | 104499 | gtex_brain_ba24 |
rs11676236 | 2 | 103081695 | IL18R1 | ENSG00000115604.6 | 1.205E-10 | 0 | 109306 | gtex_brain_ba24 |
rs11687013 | 2 | 103081721 | IL18R1 | ENSG00000115604.6 | 1.205E-10 | 0 | 109332 | gtex_brain_ba24 |
rs12463588 | 2 | 103085257 | IL18R1 | ENSG00000115604.6 | 9.017E-10 | 0 | 112868 | gtex_brain_ba24 |
rs2310302 | 2 | 103086049 | IL18R1 | ENSG00000115604.6 | 9.017E-10 | 0 | 113660 | gtex_brain_ba24 |
rs12469887 | 2 | 103086758 | IL18R1 | ENSG00000115604.6 | 9.017E-10 | 0 | 114369 | gtex_brain_ba24 |
rs10195075 | 2 | 103087652 | IL18R1 | ENSG00000115604.6 | 1.221E-9 | 0 | 115263 | gtex_brain_ba24 |
rs1403553 | 2 | 103087662 | IL18R1 | ENSG00000115604.6 | 1.221E-9 | 0 | 115273 | gtex_brain_ba24 |
rs4140786 | 2 | 103088176 | IL18R1 | ENSG00000115604.6 | 1.205E-10 | 0 | 115787 | gtex_brain_ba24 |
rs10201184 | 2 | 103089078 | IL18R1 | ENSG00000115604.6 | 9.017E-10 | 0 | 116689 | gtex_brain_ba24 |
rs2015478 | 2 | 103141447 | IL18R1 | ENSG00000115604.6 | 2.046E-6 | 0 | 169058 | gtex_brain_ba24 |
rs1115282 | 2 | 102890970 | IL18R1 | ENSG00000115604.6 | 2.256E-6 | 0 | -81419 | gtex_brain_putamen_basal |
rs11123917 | 2 | 102891649 | IL18R1 | ENSG00000115604.6 | 2.173E-6 | 0 | -80740 | gtex_brain_putamen_basal |
rs11683213 | 2 | 102904244 | IL18R1 | ENSG00000115604.6 | 1.821E-6 | 0 | -68145 | gtex_brain_putamen_basal |
rs1420091 | 2 | 102917234 | IL18R1 | ENSG00000115604.6 | 2.823E-10 | 0 | -55155 | gtex_brain_putamen_basal |
rs4399750 | 2 | 102917788 | IL18R1 | ENSG00000115604.6 | 2.894E-10 | 0 | -54601 | gtex_brain_putamen_basal |
rs2110660 | 2 | 102918601 | IL18R1 | ENSG00000115604.6 | 4.153E-13 | 0 | -53788 | gtex_brain_putamen_basal |
rs35727090 | 2 | 102918925 | IL18R1 | ENSG00000115604.6 | 8.358E-9 | 0 | -53464 | gtex_brain_putamen_basal |
rs200094563 | 2 | 102918931 | IL18R1 | ENSG00000115604.6 | 3.934E-9 | 0 | -53458 | gtex_brain_putamen_basal |
rs1420090 | 2 | 102919305 | IL18R1 | ENSG00000115604.6 | 3.469E-10 | 0 | -53084 | gtex_brain_putamen_basal |
rs7565653 | 2 | 102919426 | IL18R1 | ENSG00000115604.6 | 2.891E-10 | 0 | -52963 | gtex_brain_putamen_basal |
rs7568913 | 2 | 102920037 | IL18R1 | ENSG00000115604.6 | 3.876E-13 | 0 | -52352 | gtex_brain_putamen_basal |
rs10179654 | 2 | 102921783 | IL18R1 | ENSG00000115604.6 | 3.668E-13 | 0 | -50606 | gtex_brain_putamen_basal |
rs4090473 | 2 | 102922987 | IL18R1 | ENSG00000115604.6 | 2.884E-10 | 0 | -49402 | gtex_brain_putamen_basal |
rs67627960 | 2 | 102923677 | IL18R1 | ENSG00000115604.6 | 7.212E-11 | 0 | -48712 | gtex_brain_putamen_basal |
rs12476925 | 2 | 102924549 | IL18R1 | ENSG00000115604.6 | 3.392E-13 | 0 | -47840 | gtex_brain_putamen_basal |
rs12476968 | 2 | 102924662 | IL18R1 | ENSG00000115604.6 | 3.392E-13 | 0 | -47727 | gtex_brain_putamen_basal |
rs6721346 | 2 | 102926320 | IL18R1 | ENSG00000115604.6 | 3.392E-13 | 0 | -46069 | gtex_brain_putamen_basal |
rs10178436 | 2 | 102926511 | IL18R1 | ENSG00000115604.6 | 3.392E-13 | 0 | -45878 | gtex_brain_putamen_basal |
rs11679191 | 2 | 102926800 | IL18R1 | ENSG00000115604.6 | 2.734E-13 | 0 | -45589 | gtex_brain_putamen_basal |
rs11685424 | 2 | 102926981 | IL18R1 | ENSG00000115604.6 | 3.392E-13 | 0 | -45408 | gtex_brain_putamen_basal |
rs11685480 | 2 | 102927086 | IL18R1 | ENSG00000115604.6 | 2.894E-10 | 0 | -45303 | gtex_brain_putamen_basal |
rs6733174 | 2 | 102929012 | IL18R1 | ENSG00000115604.6 | 3.396E-13 | 0 | -43377 | gtex_brain_putamen_basal |
rs6543118 | 2 | 102929469 | IL18R1 | ENSG00000115604.6 | 3.394E-13 | 0 | -42920 | gtex_brain_putamen_basal |
rs1558622 | 2 | 102930147 | IL18R1 | ENSG00000115604.6 | 2.895E-10 | 0 | -42242 | gtex_brain_putamen_basal |
rs1558621 | 2 | 102930307 | IL18R1 | ENSG00000115604.6 | 3.392E-13 | 0 | -42082 | gtex_brain_putamen_basal |
rs10189202 | 2 | 102930380 | IL18R1 | ENSG00000115604.6 | 2.894E-10 | 0 | -42009 | gtex_brain_putamen_basal |
rs34646353 | 2 | 102930605 | IL18R1 | ENSG00000115604.6 | 4.455E-10 | 0 | -41784 | gtex_brain_putamen_basal |
rs10191914 | 2 | 102930657 | IL18R1 | ENSG00000115604.6 | 2.894E-10 | 0 | -41732 | gtex_brain_putamen_basal |
rs10189711 | 2 | 102930881 | IL18R1 | ENSG00000115604.6 | 3.392E-13 | 0 | -41508 | gtex_brain_putamen_basal |
rs12712135 | 2 | 102930948 | IL18R1 | ENSG00000115604.6 | 3.392E-13 | 0 | -41441 | gtex_brain_putamen_basal |
rs1558620 | 2 | 102931395 | IL18R1 | ENSG00000115604.6 | 2.894E-10 | 0 | -40994 | gtex_brain_putamen_basal |
rs1558619 | 2 | 102931550 | IL18R1 | ENSG00000115604.6 | 9.028E-13 | 0 | -40839 | gtex_brain_putamen_basal |
rs12996505 | 2 | 102931802 | IL18R1 | ENSG00000115604.6 | 2.882E-10 | 0 | -40587 | gtex_brain_putamen_basal |
rs13020793 | 2 | 102931926 | IL18R1 | ENSG00000115604.6 | 2.894E-10 | 0 | -40463 | gtex_brain_putamen_basal |
rs10183388 | 2 | 102932247 | IL18R1 | ENSG00000115604.6 | 2.894E-10 | 0 | -40142 | gtex_brain_putamen_basal |
rs953934 | 2 | 102932293 | IL18R1 | ENSG00000115604.6 | 1.813E-11 | 0 | -40096 | gtex_brain_putamen_basal |
rs1968171 | 2 | 102933552 | IL18R1 | ENSG00000115604.6 | 4.118E-10 | 0 | -38837 | gtex_brain_putamen_basal |
rs4613307 | 2 | 102933758 | IL18R1 | ENSG00000115604.6 | 2.264E-10 | 0 | -38631 | gtex_brain_putamen_basal |
rs1968170 | 2 | 102933802 | IL18R1 | ENSG00000115604.6 | 4.501E-10 | 0 | -38587 | gtex_brain_putamen_basal |
rs11123918 | 2 | 102935237 | IL18R1 | ENSG00000115604.6 | 1.408E-9 | 0 | -37152 | gtex_brain_putamen_basal |
rs10182639 | 2 | 102935805 | IL18R1 | ENSG00000115604.6 | 2.303E-9 | 0 | -36584 | gtex_brain_putamen_basal |
rs11690443 | 2 | 102936131 | IL18R1 | ENSG00000115604.6 | 2.661E-9 | 0 | -36258 | gtex_brain_putamen_basal |
rs12712136 | 2 | 102936366 | IL18R1 | ENSG00000115604.6 | 7.663E-9 | 0 | -36023 | gtex_brain_putamen_basal |
rs974389 | 2 | 102936981 | IL18R1 | ENSG00000115604.6 | 2.122E-10 | 0 | -35408 | gtex_brain_putamen_basal |
rs4142132 | 2 | 102937482 | IL18R1 | ENSG00000115604.6 | 4.365E-9 | 0 | -34907 | gtex_brain_putamen_basal |
rs971764 | 2 | 102938335 | IL18R1 | ENSG00000115604.6 | 3.258E-10 | 0 | -34054 | gtex_brain_putamen_basal |
rs1420088 | 2 | 102939434 | IL18R1 | ENSG00000115604.6 | 6.266E-9 | 0 | -32955 | gtex_brain_putamen_basal |
rs11123920 | 2 | 102939833 | IL18R1 | ENSG00000115604.6 | 6.266E-9 | 0 | -32556 | gtex_brain_putamen_basal |
rs6706844 | 2 | 102940412 | IL18R1 | ENSG00000115604.6 | 3.867E-10 | 0 | -31977 | gtex_brain_putamen_basal |
rs11674832 | 2 | 102940999 | IL18R1 | ENSG00000115604.6 | 4.942E-7 | 0 | -31390 | gtex_brain_putamen_basal |
rs11675988 | 2 | 102941019 | IL18R1 | ENSG00000115604.6 | 2.599E-6 | 0 | -31370 | gtex_brain_putamen_basal |
rs11679900 | 2 | 102941074 | IL18R1 | ENSG00000115604.6 | 6.848E-9 | 0 | -31315 | gtex_brain_putamen_basal |
rs11676075 | 2 | 102941215 | IL18R1 | ENSG00000115604.6 | 6.266E-9 | 0 | -31174 | gtex_brain_putamen_basal |
rs11123921 | 2 | 102941561 | IL18R1 | ENSG00000115604.6 | 6.266E-9 | 0 | -30828 | gtex_brain_putamen_basal |
rs112251116 | 2 | 102941818 | IL18R1 | ENSG00000115604.6 | 1.361E-6 | 0 | -30571 | gtex_brain_putamen_basal |
rs76520363 | 2 | 102945241 | IL18R1 | ENSG00000115604.6 | 6.266E-9 | 0 | -27148 | gtex_brain_putamen_basal |
rs76278109 | 2 | 102945378 | IL18R1 | ENSG00000115604.6 | 4.992E-8 | 0 | -27011 | gtex_brain_putamen_basal |
rs76886731 | 2 | 102945416 | IL18R1 | ENSG00000115604.6 | 1.007E-8 | 0 | -26973 | gtex_brain_putamen_basal |
rs150341880 | 2 | 102945755 | IL18R1 | ENSG00000115604.6 | 7.672E-9 | 0 | -26634 | gtex_brain_putamen_basal |
rs138087973 | 2 | 102946082 | IL18R1 | ENSG00000115604.6 | 1.061E-8 | 0 | -26307 | gtex_brain_putamen_basal |
rs76498201 | 2 | 102946111 | IL18R1 | ENSG00000115604.6 | 8.768E-9 | 0 | -26278 | gtex_brain_putamen_basal |
rs12996772 | 2 | 102947201 | IL18R1 | ENSG00000115604.6 | 6.266E-9 | 0 | -25188 | gtex_brain_putamen_basal |
rs1420102 | 2 | 102948819 | IL18R1 | ENSG00000115604.6 | 5.107E-10 | 0 | -23570 | gtex_brain_putamen_basal |
rs12466380 | 2 | 102948939 | IL18R1 | ENSG00000115604.6 | 6.266E-9 | 0 | -23450 | gtex_brain_putamen_basal |
rs12712140 | 2 | 102951062 | IL18R1 | ENSG00000115604.6 | 6.871E-9 | 0 | -21327 | gtex_brain_putamen_basal |
rs1997467 | 2 | 102951073 | IL18R1 | ENSG00000115604.6 | 6.266E-9 | 0 | -21316 | gtex_brain_putamen_basal |
rs1997466 | 2 | 102951467 | IL18R1 | ENSG00000115604.6 | 6.267E-9 | 0 | -20922 | gtex_brain_putamen_basal |
rs1362350 | 2 | 102951798 | IL18R1 | ENSG00000115604.6 | 6.278E-9 | 0 | -20591 | gtex_brain_putamen_basal |
rs67058052 | 2 | 102951850 | IL18R1 | ENSG00000115604.6 | 5.919E-9 | 0 | -20539 | gtex_brain_putamen_basal |
rs397969654 | 2 | 102951851 | IL18R1 | ENSG00000115604.6 | 6.099E-9 | 0 | -20538 | gtex_brain_putamen_basal |
rs1362349 | 2 | 102951972 | IL18R1 | ENSG00000115604.6 | 7.777E-9 | 0 | -20417 | gtex_brain_putamen_basal |
rs12712141 | 2 | 102953067 | IL18R1 | ENSG00000115604.6 | 6.266E-9 | 0 | -19322 | gtex_brain_putamen_basal |
rs59247511 | 2 | 102954190 | IL18R1 | ENSG00000115604.6 | 5.322E-9 | 0 | -18199 | gtex_brain_putamen_basal |
rs55664618 | 2 | 103016216 | IL18R1 | ENSG00000115604.6 | 1.036E-6 | 0 | 43827 | gtex_brain_putamen_basal |
rs11465727 | 2 | 103064503 | IL18R1 | ENSG00000115604.6 | 1.253E-6 | 0 | 92114 | gtex_brain_putamen_basal |
rs35566453 | 2 | 103064508 | IL18R1 | ENSG00000115604.6 | 2.577E-6 | 0 | 92119 | gtex_brain_putamen_basal |
rs397873851 | 2 | 103064511 | IL18R1 | ENSG00000115604.6 | 3.009E-6 | 0 | 92122 | gtex_brain_putamen_basal |
rs11465730 | 2 | 103066858 | IL18R1 | ENSG00000115604.6 | 1.812E-6 | 0 | 94469 | gtex_brain_putamen_basal |
rs11678721 | 2 | 103073238 | IL18R1 | ENSG00000115604.6 | 2.815E-6 | 0 | 100849 | gtex_brain_putamen_basal |
rs11677555 | 2 | 103073293 | IL18R1 | ENSG00000115604.6 | 1.812E-6 | 0 | 100904 | gtex_brain_putamen_basal |
rs6728475 | 2 | 103073950 | IL18R1 | ENSG00000115604.6 | 1.812E-6 | 0 | 101561 | gtex_brain_putamen_basal |
rs12712150 | 2 | 103074813 | IL18R1 | ENSG00000115604.6 | 1.835E-6 | 0 | 102424 | gtex_brain_putamen_basal |
rs6705385 | 2 | 103076569 | IL18R1 | ENSG00000115604.6 | 3.412E-6 | 0 | 104180 | gtex_brain_putamen_basal |
rs6705498 | 2 | 103076670 | IL18R1 | ENSG00000115604.6 | 1.812E-6 | 0 | 104281 | gtex_brain_putamen_basal |
rs6719196 | 2 | 103076888 | IL18R1 | ENSG00000115604.6 | 1.812E-6 | 0 | 104499 | gtex_brain_putamen_basal |
rs11676236 | 2 | 103081695 | IL18R1 | ENSG00000115604.6 | 1.812E-6 | 0 | 109306 | gtex_brain_putamen_basal |
rs11687013 | 2 | 103081721 | IL18R1 | ENSG00000115604.6 | 1.812E-6 | 0 | 109332 | gtex_brain_putamen_basal |
rs12463588 | 2 | 103085257 | IL18R1 | ENSG00000115604.6 | 3.412E-6 | 0 | 112868 | gtex_brain_putamen_basal |
rs2310302 | 2 | 103086049 | IL18R1 | ENSG00000115604.6 | 3.412E-6 | 0 | 113660 | gtex_brain_putamen_basal |
rs12469887 | 2 | 103086758 | IL18R1 | ENSG00000115604.6 | 3.412E-6 | 0 | 114369 | gtex_brain_putamen_basal |
rs10195075 | 2 | 103087652 | IL18R1 | ENSG00000115604.6 | 3.087E-6 | 0 | 115263 | gtex_brain_putamen_basal |
rs1403553 | 2 | 103087662 | IL18R1 | ENSG00000115604.6 | 3.087E-6 | 0 | 115273 | gtex_brain_putamen_basal |
rs4140786 | 2 | 103088176 | IL18R1 | ENSG00000115604.6 | 1.812E-6 | 0 | 115787 | gtex_brain_putamen_basal |
rs10201184 | 2 | 103089078 | IL18R1 | ENSG00000115604.6 | 3.412E-6 | 0 | 116689 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
CDC2L5 | 0.94 | 0.96 |
CHD8 | 0.94 | 0.97 |
ANKLE2 | 0.93 | 0.94 |
KIAA1967 | 0.93 | 0.94 |
SART3 | 0.93 | 0.96 |
SFRS14 | 0.93 | 0.93 |
NFX1 | 0.93 | 0.94 |
ZKSCAN5 | 0.93 | 0.94 |
GON4L | 0.93 | 0.95 |
ZNF407 | 0.93 | 0.95 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.31 | -0.84 | -0.90 |
MT-CO2 | -0.84 | -0.89 |
FXYD1 | -0.82 | -0.87 |
AF347015.33 | -0.81 | -0.85 |
AF347015.27 | -0.80 | -0.86 |
AF347015.21 | -0.80 | -0.92 |
IFI27 | -0.80 | -0.86 |
AF347015.8 | -0.80 | -0.88 |
HIGD1B | -0.79 | -0.88 |
MT-CYB | -0.79 | -0.85 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0004888 | transmembrane receptor activity | IEA | - | |
GO:0004872 | receptor activity | IEA | - | |
GO:0004908 | interleukin-1 receptor activity | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0007165 | signal transduction | TAS | 9325300 | |
GO:0045087 | innate immune response | IEA | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0016021 | integral to membrane | IEA | - | |
GO:0005886 | plasma membrane | TAS | 9325300 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | 267 | 161 | All SZGR 2.0 genes in this pathway |
BIOCARTA IL12 PATHWAY | 23 | 17 | All SZGR 2.0 genes in this pathway |
BIOCARTA NKT PATHWAY | 29 | 21 | All SZGR 2.0 genes in this pathway |
BIOCARTA TH1TH2 PATHWAY | 19 | 14 | All SZGR 2.0 genes in this pathway |
PID IL12 2PATHWAY | 63 | 54 | All SZGR 2.0 genes in this pathway |
PID IL23 PATHWAY | 37 | 30 | All SZGR 2.0 genes in this pathway |
PID IL12 STAT4 PATHWAY | 33 | 29 | All SZGR 2.0 genes in this pathway |
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN | 320 | 184 | All SZGR 2.0 genes in this pathway |
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN | 95 | 57 | All SZGR 2.0 genes in this pathway |
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP | 66 | 47 | All SZGR 2.0 genes in this pathway |
LUCAS HNF4A TARGETS UP | 58 | 36 | All SZGR 2.0 genes in this pathway |
RASHI RESPONSE TO IONIZING RADIATION 6 | 84 | 54 | All SZGR 2.0 genes in this pathway |
WEINMANN ADAPTATION TO HYPOXIA DN | 41 | 33 | All SZGR 2.0 genes in this pathway |
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
HOFMANN CELL LYMPHOMA DN | 39 | 29 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 48HR UP | 180 | 125 | All SZGR 2.0 genes in this pathway |
JAZAERI BREAST CANCER BRCA1 VS BRCA2 UP | 49 | 28 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
GAVIN FOXP3 TARGETS CLUSTER P3 | 160 | 103 | All SZGR 2.0 genes in this pathway |
KYNG DNA DAMAGE BY 4NQO OR UV | 63 | 44 | All SZGR 2.0 genes in this pathway |
KYNG DNA DAMAGE UP | 226 | 164 | All SZGR 2.0 genes in this pathway |
SMID BREAST CANCER NORMAL LIKE UP | 476 | 285 | All SZGR 2.0 genes in this pathway |
GAURNIER PSMD4 TARGETS | 73 | 55 | All SZGR 2.0 genes in this pathway |
BOQUEST STEM CELL DN | 216 | 143 | All SZGR 2.0 genes in this pathway |
BOYLAN MULTIPLE MYELOMA C D DN | 252 | 155 | All SZGR 2.0 genes in this pathway |
GOLDRATH ANTIGEN RESPONSE | 346 | 192 | All SZGR 2.0 genes in this pathway |
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP | 107 | 67 | All SZGR 2.0 genes in this pathway |
HAN SATB1 TARGETS DN | 442 | 275 | All SZGR 2.0 genes in this pathway |
POOLA INVASIVE BREAST CANCER UP | 288 | 168 | All SZGR 2.0 genes in this pathway |
BOYLAN MULTIPLE MYELOMA PCA1 UP | 101 | 66 | All SZGR 2.0 genes in this pathway |
WONG ADULT TISSUE STEM MODULE | 721 | 492 | All SZGR 2.0 genes in this pathway |
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5 | 30 | 22 | All SZGR 2.0 genes in this pathway |
LI INDUCED T TO NATURAL KILLER UP | 307 | 182 | All SZGR 2.0 genes in this pathway |
WIERENGA STAT5A TARGETS UP | 217 | 131 | All SZGR 2.0 genes in this pathway |
PURBEY TARGETS OF CTBP1 NOT SATB1 UP | 344 | 215 | All SZGR 2.0 genes in this pathway |