Gene Page: GALR2

Summary ?
GeneID8811
SymbolGALR2
SynonymsGAL2-R|GALNR2|GALR-2
Descriptiongalanin receptor 2
ReferenceMIM:603691|HGNC:HGNC:4133|Ensembl:ENSG00000182687|HPRD:04735|Vega:OTTHUMG00000167479
Gene typeprotein-coding
Map location17q25.3
Pascal p-value0.477
Fetal beta0.048
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs997135chr2012330295GALR288110.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
WDR740.920.92
ILKAP0.920.92
RPAIN0.920.91
MAF10.920.91
EIF60.910.92
USF10.910.91
BCS1L0.900.90
PPP4C0.900.91
NGDN0.900.90
WDR460.900.90
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.76-0.84
AF347015.33-0.74-0.83
AF347015.8-0.73-0.82
MT-CO2-0.73-0.80
AF347015.15-0.73-0.84
AF347015.31-0.72-0.80
MT-CYB-0.72-0.81
AF347015.2-0.71-0.84
AF347015.26-0.70-0.83
AF347015.9-0.67-0.80

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004966galanin receptor activityTAS9480833 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)9832121 
GO:0031175neurite developmentIEAneuron, axon, neurite, dendrite (GO term level: 10)-
GO:0007204elevation of cytosolic calcium ion concentrationTAS9685625 
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messengerTAS9685625 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007631feeding behaviorTAS9480833 
GO:0007611learning or memoryTAS9480833 
GO:0007586digestionTAS9832121 
GO:0006936muscle contractionTAS9480833 
GO:0007275multicellular organismal developmentTAS9480833 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneTAS9480833 
GO:0005886plasma membraneTAS9480833 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195114All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355243All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS 205145All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 UP 11866All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 14985All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME2 AND H3K27ME3 5935All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 4 1511All SZGR 2.0 genes in this pathway
QI HYPOXIA 14096All SZGR 2.0 genes in this pathway