Gene Page

Home
Datasets
Search
Analysis & Tools
Documents
About SZGR
Quick search: (e.g. 207 or AKT)

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

Release Site Map Support Contact us

Gene Page: SYNGAP1

Summary

GeneID

8831

Symbol

SYNGAP1

Synonyms

DKFZp761G1421|KIAA1938|RASA1|RASA5|SYNGAP

Description

synaptic Ras GTPase activating protein 1 homolog (rat)

Locus tag

DASS-97D12.6

Gene type

protein-coding

Map location

6p21.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.033

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

GATM

0.83

0.80

RFTN2

0.81

GPM6B

0.79

ANXA5

0.79

0.77

IRF2

0.79

TOR1AIP1

0.78

0.77

SLC9A9

0.77

SDC2

0.76

0.74

SNX5

0.76

0.77

ADD3

0.76

0.77

Top 10 negatively co-expressed genes

NEUROD2

-0.41

-0.28

TMEM108

-0.41

-0.25

BACH2

-0.41

-0.19

DACT1

-0.41

-0.20

SCUBE1

-0.40

-0.36

ISLR2

-0.40

-0.21

DAB1

-0.40

-0.17

NAV2

-0.39

-0.21

SH2D2A

-0.39

-0.42

TP53I11

-0.39

-0.25

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005096

GTPase activator activity

IEA

GO:0017124

SH3 domain binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007165

signal transduction

IEA

GO:0051056

regulation of small GTPase mediated signal transduction

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005622

intracellular

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CAMK2A	CAMKA \| KIAA0968	calcium/calmodulin-dependent protein kinase II alpha	-	HPRD	11278737 \|12951199
DLG3	KIAA1232 \| MRX \| MRX90 \| NE-Dlg \| NEDLG \| SAP102	discs, large homolog 3 (neuroendocrine-dlg, Drosophila)	-	HPRD,BioGRID	9581761
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	Two-hybrid	BioGRID	9581761
DLGAP4	DAP4 \| KIAA0964 \| MGC131862 \| RP5-977B1.6 \| SAPAP4	discs, large (Drosophila) homolog-associated protein 4	-	HPRD	9581761 \|9620694 \|11487731
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
GRIN2B	MGC142178 \| MGC142180 \| NMDAR2B \| NR2B \| hNR3	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	-	HPRD	9620694
GRIN2D	EB11 \| NMDAR2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	-	HPRD	10862698
ULK1	ATG1 \| FLJ38455 \| UNC51 \| Unc51.1	unc-51-like kinase 1 (C. elegans)	-	HPRD,BioGRID	15014045
ULK2	KIAA0623 \| Unc51.2	unc-51-like kinase 2 (C. elegans)	-	HPRD,BioGRID	15014045

Pathway annotation

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	1483	1490	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-135	919	925	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	919	925	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-144	1484	1490	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-185	929	935	m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-210	543	550	1A,m8	hsa-miR-210	CUGUGCGUGUGACAGCGGCUGA
miR-219	417	423	m8	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-23	1378	1384	1A	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	1378	1384	1A	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-29	288	294	1A	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-326	702	708	m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-328	1344	1350	1A	hsa-miR-328^brain	CUGGCCCUCUCUGCCCUUCCGU
miR-339	1014	1020	m8	hsa-miR-339	UCCCUGUCCUCCAGGAGCUCA
miR-384	912	919	1A,m8	hsa-miR-384	AUUCCUAGAAAUUGUUCAUA
miR-409-5p	405	411	1A	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-410	1359	1365	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-488	1471	1477	m8	hsa-miR-488	CCCAGAUAAUGGCACUCUCAA
miR-491	587	593	m8	hsa-miR-491^brain	AGUGGGGAACCCUUCCAUGAGGA
miR-539	513	520	1A,m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.