SZGR2

Summary ?

GeneID	887
Symbol	CCKBR
Synonyms	CCK-B\|CCK2R\|GASR
Description	cholecystokinin B receptor
Reference	MIM:118445\|HGNC:HGNC:1571\|Ensembl:ENSG00000110148\|HPRD:00323\|Vega:OTTHUMG00000133380
Gene type	protein-coding
Map location	11p15.4
Pascal p-value	0.55
Sherlock p-value	0.931
Fetal beta	-0.96
eGene	Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
UBA3	0.91	0.88
POLR3F	0.90	0.87
MRPS35	0.90	0.86
ORC4L	0.88	0.87
DCK	0.88	0.86
PMPCB	0.87	0.84
C11orf46	0.87	0.84
ATG5	0.87	0.84
FAM49B	0.86	0.83
RG9MTD1	0.86	0.85

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.26	-0.67	-0.62
AF347015.2	-0.65	-0.59
MT-CO2	-0.65	-0.57
AF347015.8	-0.65	-0.59
MT-CYB	-0.64	-0.58
AF347015.15	-0.63	-0.58
AF347015.18	-0.62	-0.62
AF347015.33	-0.62	-0.57
AF347015.31	-0.60	-0.54
GPT	-0.59	-0.60

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004872	receptor activity	IEA		-
GO:0004435	phosphoinositide phospholipase C activity	TAS		7681836
GO:0015054	gastrin receptor activity	IEA		-
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	TAS		10400698
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007202	activation of phospholipase C activity	TAS		7681836
GO:0007204	elevation of cytosolic calcium ion concentration	TAS		7681836
GO:0008284	positive regulation of cell proliferation	TAS		8349705
GO:0007631	feeding behavior	TAS		7681836
GO:0007600	sensory perception	TAS		7681836
GO:0007586	digestion	TAS		7681836
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005886	plasma membrane	TAS		7681836
GO:0005887	integral to plasma membrane	TAS		7681836

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CALCIUM SIGNALING PATHWAY	178	134	All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION	272	195	All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	205	136	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS	188	108	All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	305	177	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS	184	116	All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING	805	368	All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING	408	246	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN	186	107	All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR	62	33	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM5	94	59	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER UP	49	36	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN	153	120	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K27ME3	79	59	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3	435	318	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP	143	100	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3	341	243	All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3	590	403	All SZGR 2.0 genes in this pathway
GUILLAUMOND KLF10 TARGETS UP	51	39	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-148/152	423	429	1A	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
				hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-30-3p	479	486	1A,m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
				hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
				hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
				hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CCKBR