Summary ?
GeneID8907
SymbolAP1M1
SynonymsAP47|CLAPM2|CLTNM|MU-1A
Descriptionadaptor related protein complex 1 mu 1 subunit
ReferenceMIM:603535|HGNC:HGNC:13667|Ensembl:ENSG00000072958|HPRD:04639|Vega:OTTHUMG00000182323
Gene typeprotein-coding
Map location19p13.12
Pascal p-value0.045
Sherlock p-value0.537
eGeneCerebellar Hemisphere
Cerebellum
Nucleus accumbens basal ganglia
Myers' cis & trans
Meta
SupportENDOCYTOSIS

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7554118chr134347105AP1M189070.14trans
rs9851591chr340042036AP1M189070.15trans
rs6791790chr340050274AP1M189070.15trans
rs4302323chr340052101AP1M189070.15trans
rs17093091chr1423954891AP1M189070.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TNRC6A0.610.61
NBPF120.610.55
MACF10.600.60
PROM20.590.55
MLL30.590.59
CNKSR10.590.53
MLL0.590.56
POLE0.590.57
CHD20.590.60
UBR40.590.53
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
IFI27-0.39-0.45
MGST2-0.38-0.44
B2M-0.38-0.43
MYL3-0.38-0.45
MT-CO2-0.37-0.44
AF347015.31-0.37-0.44
HIGD1B-0.37-0.45
ACOT13-0.37-0.39
S100B-0.37-0.43
VAMP5-0.36-0.46

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP1G1ADTG | CLAPG1 | MGC18255adaptor-related protein complex 1, gamma 1 subunitAffinity Capture-WesternBioGRID10535737 
AP1M2AP1-mu2 | HSMU1B | MU-1B | MU1B | mu2adaptor-related protein complex 1, mu 2 subunit-HPRD10535737 |11157985 
AP2B1ADTB2 | AP105B | AP2-BETA | CLAPB1 | DKFZp781K0743adaptor-related protein complex 2, beta 1 subunitTwo-hybridBioGRID16189514 
CTLA4CD152 | CELIAC3 | CTLA-4 | GSE | IDDM12cytotoxic T-lymphocyte-associated protein 4-HPRD,BioGRID9812899 |11583591 
DCXDBCN | DC | LISX | SCLH | XLISdoublecortin-HPRD11591131 
DVL2-dishevelled, dsh homolog 2 (Drosophila)Two-hybridBioGRID16189514 
EHD2FLJ96617 | PAST2EH-domain containing 2-HPRD15182197 
FXR2FMR1L2fragile X mental retardation, autosomal homolog 2Two-hybridBioGRID16189514 
HNRNPCC1 | C2 | HNRNP | HNRPC | MGC104306 | MGC105117 | MGC117353 | MGC131677 | SNRPCheterogeneous nuclear ribonucleoprotein C (C1/C2)Two-hybridBioGRID16189514 
KIF13AFLJ27232 | bA500C11.2kinesin family member 13A-HPRD,BioGRID11106728 
LAMP1CD107a | LAMPA | LGP120lysosomal-associated membrane protein 1-HPRD,BioGRID7569928 
LDOC1BCUR1 | Mar7 | Mart7leucine zipper, down-regulated in cancer 1Two-hybridBioGRID16189514 
MTF1MGC23036 | MTF-1 | ZRFmetal-regulatory transcription factor 1Two-hybridBioGRID16189514 
RUNDC3ARAP2IP | RPIP8RUN domain containing 3ATwo-hybridBioGRID16189514 
SELPCD62 | CD62P | FLJ45155 | GMP140 | GRMP | LECAM3 | PADGEM | PSELselectin P (granule membrane protein 140kDa, antigen CD62)Co-crystal StructureBioGRID11247301 
TGOLN2MGC14722 | TGN38 | TGN46 | TGN48 | TGN51 | TTGN2trans-golgi network protein 2-HPRD,BioGRID7569928 
TIFAMGC20791 | T2BP | T6BP | TIFAATRAF-interacting protein with forkhead-associated domainTwo-hybridBioGRID16189514 
VAMP4VAMP24vesicle-associated membrane protein 4-HPRD,BioGRID11598115 |14608369 
ZBTB8BOZF1 | FLJ90065 | MGC17919zinc finger and BTB domain containing 8Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG LYSOSOME 12183All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY 3933All SZGR 2.0 genes in this pathway
REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION 105All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING 12974All SZGR 2.0 genes in this pathway
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS 2112All SZGR 2.0 genes in this pathway
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 6031All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION 9161All SZGR 2.0 genes in this pathway
REACTOME LYSOSOME VESICLE BIOGENESIS 2311All SZGR 2.0 genes in this pathway
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 5327All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 13281All SZGR 2.0 genes in this pathway
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 2819All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 1 4527All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS UP 9356All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194133All SZGR 2.0 genes in this pathway