Gene Page: CCND2

Summary ?
GeneID894
SymbolCCND2
SynonymsKIAK0002|MPPH3
Descriptioncyclin D2
ReferenceMIM:123833|HGNC:HGNC:1583|Ensembl:ENSG00000118971|HPRD:00451|Vega:OTTHUMG00000168123
Gene typeprotein-coding
Map location12p13
Pascal p-value0.071
Sherlock p-value0.05
Fetal beta0.734
DMG2 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg11135021124382112CCND25.262E-4-0.460.048DMG:Wockner_2014
cg10689512124381019CCND26.93E-8-0.0261.68E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RBM15B0.930.93
ZNF710.930.94
EPHB20.930.93
NUP620.920.93
ZNF480.920.94
CCDC970.920.90
AKT10.920.90
DNMT10.920.93
PFAS0.920.93
CABLES20.920.95
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.74-0.89
AF347015.27-0.73-0.88
MT-CO2-0.72-0.88
AF347015.33-0.71-0.85
MT-CYB-0.70-0.86
AF347015.8-0.70-0.88
C5orf53-0.69-0.74
S100B-0.69-0.81
FXYD1-0.68-0.83
HLA-F-0.68-0.73

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKAP8AKAP95 | DKFZp586B1222A kinase (PRKA) anchor protein 8-HPRD,BioGRID14641107 
BCL6BCL5 | BCL6A | LAZ3 | ZBTB27 | ZNF51B-cell CLL/lymphoma 6BCL6 interacts with the CCND2 promoter region.BIND15531890 
CDK4CMM3 | MGC14458 | PSK-J3cyclin-dependent kinase 4CCND2 interacts with CDK4BIND11291051 
CDK4CMM3 | MGC14458 | PSK-J3cyclin-dependent kinase 4-HPRD,BioGRID11358847 
CDK5PSSALREcyclin-dependent kinase 5-HPRD,BioGRID9422379 
CDK6MGC59692 | PLSTIRE | STQTL11cyclin-dependent kinase 6-HPRD,BioGRID11358847 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)Two-hybridBioGRID16189514 
CDKN1BCDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1cyclin-dependent kinase inhibitor 1B (p27, Kip1)Two-hybridBioGRID16189514 
CDKN2AARF | CDK4I | CDKN2 | CMM2 | INK4 | INK4a | MLM | MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)Reconstituted ComplexBioGRID15065884 
DMTF1DMP1 | DMTF | FLJ41265 | hDMP1cyclin D binding myb-like transcription factor 1-HPRD8887674 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1NcoR interacts with the CCND2 promoter region.BIND15531890 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2SMRT interacts with the CCND2 promoter region.BIND15531890 
NPDC1CAB | CAB- | CAB-1 | CAB1 | DKFZp586J0523neural proliferation, differentiation and control, 1-HPRD,BioGRID11042687 
RBX1BA554C12.1 | MGC13357 | MGC1481 | RNF75 | ROC1ring-box 1Affinity Capture-WesternBioGRID11311237 
SERTAD1SEI1 | TRIP-Br1SERTA domain containing 1-HPRD,BioGRID15065884 
STAT5AMGF | STAT5signal transducer and activator of transcription 5ASTAT5A interacts with Cyclin D2 promoter.BIND15735688 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Affinity Capture-WesternBioGRID16357142 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CELL CYCLE 12884All SZGR 2.0 genes in this pathway
KEGG P53 SIGNALING PATHWAY 6945All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY 151112All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155105All SZGR 2.0 genes in this pathway
BIOCARTA CELLCYCLE PATHWAY 2315All SZGR 2.0 genes in this pathway
WNT SIGNALING 8971All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY 7962All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY 8060All SZGR 2.0 genes in this pathway
PID IL2 STAT5 PATHWAY 3023All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 6546All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE 3823All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 13779All SZGR 2.0 genes in this pathway
KORKOLA EMBRYONAL CARCINOMA UP 4127All SZGR 2.0 genes in this pathway
KORKOLA TERATOMA UP 1611All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR UP 2014All SZGR 2.0 genes in this pathway
KORKOLA SEMINOMA UP 4427All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481290All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351230All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391222All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255177All SZGR 2.0 genes in this pathway
TIMOFEEVA GROWTH STRESS VIA STAT1 DN 1612All SZGR 2.0 genes in this pathway
RODRIGUES DCC TARGETS DN 12184All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204140All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP 457269All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238144All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP 11466All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501327All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805505All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP 177113All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 13694All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
CAIRO PML TARGETS BOUND BY MYC UP 2317All SZGR 2.0 genes in this pathway
BARIS THYROID CANCER DN 5945All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS UP 3320All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP 5844All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK DN 13797All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP 197135All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB UP 2920All SZGR 2.0 genes in this pathway
BAKER HEMATOPOIESIS STAT3 TARGETS 1612All SZGR 2.0 genes in this pathway
BAKER HEMATOPOESIS STAT5 TARGETS 77All SZGR 2.0 genes in this pathway
SUZUKI AMPLIFIED IN ORAL CANCER 1612All SZGR 2.0 genes in this pathway
MATTIOLI MULTIPLE MYELOMA WITH 14Q32 TRANSLOCATIONS 3625All SZGR 2.0 genes in this pathway
FUNG IL2 SIGNALING 1 117All SZGR 2.0 genes in this pathway
FUNG IL2 TARGETS WITH STAT5 BINDING SITES 75All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176111All SZGR 2.0 genes in this pathway
MURATA VIRULENCE OF H PILORI 2416All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
GUENTHER GROWTH SPHERICAL VS ADHERENT UP 2115All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283177All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 2 3023All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN 7652All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU UP 5337All SZGR 2.0 genes in this pathway
TCGA GLIOBLASTOMA COPY NUMBER UP 7536All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266171All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 14396All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL CIS 12877All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL CIS 7551All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL CIS 6538All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
FERRANDO LYL1 NEIGHBORS 1512All SZGR 2.0 genes in this pathway
COLLER MYC TARGETS UP 2519All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER EARLY RECURRENCE 1110All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP 12684All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT UP 165100All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318215All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163115All SZGR 2.0 genes in this pathway
WANG IMMORTALIZED BY HOXA9 AND MEIS1 UP 3124All SZGR 2.0 genes in this pathway
RORIE TARGETS OF EWSR1 FLI1 FUSION UP 3022All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP 11484All SZGR 2.0 genes in this pathway
WANG TARGETS OF MLL CBP FUSION DN 4531All SZGR 2.0 genes in this pathway
TAVOR CEBPA TARGETS UP 4836All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246180All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151103All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C8 7256All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS UP 3727All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP 175116All SZGR 2.0 genes in this pathway
SIMBULAN PARP1 TARGETS UP 3123All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT 5141All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN 6444All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN 9867All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261183All SZGR 2.0 genes in this pathway
HAN JNK SINGALING UP 3521All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS PRENATAL 4233All SZGR 2.0 genes in this pathway
LIANG SILENCED BY METHYLATION UP 3218All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428266All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
LOPES METHYLATED IN COLON CANCER UP 2720All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS 212121All SZGR 2.0 genes in this pathway
SANSOM WNT PATHWAY REQUIRE MYC 5843All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292189All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP 11580All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
HOQUE METHYLATED IN CANCER 5645All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250168All SZGR 2.0 genes in this pathway
MATZUK EARLY ANTRAL FOLLICLE 1311All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1 9175All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A UP 10457All SZGR 2.0 genes in this pathway
LU TUMOR ANGIOGENESIS UP 2522All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C CLUSTER DN 3221All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252155All SZGR 2.0 genes in this pathway
REICHERT G1S REGULATORS AS PI3K TARGETS 86All SZGR 2.0 genes in this pathway
ROSS LEUKEMIA WITH MLL FUSIONS 7849All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS DN 7450All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE DN 7561All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP 7049All SZGR 2.0 genes in this pathway
HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE DN 5036All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP 221150All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
MIKKELSEN PLURIPOTENT STATE DN 87All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA 4327All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS UP 7445All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP 8961All SZGR 2.0 genes in this pathway
LEE LIVER CANCER HEPATOBLAST 1612All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP 10575All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
LI PROSTATE CANCER EPIGENETIC 3022All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA3 UP 8054All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237159All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP 143100All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335193All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307182All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS 7762All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217131All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 2 UP 1512All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP 12170All SZGR 2.0 genes in this pathway
AZARE STAT3 TARGETS 2412All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP 11687All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
YU BAP1 TARGETS 2921All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489314All SZGR 2.0 genes in this pathway