Summary ?
GeneID8976
SymbolWASL
SynonymsN-WASP|NWASP|WASPB
DescriptionWiskott-Aldrich syndrome-like
ReferenceMIM:605056|HGNC:HGNC:12735|Ensembl:ENSG00000106299|HPRD:05448|Vega:OTTHUMG00000157346
Gene typeprotein-coding
Map location7q31.3
Pascal p-value0.001
Sherlock p-value0.078
SupportSTRUCTURAL PLASTICITY
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZFYVE280.900.84
STIM10.870.84
CAMTA20.870.86
CNTNAP10.870.84
AC105206.10.860.82
NPTN0.860.81
ABLIM20.860.83
KCNAB20.860.88
MAST30.860.87
SLC35F30.860.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BCL7C-0.57-0.63
C9orf46-0.53-0.55
TUBB2B-0.51-0.50
RPS20-0.51-0.61
RPL27A-0.51-0.63
RBMX2-0.50-0.51
RPL18-0.50-0.59
YBX1-0.50-0.44
RPS8-0.50-0.56
PPP1R14B-0.50-0.56

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)in vitro
Reconstituted Complex
BioGRID9422512 |10781580 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD9422512 |10724160 
CTTNEMS1 | FLJ34459cortactin-HPRD,BioGRID11830518 
DNMBPKIAA1010 | TUBAdynamin binding protein-HPRD,BioGRID14506234 
FNBP1LC1orf39 | TOCA1formin binding protein 1-like-HPRD15260990 
FNBP1LC1orf39 | TOCA1formin binding protein 1-likeToca-1 interacts with N-WASP. This interaction was modelled on a demonstrated interaction between Toca-1 from human and N-WASP from rat.BIND15260990 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID10087612 |10781580 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1WASL (N-WASP) interacts with HSPCA (HSP90-alpha).BIND15791211 
HSP90AB1D6S182 | FLJ26984 | HSP90-BETA | HSP90B | HSPC2 | HSPCBheat shock protein 90kDa alpha (cytosolic), class B member 1WASL (N-WASP) interacts with HSPCB (HSP90-beta).BIND15791211 
ITSN1ITSN | MGC134948 | MGC134949 | SH3D1A | SH3P17intersectin 1 (SH3 domain protein)-HPRD,BioGRID11584276 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD,BioGRID11340081 
NCKIPSDAF3P21 | DIP | DIP1 | MGC23891 | ORF1 | SPIN90 | WASLBP | WISHNCK interacting protein with SH3 domain-HPRD11157975 
PACSIN1KIAA1379 | SDPIprotein kinase C and casein kinase substrate in neurons 1-HPRD9950691|11179684 
PACSIN1KIAA1379 | SDPIprotein kinase C and casein kinase substrate in neurons 1Reconstituted ComplexBioGRID11082044 
PACSIN2SDPIIprotein kinase C and casein kinase substrate in neurons 2Reconstituted ComplexBioGRID11082044 
PACSIN3SDPIIIprotein kinase C and casein kinase substrate in neurons 3-HPRD,BioGRID11082044 
PFN1-profilin 1-HPRD,BioGRID9822597 
PRPF40AFBP-11 | FBP11 | FLAF1 | FLJ20585 | FNBP3 | HIP10 | HYPA | NY-REN-6PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)-HPRD14697212 
RHOQARHQ | RASL7A | TC10 | TC10Aras homolog gene family, member Q-HPRD,BioGRID12456725 
VIPR1FLJ41949 | HVR1 | II | PACAP-R-2 | RDC1 | VAPC1 | VIPR | VIRG | VPAC1 | VPCAP1Rvasoactive intestinal peptide receptor 1-HPRD,BioGRID10867004 
WIPF1MGC111041 | PRPL-2 | WASPIP | WIPWAS/WASL interacting protein family, member 1-HPRD,BioGRID10087612 |12372256 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION 7553All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 9771All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION 5936All SZGR 2.0 genes in this pathway
BIOCARTA SALMONELLA PATHWAY 1310All SZGR 2.0 genes in this pathway
BIOCARTA CDC42RAC PATHWAY 1613All SZGR 2.0 genes in this pathway
BIOCARTA ACTINY PATHWAY 2014All SZGR 2.0 genes in this pathway
SIG CHEMOTAXIS 4537All SZGR 2.0 genes in this pathway
SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES 3525All SZGR 2.0 genes in this pathway
PID MET PATHWAY 8060All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 4038All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 7051All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY 3227All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY 3529All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 10578All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
PID NEPHRIN NEPH1 PATHWAY 3124All SZGR 2.0 genes in this pathway
PID FAK PATHWAY 5945All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION 12077All SZGR 2.0 genes in this pathway
REACTOME ENOS ACTIVATION AND REGULATION 2014All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251188All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING 4130All SZGR 2.0 genes in this pathway
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING 1311All SZGR 2.0 genes in this pathway
REACTOME NEPHRIN INTERACTIONS 2015All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408247All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS UP 9457All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244147All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP 177110All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352225All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN 240171All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN 209122All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A UP 191128All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK DN 13797All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP 197135All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382224All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411249All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240152All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 10573All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA DN 10063All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414237All SZGR 2.0 genes in this pathway