Gene Page: WASL
Summary ?
| GeneID | 8976 |
| Symbol | WASL |
| Synonyms | N-WASP|NWASP|WASPB |
| Description | Wiskott-Aldrich syndrome-like |
| Reference | MIM:605056|HGNC:HGNC:12735|Ensembl:ENSG00000106299|HPRD:05448|Vega:OTTHUMG00000157346 |
| Gene type | protein-coding |
| Map location | 7q31.3 |
| Pascal p-value | 0.001 |
| Sherlock p-value | 0.078 |
| Support | STRUCTURAL PLASTICITY G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZFYVE28 | 0.90 | 0.84 |
| STIM1 | 0.87 | 0.84 |
| CAMTA2 | 0.87 | 0.86 |
| CNTNAP1 | 0.87 | 0.84 |
| AC105206.1 | 0.86 | 0.82 |
| NPTN | 0.86 | 0.81 |
| ABLIM2 | 0.86 | 0.83 |
| KCNAB2 | 0.86 | 0.88 |
| MAST3 | 0.86 | 0.87 |
| SLC35F3 | 0.86 | 0.81 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BCL7C | -0.57 | -0.63 |
| C9orf46 | -0.53 | -0.55 |
| TUBB2B | -0.51 | -0.50 |
| RPS20 | -0.51 | -0.61 |
| RPL27A | -0.51 | -0.63 |
| RBMX2 | -0.50 | -0.51 |
| RPL18 | -0.50 | -0.59 |
| YBX1 | -0.50 | -0.44 |
| RPS8 | -0.50 | -0.56 |
| PPP1R14B | -0.50 | -0.56 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CDC42 | CDC42Hs | G25K | cell division cycle 42 (GTP binding protein, 25kDa) | in vitro Reconstituted Complex | BioGRID | 9422512 |10781580 |
| CDC42 | CDC42Hs | G25K | cell division cycle 42 (GTP binding protein, 25kDa) | - | HPRD | 9422512 |10724160 |
| CTTN | EMS1 | FLJ34459 | cortactin | - | HPRD,BioGRID | 11830518 |
| DNMBP | KIAA1010 | TUBA | dynamin binding protein | - | HPRD,BioGRID | 14506234 |
| FNBP1L | C1orf39 | TOCA1 | formin binding protein 1-like | - | HPRD | 15260990 |
| FNBP1L | C1orf39 | TOCA1 | formin binding protein 1-like | Toca-1 interacts with N-WASP. This interaction was modelled on a demonstrated interaction between Toca-1 from human and N-WASP from rat. | BIND | 15260990 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD,BioGRID | 10087612 |10781580 |
| HSP90AA1 | FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | WASL (N-WASP) interacts with HSPCA (HSP90-alpha). | BIND | 15791211 |
| HSP90AB1 | D6S182 | FLJ26984 | HSP90-BETA | HSP90B | HSPC2 | HSPCB | heat shock protein 90kDa alpha (cytosolic), class B member 1 | WASL (N-WASP) interacts with HSPCB (HSP90-beta). | BIND | 15791211 |
| ITSN1 | ITSN | MGC134948 | MGC134949 | SH3D1A | SH3P17 | intersectin 1 (SH3 domain protein) | - | HPRD,BioGRID | 11584276 |
| NCK1 | MGC12668 | NCK | NCKalpha | NCK adaptor protein 1 | - | HPRD,BioGRID | 11340081 |
| NCKIPSD | AF3P21 | DIP | DIP1 | MGC23891 | ORF1 | SPIN90 | WASLBP | WISH | NCK interacting protein with SH3 domain | - | HPRD | 11157975 |
| PACSIN1 | KIAA1379 | SDPI | protein kinase C and casein kinase substrate in neurons 1 | - | HPRD | 9950691|11179684 |
| PACSIN1 | KIAA1379 | SDPI | protein kinase C and casein kinase substrate in neurons 1 | Reconstituted Complex | BioGRID | 11082044 |
| PACSIN2 | SDPII | protein kinase C and casein kinase substrate in neurons 2 | Reconstituted Complex | BioGRID | 11082044 |
| PACSIN3 | SDPIII | protein kinase C and casein kinase substrate in neurons 3 | - | HPRD,BioGRID | 11082044 |
| PFN1 | - | profilin 1 | - | HPRD,BioGRID | 9822597 |
| PRPF40A | FBP-11 | FBP11 | FLAF1 | FLJ20585 | FNBP3 | HIP10 | HYPA | NY-REN-6 | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | - | HPRD | 14697212 |
| RHOQ | ARHQ | RASL7A | TC10 | TC10A | ras homolog gene family, member Q | - | HPRD,BioGRID | 12456725 |
| VIPR1 | FLJ41949 | HVR1 | II | PACAP-R-2 | RDC1 | VAPC1 | VIPR | VIRG | VPAC1 | VPCAP1R | vasoactive intestinal peptide receptor 1 | - | HPRD,BioGRID | 10867004 |
| WIPF1 | MGC111041 | PRPL-2 | WASPIP | WIP | WAS/WASL interacting protein family, member 1 | - | HPRD,BioGRID | 10087612 |12372256 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CHEMOKINE SIGNALING PATHWAY | 190 | 128 | All SZGR 2.0 genes in this pathway |
| KEGG ADHERENS JUNCTION | 75 | 53 | All SZGR 2.0 genes in this pathway |
| KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS | 97 | 71 | All SZGR 2.0 genes in this pathway |
| KEGG REGULATION OF ACTIN CYTOSKELETON | 216 | 144 | All SZGR 2.0 genes in this pathway |
| KEGG PATHOGENIC ESCHERICHIA COLI INFECTION | 59 | 36 | All SZGR 2.0 genes in this pathway |
| BIOCARTA SALMONELLA PATHWAY | 13 | 10 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CDC42RAC PATHWAY | 16 | 13 | All SZGR 2.0 genes in this pathway |
| BIOCARTA ACTINY PATHWAY | 20 | 14 | All SZGR 2.0 genes in this pathway |
| SIG CHEMOTAXIS | 45 | 37 | All SZGR 2.0 genes in this pathway |
| SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | 35 | 25 | All SZGR 2.0 genes in this pathway |
| PID MET PATHWAY | 80 | 60 | All SZGR 2.0 genes in this pathway |
| PID EPHB FWD PATHWAY | 40 | 38 | All SZGR 2.0 genes in this pathway |
| PID CDC42 PATHWAY | 70 | 51 | All SZGR 2.0 genes in this pathway |
| PID NETRIN PATHWAY | 32 | 27 | All SZGR 2.0 genes in this pathway |
| PID ERBB1 RECEPTOR PROXIMAL PATHWAY | 35 | 29 | All SZGR 2.0 genes in this pathway |
| PID ERBB1 DOWNSTREAM PATHWAY | 105 | 78 | All SZGR 2.0 genes in this pathway |
| PID PDGFRB PATHWAY | 129 | 103 | All SZGR 2.0 genes in this pathway |
| PID NEPHRIN NEPH1 PATHWAY | 31 | 24 | All SZGR 2.0 genes in this pathway |
| PID FAK PATHWAY | 59 | 45 | All SZGR 2.0 genes in this pathway |
| REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CELL COMMUNICATION | 120 | 77 | All SZGR 2.0 genes in this pathway |
| REACTOME ENOS ACTIVATION AND REGULATION | 20 | 14 | All SZGR 2.0 genes in this pathway |
| REACTOME AXON GUIDANCE | 251 | 188 | All SZGR 2.0 genes in this pathway |
| REACTOME NETRIN1 SIGNALING | 41 | 30 | All SZGR 2.0 genes in this pathway |
| REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | 13 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME NEPHRIN INTERACTIONS | 20 | 15 | All SZGR 2.0 genes in this pathway |
| SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP | 408 | 247 | All SZGR 2.0 genes in this pathway |
| HOOI ST7 TARGETS UP | 94 | 57 | All SZGR 2.0 genes in this pathway |
| THUM SYSTOLIC HEART FAILURE DN | 244 | 147 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP | 177 | 110 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS DN | 352 | 225 | All SZGR 2.0 genes in this pathway |
| UDAYAKUMAR MED1 TARGETS DN | 240 | 171 | All SZGR 2.0 genes in this pathway |
| KIM WT1 TARGETS 12HR DN | 209 | 122 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS A UP | 191 | 128 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 5 6WK DN | 137 | 97 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 6 7WK UP | 197 | 135 | All SZGR 2.0 genes in this pathway |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN | 382 | 224 | All SZGR 2.0 genes in this pathway |
| KOYAMA SEMA3B TARGETS DN | 411 | 249 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 20HR UP | 240 | 152 | All SZGR 2.0 genes in this pathway |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP | 314 | 201 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 8HR UP | 105 | 73 | All SZGR 2.0 genes in this pathway |
| QI PLASMACYTOMA DN | 100 | 63 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS SENESCENT | 572 | 352 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS DN | 414 | 237 | All SZGR 2.0 genes in this pathway |