Gene Page: SIGLEC10
Summary ?
| GeneID | 89790 |
| Symbol | SIGLEC10 |
| Synonyms | PRO940|SIGLEC-10|SLG2 |
| Description | sialic acid binding Ig like lectin 10 |
| Reference | MIM:606091|HGNC:HGNC:15620|Ensembl:ENSG00000142512|HPRD:07307|Vega:OTTHUMG00000165521 |
| Gene type | protein-coding |
| Map location | 19q13.3 |
| Pascal p-value | 0.762 |
| Fetal beta | -0.637 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:vanEijk_2014 | Genome-wide DNA methylation analysis | This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg11459714 | 19 | 51520658 | SIGLEC10 | 0.001 | -7.147 | DMG:vanEijk_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10116858 | chr9 | 20300988 | SIGLEC10 | 89790 | 0.04 | trans | ||
| rs3802522 | chr10 | 28341865 | SIGLEC10 | 89790 | 0.13 | trans | ||
| rs10508730 | chr10 | 28403391 | SIGLEC10 | 89790 | 0.13 | trans | ||
| rs10743139 | chr11 | 10425326 | SIGLEC10 | 89790 | 0.06 | trans | ||
| rs10770432 | chr12 | 19234389 | SIGLEC10 | 89790 | 0.12 | trans | ||
| rs11178166 | chr12 | 70670585 | SIGLEC10 | 89790 | 0.12 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS DN | 431 | 263 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS F DN | 33 | 24 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP | 397 | 206 | All SZGR 2.0 genes in this pathway |
| KATSANOU ELAVL1 TARGETS DN | 148 | 88 | All SZGR 2.0 genes in this pathway |