Gene Page: SIGLEC12
Summary ?
| GeneID | 89858 |
| Symbol | SIGLEC12 |
| Synonyms | S2V|SIGLECL1|SLG|Siglec-XII |
| Description | sialic acid binding Ig like lectin 12 (gene/pseudogene) |
| Reference | MIM:606094|HGNC:HGNC:15482|Ensembl:ENSG00000254521|HPRD:16195|Vega:OTTHUMG00000165524 |
| Gene type | protein-coding |
| Map location | 19q13.4 |
| Pascal p-value | 0.357 |
| Fetal beta | -0.045 |
| DMG | 1 (# studies) |
| eGene | Hypothalamus Nucleus accumbens basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg02957799 | 19 | 52003566 | SIGLEC12 | 4.622E-4 | -0.297 | 0.046 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| MUELLER PLURINET | 299 | 189 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN | 374 | 217 | All SZGR 2.0 genes in this pathway |