Gene Page: STARD13
Summary ?
GeneID | 90627 |
Symbol | STARD13 |
Synonyms | ARHGAP37|DLC2|GT650|LINC00464 |
Description | StAR related lipid transfer domain containing 13 |
Reference | MIM:609866|HGNC:HGNC:19164|Ensembl:ENSG00000133121|HPRD:11607|Vega:OTTHUMG00000016708 |
Gene type | protein-coding |
Map location | 13q13.1 |
Pascal p-value | 0.004 |
Sherlock p-value | 0.439 |
Fetal beta | -1.796 |
DMG | 2 (# studies) |
eGene | Nucleus accumbens basal ganglia |
Support | CompositeSet Ascano FMRP targets |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 2 |
DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
---|---|---|---|---|---|---|---|---|---|---|---|
STARD13 | chr13 | 33684161 | C | T | NM_001243476 NM_052851 NM_178006 NM_178007 | p.931V>I p.848V>I p.966V>I p.958V>I | missense missense missense missense | Schizophrenia | DNM:Fromer_2014 |
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg24469742 | 13 | 33773155 | STARD13 | 5.368E-4 | 0.416 | 0.048 | DMG:Wockner_2014 |
cg04240267 | 13 | 34116871 | STARD13 | 7.74E-11 | -0.016 | 4.34E-7 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005096 | GTPase activator activity | IEA | - | |
GO:0005515 | protein binding | IPI | 14697242 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0007165 | signal transduction | IEA | - | |
GO:0045786 | negative regulation of cell cycle | IEA | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005811 | lipid particle | IEA | - | |
GO:0005622 | intracellular | IEA | - | |
GO:0005737 | cytoplasm | IEA | - | |
GO:0005739 | mitochondrion | IEA | - | |
GO:0016020 | membrane | IEA | - | |
GO:0034430 | monolayer-surrounded lipid storage body outer lipid monolayer | IEA | - | |
GO:0031966 | mitochondrial membrane | IEA | - |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
BAI2 | - | brain-specific angiogenesis inhibitor 2 | STARD13 (RhoGAP) interacts with BAI2. | BIND | 14697242 |
BAI2 | - | brain-specific angiogenesis inhibitor 2 | - | HPRD,BioGRID | 14697242 |
CNTN2 | AXT | DKFZp781D102 | FLJ42746 | MGC157722 | TAG-1 | TAX | TAX1 | contactin 2 (axonal) | Affinity Capture-Western | BioGRID | 14697242 |
EPB41L1 | 4.1N | DKFZp686H17242 | KIAA0338 | MGC11072 | erythrocyte membrane protein band 4.1-like 1 | STARD13 (RhoGAP) interacts with EPB41L1 (KIAA0338). | BIND | 14697242 |
EPB41L1 | 4.1N | DKFZp686H17242 | KIAA0338 | MGC11072 | erythrocyte membrane protein band 4.1-like 1 | - | HPRD,BioGRID | 14697242 |
HMGCR | - | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | - | HPRD,BioGRID | 14697242 |
HMGCR | - | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | STARD13 (RhoGAP) interacts with HMGCR (HMG CoA reductase). | BIND | 14697242 |
HSP90AA1 | FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | Two-hybrid | BioGRID | 14697242 |
HSP90AB1 | D6S182 | FLJ26984 | HSP90-BETA | HSP90B | HSPC2 | HSPCB | heat shock protein 90kDa alpha (cytosolic), class B member 1 | STARD13 (RhoGAP) interacts with HSPCB. | BIND | 14697242 |
HSP90AB1 | D6S182 | FLJ26984 | HSP90-BETA | HSP90B | HSPC2 | HSPCB | heat shock protein 90kDa alpha (cytosolic), class B member 1 | - | HPRD | 14697242 |
ITPR1 | INSP3R1 | IP3R | IP3R1 | SCA15 | SCA16 | inositol 1,4,5-triphosphate receptor, type 1 | STARD13 (RhoGAP) interacts with ITPR1. | BIND | 14697242 |
ITPR1 | INSP3R1 | IP3R | IP3R1 | SCA15 | SCA16 | inositol 1,4,5-triphosphate receptor, type 1 | Two-hybrid | BioGRID | 14697242 |
KIF1B | CMT2 | CMT2A | CMT2A1 | FLJ23699 | HMSNII | KIAA0591 | KIAA1448 | KLP | MGC134844 | kinesin family member 1B | - | HPRD,BioGRID | 14697242 |
KIF1B | CMT2 | CMT2A | CMT2A1 | FLJ23699 | HMSNII | KIAA0591 | KIAA1448 | KLP | MGC134844 | kinesin family member 1B | STARD13 (RhoGAP) interacts with KIF1B. | BIND | 14697242 |
SMARCD3 | BAF60C | CRACD3 | MGC111010 | Rsc6p | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | STARD13 (RhoGAP) interacts with an unspecified isoform of SMARCD3 (SWI/SNF). | BIND | 14697242 |
SMARCD3 | BAF60C | CRACD3 | MGC111010 | Rsc6p | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | Two-hybrid | BioGRID | 14697242 |
TAX1BP1 | CALCOCO3 | T6BP | TXBP151 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | STARD13 (RhoGAP) interacts with TAX1BP1 (Tax1BP). | BIND | 14697242 |
TAX1BP1 | CALCOCO3 | T6BP | TXBP151 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | - | HPRD,BioGRID | 14697242 |
TRIM58 | BIA2 | DKFZp434C091 | tripartite motif-containing 58 | Two-hybrid | BioGRID | 14697242 |
TUBA1A | B-ALPHA-1 | FLJ25113 | LIS3 | TUBA3 | tubulin, alpha 1a | Affinity Capture-Western Two-hybrid | BioGRID | 14697242 |
TUBA1B | K-ALPHA-1 | tubulin, alpha 1b | STARD13 (RhoGAP) interacts with K-ALPHA-1 (alpha-tubulin). | BIND | 14697242 |
TUBA4A | FLJ30169 | H2-ALPHA | TUBA1 | tubulin, alpha 4a | - | HPRD | 14697242 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
REACTOME SIGNALING BY RHO GTPASES | 113 | 81 | All SZGR 2.0 genes in this pathway |
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN | 169 | 118 | All SZGR 2.0 genes in this pathway |
SOTIRIOU BREAST CANCER GRADE 1 VS 3 DN | 52 | 34 | All SZGR 2.0 genes in this pathway |
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN | 537 | 339 | All SZGR 2.0 genes in this pathway |
DELYS THYROID CANCER DN | 232 | 154 | All SZGR 2.0 genes in this pathway |
VANHARANTA UTERINE FIBROID UP | 45 | 26 | All SZGR 2.0 genes in this pathway |
ODONNELL METASTASIS UP | 82 | 58 | All SZGR 2.0 genes in this pathway |
DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | All SZGR 2.0 genes in this pathway |
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN | 483 | 336 | All SZGR 2.0 genes in this pathway |
DAIRKEE TERT TARGETS DN | 124 | 79 | All SZGR 2.0 genes in this pathway |
ONDER CDH1 TARGETS 2 UP | 256 | 159 | All SZGR 2.0 genes in this pathway |
ONDER CDH1 TARGETS 1 DN | 169 | 102 | All SZGR 2.0 genes in this pathway |
ZHANG TARGETS OF EWSR1 FLI1 FUSION | 88 | 68 | All SZGR 2.0 genes in this pathway |
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR | 681 | 420 | All SZGR 2.0 genes in this pathway |
XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | All SZGR 2.0 genes in this pathway |
MASSARWEH TAMOXIFEN RESISTANCE DN | 258 | 160 | All SZGR 2.0 genes in this pathway |
MASSARWEH RESPONSE TO ESTRADIOL | 61 | 47 | All SZGR 2.0 genes in this pathway |
BOCHKIS FOXA2 TARGETS | 425 | 261 | All SZGR 2.0 genes in this pathway |
CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 4HR DN | 254 | 158 | All SZGR 2.0 genes in this pathway |
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |
KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
let-7/98 | 2345 | 2351 | 1A | hsa-let-7abrain | UGAGGUAGUAGGUUGUAUAGUU |
hsa-let-7bbrain | UGAGGUAGUAGGUUGUGUGGUU | ||||
hsa-let-7cbrain | UGAGGUAGUAGGUUGUAUGGUU | ||||
hsa-let-7dbrain | AGAGGUAGUAGGUUGCAUAGU | ||||
hsa-let-7ebrain | UGAGGUAGGAGGUUGUAUAGU | ||||
hsa-let-7fbrain | UGAGGUAGUAGAUUGUAUAGUU | ||||
hsa-miR-98brain | UGAGGUAGUAAGUUGUAUUGUU | ||||
hsa-let-7gSZ | UGAGGUAGUAGUUUGUACAGU | ||||
hsa-let-7ibrain | UGAGGUAGUAGUUUGUGCUGU | ||||
miR-125/351 | 24 | 31 | 1A,m8 | hsa-miR-125bbrain | UCCCUGAGACCCUAACUUGUGA |
hsa-miR-125abrain | UCCCUGAGACCCUUUAACCUGUG | ||||
hsa-miR-125bbrain | UCCCUGAGACCCUAACUUGUGA | ||||
hsa-miR-125abrain | UCCCUGAGACCCUUUAACCUGUG | ||||
miR-130/301 | 1010 | 1016 | m8 | hsa-miR-130abrain | CAGUGCAAUGUUAAAAGGGCAU |
hsa-miR-301 | CAGUGCAAUAGUAUUGUCAAAGC | ||||
hsa-miR-130bbrain | CAGUGCAAUGAUGAAAGGGCAU | ||||
hsa-miR-454-3p | UAGUGCAAUAUUGCUUAUAGGGUUU | ||||
miR-148/152 | 1011 | 1018 | 1A,m8 | hsa-miR-148a | UCAGUGCACUACAGAACUUUGU |
hsa-miR-152brain | UCAGUGCAUGACAGAACUUGGG | ||||
hsa-miR-148b | UCAGUGCAUCACAGAACUUUGU | ||||
miR-182 | 2404 | 2410 | m8 | hsa-miR-182 | UUUGGCAAUGGUAGAACUCACA |
miR-324-5p | 2029 | 2035 | m8 | hsa-miR-324-5p | CGCAUCCCCUAGGGCAUUGGUGU |
miR-369-3p | 2334 | 2340 | 1A | hsa-miR-369-3p | AAUAAUACAUGGUUGAUCUUU |
miR-374 | 2334 | 2340 | m8 | hsa-miR-374 | UUAUAAUACAACCUGAUAAGUG |
miR-410 | 399 | 405 | 1A | hsa-miR-410 | AAUAUAACACAGAUGGCCUGU |
miR-9 | 560 | 567 | 1A,m8 | hsa-miR-9SZ | UCUUUGGUUAUCUAGCUGUAUGA |
hsa-miR-9SZ | UCUUUGGUUAUCUAGCUGUAUGA |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.