Summary ?
GeneID9063
SymbolPIAS2
SynonymsARIP3|DIP|MIZ|MIZ1|PIASX|PIASX-ALPHA|PIASX-BETA|SIZ2|ZMIZ4
Descriptionprotein inhibitor of activated STAT 2
ReferenceMIM:603567|HGNC:HGNC:17311|Ensembl:ENSG00000078043|HPRD:06944|Vega:OTTHUMG00000179301
Gene typeprotein-coding
Map location18q21.1
Pascal p-value0.004
Fetal beta-0.575

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RNF2130.730.72
IKBKB0.710.71
FLNB0.700.69
FUBP30.670.67
FNBP10.660.69
PPFIA10.660.65
NEK90.650.68
WWC20.650.70
CAPN20.650.65
TEP10.640.65
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C17orf61-0.46-0.48
COX7B-0.45-0.43
TMEM126A-0.45-0.43
AC044839.2-0.45-0.33
C1orf54-0.44-0.35
UQCRQ-0.44-0.42
USMG5-0.43-0.40
NDUFA2-0.43-0.42
UQCR-0.43-0.46
CLEC2B-0.43-0.32

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1Miz1 interacts with Akt.BIND15580267 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorReconstituted Complex
Two-hybrid
BioGRID9920921 |11117529 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)Miz1 interacts with p-P21CIP1.BIND15580267 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)Miz-1 interacts with CDKN1A promoter.BIND15780936 
CDKN1CBWCR | BWS | KIP2 | WBS | p57cyclin-dependent kinase inhibitor 1C (p57, Kip2)Miz1 interacts with p-P57KIP2.BIND15580267 
CDKN2BCDK4I | INK4B | MTS2 | P15 | TP15 | p15INK4bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)Miz1 interacts with p-p15Ink4b.BIND15580267 
CDV3H41CDV3 homolog (mouse)Miz1 interacts with p-H41 transcription start site.BIND15580267 
DNMT3ADNMT3A2 | M.HsaIIIADNA (cytosine-5-)-methyltransferase 3 alphaAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID14752048 
ELK1-ELK1, member of ETS oncogene familyELK1 interacts with PIAS2a (PIASX-alpha).BIND15920481 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Reconstituted ComplexBioGRID11117529 
ESR2ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2estrogen receptor 2 (ER beta)Reconstituted ComplexBioGRID11117529 
GTF2IRD1BEN | CREAM1 | GTF3 | MUSTRD1 | RBAP2 | WBS | WBSCR11 | WBSCR12 | hMusTRD1alpha1GTF2I repeat domain containing 1Reconstituted ComplexBioGRID12193603 
GTF2IRD1BEN | CREAM1 | GTF3 | MUSTRD1 | RBAP2 | WBS | WBSCR11 | WBSCR12 | hMusTRD1alpha1GTF2I repeat domain containing 1hMusTRD1 interacts with PIASx-beta. This interaction was modeled on a demonstrated interaction between human hMusTRD1 and mouse PIASx-beta.BIND12193603 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Affinity Capture-WesternBioGRID11283613 
NAV2FLJ10633 | FLJ11030 | FLJ23707 | FLJ77876 | HELAD1 | KIAA1419 | POMFIL2 | RAINB1 | STEERIN2 | UNC53H2neuron navigator 2Two-hybridBioGRID16189514 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)Reconstituted ComplexBioGRID11117529 
PARK7DJ-1 | DJ1 | FLJ27376 | FLJ34360 | FLJ92274Parkinson disease (autosomal recessive, early onset) 7-HPRD,BioGRID11477070 
PGRNR3C3 | PRprogesterone receptorReconstituted ComplexBioGRID11117529 
PIAS1DDXBP1 | GBP | GU/RH-II | MGC141878 | MGC141879 | ZMIZ3protein inhibitor of activated STAT, 1-HPRD11877418 
STAT4SLEB11signal transducer and activator of transcription 4-HPRD,BioGRID12716907 
SUMO1DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)SUMO-1 interacts with PIASxbeta.BIND14609633 
SUMO1DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)Two-hybridBioGRID14609633 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Two-hybridBioGRID14609633 |16189514 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Ubc9 interacts with PIASxb-eta.BIND14609633 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptideMiz1 interacts with 14-3-3 eta.BIND15580267 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 13898All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155105All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER 8467All SZGR 2.0 genes in this pathway
PID RANBP2 PATHWAY 1111All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY 3329All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP 164122All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 7751All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION CCNE1 4026All SZGR 2.0 genes in this pathway
IWANAGA E2F1 TARGETS INDUCED BY SERUM 3119All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176115All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 12589All SZGR 2.0 genes in this pathway
WEBER METHYLATED HCP IN SPERM DN 2813All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
PALOMERO GSI SENSITIVITY UP 76All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238145All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR EVASION AND TOLEROGENICITY UP 3019All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 2 UP 5431All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP 17097All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 4 UP 11264All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 5 UP 128All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 UP 14081All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 7 UP 11868All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway