Gene Page: PIAS2
Summary ?
| GeneID | 9063 |
| Symbol | PIAS2 |
| Synonyms | ARIP3|DIP|MIZ|MIZ1|PIASX|PIASX-ALPHA|PIASX-BETA|SIZ2|ZMIZ4 |
| Description | protein inhibitor of activated STAT 2 |
| Reference | MIM:603567|HGNC:HGNC:17311|Ensembl:ENSG00000078043|HPRD:06944|Vega:OTTHUMG00000179301 |
| Gene type | protein-coding |
| Map location | 18q21.1 |
| Pascal p-value | 0.004 |
| Fetal beta | -0.575 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RNF213 | 0.73 | 0.72 |
| IKBKB | 0.71 | 0.71 |
| FLNB | 0.70 | 0.69 |
| FUBP3 | 0.67 | 0.67 |
| FNBP1 | 0.66 | 0.69 |
| PPFIA1 | 0.66 | 0.65 |
| NEK9 | 0.65 | 0.68 |
| WWC2 | 0.65 | 0.70 |
| CAPN2 | 0.65 | 0.65 |
| TEP1 | 0.64 | 0.65 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C17orf61 | -0.46 | -0.48 |
| COX7B | -0.45 | -0.43 |
| TMEM126A | -0.45 | -0.43 |
| AC044839.2 | -0.45 | -0.33 |
| C1orf54 | -0.44 | -0.35 |
| UQCRQ | -0.44 | -0.42 |
| USMG5 | -0.43 | -0.40 |
| NDUFA2 | -0.43 | -0.42 |
| UQCR | -0.43 | -0.46 |
| CLEC2B | -0.43 | -0.32 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AKT1 | AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 | Miz1 interacts with Akt. | BIND | 15580267 |
| AR | AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM | androgen receptor | Reconstituted Complex Two-hybrid | BioGRID | 9920921 |11117529 |
| CDKN1A | CAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Miz1 interacts with p-P21CIP1. | BIND | 15580267 |
| CDKN1A | CAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Miz-1 interacts with CDKN1A promoter. | BIND | 15780936 |
| CDKN1C | BWCR | BWS | KIP2 | WBS | p57 | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | Miz1 interacts with p-P57KIP2. | BIND | 15580267 |
| CDKN2B | CDK4I | INK4B | MTS2 | P15 | TP15 | p15INK4b | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | Miz1 interacts with p-p15Ink4b. | BIND | 15580267 |
| CDV3 | H41 | CDV3 homolog (mouse) | Miz1 interacts with p-H41 transcription start site. | BIND | 15580267 |
| DNMT3A | DNMT3A2 | M.HsaIIIA | DNA (cytosine-5-)-methyltransferase 3 alpha | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 14752048 |
| ELK1 | - | ELK1, member of ETS oncogene family | ELK1 interacts with PIAS2a (PIASX-alpha). | BIND | 15920481 |
| ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | estrogen receptor 1 | Reconstituted Complex | BioGRID | 11117529 |
| ESR2 | ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2 | estrogen receptor 2 (ER beta) | Reconstituted Complex | BioGRID | 11117529 |
| GTF2IRD1 | BEN | CREAM1 | GTF3 | MUSTRD1 | RBAP2 | WBS | WBSCR11 | WBSCR12 | hMusTRD1alpha1 | GTF2I repeat domain containing 1 | Reconstituted Complex | BioGRID | 12193603 |
| GTF2IRD1 | BEN | CREAM1 | GTF3 | MUSTRD1 | RBAP2 | WBS | WBSCR11 | WBSCR12 | hMusTRD1alpha1 | GTF2I repeat domain containing 1 | hMusTRD1 interacts with PIASx-beta. This interaction was modeled on a demonstrated interaction between human hMusTRD1 and mouse PIASx-beta. | BIND | 12193603 |
| MYC | bHLHe39 | c-Myc | v-myc myelocytomatosis viral oncogene homolog (avian) | Affinity Capture-Western | BioGRID | 11283613 |
| NAV2 | FLJ10633 | FLJ11030 | FLJ23707 | FLJ77876 | HELAD1 | KIAA1419 | POMFIL2 | RAINB1 | STEERIN2 | UNC53H2 | neuron navigator 2 | Two-hybrid | BioGRID | 16189514 |
| NR3C1 | GCCR | GCR | GR | GRL | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Reconstituted Complex | BioGRID | 11117529 |
| PARK7 | DJ-1 | DJ1 | FLJ27376 | FLJ34360 | FLJ92274 | Parkinson disease (autosomal recessive, early onset) 7 | - | HPRD,BioGRID | 11477070 |
| PGR | NR3C3 | PR | progesterone receptor | Reconstituted Complex | BioGRID | 11117529 |
| PIAS1 | DDXBP1 | GBP | GU/RH-II | MGC141878 | MGC141879 | ZMIZ3 | protein inhibitor of activated STAT, 1 | - | HPRD | 11877418 |
| STAT4 | SLEB11 | signal transducer and activator of transcription 4 | - | HPRD,BioGRID | 12716907 |
| SUMO1 | DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) | SUMO-1 interacts with PIASxbeta. | BIND | 14609633 |
| SUMO1 | DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) | Two-hybrid | BioGRID | 14609633 |
| UBE2I | C358B7.1 | P18 | UBC9 | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | Two-hybrid | BioGRID | 14609633 |16189514 |
| UBE2I | C358B7.1 | P18 | UBC9 | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | Ubc9 interacts with PIASxb-eta. | BIND | 14609633 |
| YWHAH | YWHA1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | Miz1 interacts with 14-3-3 eta. | BIND | 15580267 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG UBIQUITIN MEDIATED PROTEOLYSIS | 138 | 98 | All SZGR 2.0 genes in this pathway |
| KEGG JAK STAT SIGNALING PATHWAY | 155 | 105 | All SZGR 2.0 genes in this pathway |
| KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
| KEGG SMALL CELL LUNG CANCER | 84 | 67 | All SZGR 2.0 genes in this pathway |
| PID RANBP2 PATHWAY | 11 | 11 | All SZGR 2.0 genes in this pathway |
| PID IL12 STAT4 PATHWAY | 33 | 29 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| KIM WT1 TARGETS 8HR UP | 164 | 122 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| RIZ ERYTHROID DIFFERENTIATION | 77 | 51 | All SZGR 2.0 genes in this pathway |
| RIZ ERYTHROID DIFFERENTIATION CCNE1 | 40 | 26 | All SZGR 2.0 genes in this pathway |
| IWANAGA E2F1 TARGETS INDUCED BY SERUM | 31 | 19 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 6HR UP | 176 | 115 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS UP | 566 | 371 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 | 720 | 440 | All SZGR 2.0 genes in this pathway |
| ZHENG BOUND BY FOXP3 | 491 | 310 | All SZGR 2.0 genes in this pathway |
| STEARMAN LUNG CANCER EARLY VS LATE UP | 125 | 89 | All SZGR 2.0 genes in this pathway |
| WEBER METHYLATED HCP IN SPERM DN | 28 | 13 | All SZGR 2.0 genes in this pathway |
| MUELLER PLURINET | 299 | 189 | All SZGR 2.0 genes in this pathway |
| PALOMERO GSI SENSITIVITY UP | 7 | 6 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER DN | 238 | 145 | All SZGR 2.0 genes in this pathway |
| WORSCHECH TUMOR EVASION AND TOLEROGENICITY UP | 30 | 19 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 2 UP | 54 | 31 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 UP | 170 | 97 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 4 UP | 112 | 64 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 5 UP | 12 | 8 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 6 UP | 140 | 81 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 7 UP | 118 | 68 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS UP | 279 | 155 | All SZGR 2.0 genes in this pathway |