Gene Page: MAP3K6

Summary ?
GeneID9064
SymbolMAP3K6
SynonymsASK2|MAPKKK6|MEKK6
Descriptionmitogen-activated protein kinase kinase kinase 6
ReferenceMIM:604468|HGNC:HGNC:6858|Ensembl:ENSG00000142733|HPRD:05126|Vega:OTTHUMG00000004631
Gene typeprotein-coding
Map location1p36.11
Pascal p-value0.435
Sherlock p-value0.839
Fetal beta-0.629
DMG1 (# studies)
eGeneCortex
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg11705208127683386MAP3K62.39E-50.3790.017DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6753548chr22268763MAP3K690640.14trans
rs16829545chr2151977407MAP3K690643.549E-5trans
rs16955618chr1529937543MAP3K690642.919E-7trans
rs11873184chr181584081MAP3K690640.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NARG10.960.97
SERBP10.950.94
TOP10.950.97
WDR30.950.96
SMEK20.950.96
SUPT16H0.950.97
ZMYM40.950.96
BCLAF10.950.97
PPP2R5E0.950.95
CSGALNACT20.950.95
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.70-0.87
FXYD1-0.70-0.88
MT-CO2-0.69-0.88
IFI27-0.69-0.87
HLA-F-0.69-0.76
TSC22D4-0.68-0.80
C5orf53-0.68-0.73
AF347015.27-0.68-0.84
AIFM3-0.68-0.76
AF347015.33-0.68-0.83

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 8768All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY 2621All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP 11679All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 2 7252All SZGR 2.0 genes in this pathway
BILD MYC ONCOGENIC SIGNATURE 206117All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235144All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS UP 4025All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A4 196124All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 10772All SZGR 2.0 genes in this pathway
DURAND STROMA NS UP 162103All SZGR 2.0 genes in this pathway