Gene Page: SEC11C

Summary ?
GeneID90701
SymbolSEC11C
SynonymsSEC11L3|SPC21|SPCS4C
DescriptionSEC11 homolog C, signal peptidase complex subunit
ReferenceHGNC:HGNC:23400|Ensembl:ENSG00000166562|HPRD:15310|Vega:OTTHUMG00000132762
Gene typeprotein-coding
Map location18q21.32
Pascal p-value0.136
Fetal beta-0.509
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2809658chr143050395SEC11C907010.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008236serine-type peptidase activityIEAglutamate (GO term level: 6)-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006465signal peptide processingIEA-
GO:0006508proteolysisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeIEA-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PROTEIN EXPORT 2416All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION 22275All SZGR 2.0 genes in this pathway
REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE 17953All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM 12084All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION 9365All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 1611All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP 148All SZGR 2.0 genes in this pathway
REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION 2214All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 1912All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE UP 8657All SZGR 2.0 genes in this pathway
MORI PLASMA CELL UP 5129All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 UP 11169All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
KRIEG KDM3A TARGETS NOT HYPOXIA 208107All SZGR 2.0 genes in this pathway