Gene Page: PIGQ
Summary ?
| GeneID | 9091 |
| Symbol | PIGQ |
| Synonyms | GPI1|c407A10.1 |
| Description | phosphatidylinositol glycan anchor biosynthesis class Q |
| Reference | MIM:605754|HGNC:HGNC:14135|Ensembl:ENSG00000007541|HPRD:09307|Vega:OTTHUMG00000168047 |
| Gene type | protein-coding |
| Map location | 16p13.3 |
| Pascal p-value | 0.122 |
| Fetal beta | 0.099 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
| Support | CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg06486124 | 16 | 619677 | PIGQ | 3.833E-4 | -0.268 | 0.043 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs35324776 | 16 | 619897 | PIGQ | ENSG00000007541.10 | 2.456E-7 | 0.01 | -50 | gtex_brain_ba24 |
| rs2097540 | 16 | 621321 | PIGQ | ENSG00000007541.10 | 1.606E-6 | 0.01 | 1374 | gtex_brain_ba24 |
| rs4984891 | 16 | 622234 | PIGQ | ENSG00000007541.10 | 4.079E-7 | 0.01 | 2287 | gtex_brain_ba24 |
| rs4984892 | 16 | 622325 | PIGQ | ENSG00000007541.10 | 4.034E-7 | 0.01 | 2378 | gtex_brain_ba24 |
| rs12917944 | 16 | 622565 | PIGQ | ENSG00000007541.10 | 4.27E-7 | 0.01 | 2618 | gtex_brain_ba24 |
| rs4984668 | 16 | 622761 | PIGQ | ENSG00000007541.10 | 5.338E-7 | 0.01 | 2814 | gtex_brain_ba24 |
| rs4984893 | 16 | 623082 | PIGQ | ENSG00000007541.10 | 3.591E-7 | 0.01 | 3135 | gtex_brain_ba24 |
| rs4984894 | 16 | 623103 | PIGQ | ENSG00000007541.10 | 3.295E-7 | 0.01 | 3156 | gtex_brain_ba24 |
| rs4984895 | 16 | 623238 | PIGQ | ENSG00000007541.10 | 3.527E-7 | 0.01 | 3291 | gtex_brain_ba24 |
| rs2071979 | 16 | 624114 | PIGQ | ENSG00000007541.10 | 2.082E-7 | 0.01 | 4167 | gtex_brain_ba24 |
| rs4984669 | 16 | 624713 | PIGQ | ENSG00000007541.10 | 4.119E-7 | 0.01 | 4766 | gtex_brain_ba24 |
| rs2384978 | 16 | 625384 | PIGQ | ENSG00000007541.10 | 2.075E-7 | 0.01 | 5437 | gtex_brain_ba24 |
| rs2384977 | 16 | 625388 | PIGQ | ENSG00000007541.10 | 2.079E-7 | 0.01 | 5441 | gtex_brain_ba24 |
| rs4984896 | 16 | 625493 | PIGQ | ENSG00000007541.10 | 2.079E-7 | 0.01 | 5546 | gtex_brain_ba24 |
| rs2071980 | 16 | 626346 | PIGQ | ENSG00000007541.10 | 2.081E-7 | 0.01 | 6399 | gtex_brain_ba24 |
| rs10903017 | 16 | 627920 | PIGQ | ENSG00000007541.10 | 2.089E-7 | 0.01 | 7973 | gtex_brain_ba24 |
| rs3752567 | 16 | 628130 | PIGQ | ENSG00000007541.10 | 2.089E-7 | 0.01 | 8183 | gtex_brain_ba24 |
| rs3752568 | 16 | 628302 | PIGQ | ENSG00000007541.10 | 2.089E-7 | 0.01 | 8355 | gtex_brain_ba24 |
| rs397799298 | 16 | 628994 | PIGQ | ENSG00000007541.10 | 1.112E-7 | 0.01 | 9047 | gtex_brain_ba24 |
| rs35666389 | 16 | 629458 | PIGQ | ENSG00000007541.10 | 1.615E-6 | 0.01 | 9511 | gtex_brain_ba24 |
| rs2071981 | 16 | 630025 | PIGQ | ENSG00000007541.10 | 2.092E-7 | 0.01 | 10078 | gtex_brain_ba24 |
| rs7191939 | 16 | 630089 | PIGQ | ENSG00000007541.10 | 2.143E-7 | 0.01 | 10142 | gtex_brain_ba24 |
| rs7192508 | 16 | 630367 | PIGQ | ENSG00000007541.10 | 2.092E-7 | 0.01 | 10420 | gtex_brain_ba24 |
| rs2071982 | 16 | 630405 | PIGQ | ENSG00000007541.10 | 2.092E-7 | 0.01 | 10458 | gtex_brain_ba24 |
| rs1981483 | 16 | 630665 | PIGQ | ENSG00000007541.10 | 2.092E-7 | 0.01 | 10718 | gtex_brain_ba24 |
| rs1981484 | 16 | 630710 | PIGQ | ENSG00000007541.10 | 2.092E-7 | 0.01 | 10763 | gtex_brain_ba24 |
| rs4580163 | 16 | 631752 | PIGQ | ENSG00000007541.10 | 1.77E-6 | 0.01 | 11805 | gtex_brain_ba24 |
| rs2018789 | 16 | 632051 | PIGQ | ENSG00000007541.10 | 2.08E-7 | 0.01 | 12104 | gtex_brain_ba24 |
| rs916414 | 16 | 632073 | PIGQ | ENSG00000007541.10 | 2.08E-7 | 0.01 | 12126 | gtex_brain_ba24 |
| rs916415 | 16 | 632115 | PIGQ | ENSG00000007541.10 | 2.08E-7 | 0.01 | 12168 | gtex_brain_ba24 |
| rs4984897 | 16 | 632180 | PIGQ | ENSG00000007541.10 | 2.08E-7 | 0.01 | 12233 | gtex_brain_ba24 |
| rs916416 | 16 | 632198 | PIGQ | ENSG00000007541.10 | 2.016E-7 | 0.01 | 12251 | gtex_brain_ba24 |
| rs4006748 | 16 | 632225 | PIGQ | ENSG00000007541.10 | 2.109E-7 | 0.01 | 12278 | gtex_brain_ba24 |
| rs67976359 | 16 | 632230 | PIGQ | ENSG00000007541.10 | 1.055E-7 | 0.01 | 12283 | gtex_brain_ba24 |
| rs11331057 | 16 | 632232 | PIGQ | ENSG00000007541.10 | 1.056E-7 | 0.01 | 12285 | gtex_brain_ba24 |
| rs3743901 | 16 | 632699 | PIGQ | ENSG00000007541.10 | 2.082E-7 | 0.01 | 12752 | gtex_brain_ba24 |
| rs3743902 | 16 | 632728 | PIGQ | ENSG00000007541.10 | 2.082E-7 | 0.01 | 12781 | gtex_brain_ba24 |
| rs3743903 | 16 | 632736 | PIGQ | ENSG00000007541.10 | 2.082E-7 | 0.01 | 12789 | gtex_brain_ba24 |
| rs3743904 | 16 | 632767 | PIGQ | ENSG00000007541.10 | 2.266E-7 | 0.01 | 12820 | gtex_brain_ba24 |
| rs1045277 | 16 | 633125 | PIGQ | ENSG00000007541.10 | 2.082E-7 | 0.01 | 13178 | gtex_brain_ba24 |
| rs8675 | 16 | 633843 | PIGQ | ENSG00000007541.10 | 1.654E-7 | 0.01 | 13896 | gtex_brain_ba24 |
| rs8909 | 16 | 633851 | PIGQ | ENSG00000007541.10 | 1.658E-7 | 0.01 | 13904 | gtex_brain_ba24 |
| rs114814269 | 16 | 634170 | PIGQ | ENSG00000007541.10 | 2.987E-7 | 0.01 | 14223 | gtex_brain_ba24 |
| rs11643039 | 16 | 634260 | PIGQ | ENSG00000007541.10 | 1.609E-7 | 0.01 | 14313 | gtex_brain_ba24 |
| rs3833074 | 16 | 634313 | PIGQ | ENSG00000007541.10 | 1.734E-6 | 0.01 | 14366 | gtex_brain_ba24 |
| rs59164425 | 16 | 634791 | PIGQ | ENSG00000007541.10 | 1.433E-7 | 0.01 | 14844 | gtex_brain_ba24 |
| rs56048717 | 16 | 634867 | PIGQ | ENSG00000007541.10 | 1.688E-7 | 0.01 | 14920 | gtex_brain_ba24 |
| rs11648728 | 16 | 635525 | PIGQ | ENSG00000007541.10 | 2.059E-7 | 0.01 | 15578 | gtex_brain_ba24 |
| rs8060585 | 16 | 635794 | PIGQ | ENSG00000007541.10 | 2.017E-7 | 0.01 | 15847 | gtex_brain_ba24 |
| rs8060921 | 16 | 635988 | PIGQ | ENSG00000007541.10 | 3.27E-7 | 0.01 | 16041 | gtex_brain_ba24 |
| rs7199839 | 16 | 636126 | PIGQ | ENSG00000007541.10 | 2.065E-7 | 0.01 | 16179 | gtex_brain_ba24 |
| rs2017567 | 16 | 637212 | PIGQ | ENSG00000007541.10 | 2.063E-7 | 0.01 | 17265 | gtex_brain_ba24 |
| rs62030902 | 16 | 638264 | PIGQ | ENSG00000007541.10 | 3.019E-7 | 0.01 | 18317 | gtex_brain_ba24 |
| rs62030903 | 16 | 638323 | PIGQ | ENSG00000007541.10 | 3.019E-7 | 0.01 | 18376 | gtex_brain_ba24 |
| rs4984670 | 16 | 641044 | PIGQ | ENSG00000007541.10 | 5.848E-7 | 0.01 | 21097 | gtex_brain_ba24 |
| rs4984898 | 16 | 641164 | PIGQ | ENSG00000007541.10 | 2.962E-7 | 0.01 | 21217 | gtex_brain_ba24 |
| rs35642938 | 16 | 642249 | PIGQ | ENSG00000007541.10 | 3.045E-7 | 0.01 | 22302 | gtex_brain_ba24 |
| rs7205409 | 16 | 642610 | PIGQ | ENSG00000007541.10 | 1.15E-6 | 0.01 | 22663 | gtex_brain_ba24 |
| rs4144003 | 16 | 645968 | PIGQ | ENSG00000007541.10 | 2.01E-7 | 0.01 | 26021 | gtex_brain_ba24 |
| rs2384975 | 16 | 651115 | PIGQ | ENSG00000007541.10 | 2.893E-7 | 0.01 | 31168 | gtex_brain_ba24 |
| rs2384974 | 16 | 651279 | PIGQ | ENSG00000007541.10 | 2.898E-7 | 0.01 | 31332 | gtex_brain_ba24 |
| rs4984901 | 16 | 652623 | PIGQ | ENSG00000007541.10 | 4.956E-7 | 0.01 | 32676 | gtex_brain_ba24 |
| rs4247097 | 16 | 654224 | PIGQ | ENSG00000007541.10 | 3.679E-7 | 0.01 | 34277 | gtex_brain_ba24 |
| rs8050792 | 16 | 656033 | PIGQ | ENSG00000007541.10 | 4.685E-7 | 0.01 | 36086 | gtex_brain_ba24 |
| rs7204439 | 16 | 661335 | PIGQ | ENSG00000007541.10 | 5.208E-7 | 0.01 | 41388 | gtex_brain_ba24 |
| rs7198877 | 16 | 661439 | PIGQ | ENSG00000007541.10 | 5.132E-7 | 0.01 | 41492 | gtex_brain_ba24 |
| rs34498660 | 16 | 666149 | PIGQ | ENSG00000007541.10 | 6.424E-7 | 0.01 | 46202 | gtex_brain_ba24 |
| rs7191397 | 16 | 666517 | PIGQ | ENSG00000007541.10 | 6.876E-7 | 0.01 | 46570 | gtex_brain_ba24 |
| rs34011309 | 16 | 668443 | PIGQ | ENSG00000007541.10 | 6.323E-7 | 0.01 | 48496 | gtex_brain_ba24 |
| rs4984675 | 16 | 670117 | PIGQ | ENSG00000007541.10 | 1.357E-6 | 0.01 | 50170 | gtex_brain_ba24 |
| rs4984676 | 16 | 670168 | PIGQ | ENSG00000007541.10 | 1.515E-6 | 0.01 | 50221 | gtex_brain_ba24 |
| rs4984677 | 16 | 671682 | PIGQ | ENSG00000007541.10 | 1.325E-6 | 0.01 | 51735 | gtex_brain_ba24 |
| rs2384972 | 16 | 674424 | PIGQ | ENSG00000007541.10 | 1.32E-6 | 0.01 | 54477 | gtex_brain_ba24 |
| rs763014 | 16 | 675680 | PIGQ | ENSG00000007541.10 | 1.323E-6 | 0.01 | 55733 | gtex_brain_ba24 |
| rs15564 | 16 | 677854 | PIGQ | ENSG00000007541.10 | 1.288E-6 | 0.01 | 57907 | gtex_brain_ba24 |
| rs4984903 | 16 | 680695 | PIGQ | ENSG00000007541.10 | 1.437E-6 | 0.01 | 60748 | gtex_brain_ba24 |
| rs4984904 | 16 | 680809 | PIGQ | ENSG00000007541.10 | 1.288E-6 | 0.01 | 60862 | gtex_brain_ba24 |
| rs28455838 | 16 | 681966 | PIGQ | ENSG00000007541.10 | 1.204E-6 | 0.01 | 62019 | gtex_brain_ba24 |
| rs2269558 | 16 | 682250 | PIGQ | ENSG00000007541.10 | 9.425E-7 | 0.01 | 62303 | gtex_brain_ba24 |
| rs2269559 | 16 | 682297 | PIGQ | ENSG00000007541.10 | 9.52E-7 | 0.01 | 62350 | gtex_brain_ba24 |
| rs2269560 | 16 | 682442 | PIGQ | ENSG00000007541.10 | 9.411E-7 | 0.01 | 62495 | gtex_brain_ba24 |
| rs4984890 | 16 | 612698 | PIGQ | ENSG00000007541.10 | 2.824E-8 | 0 | -7249 | gtex_brain_putamen_basal |
| rs35903260 | 16 | 613147 | PIGQ | ENSG00000007541.10 | 2.458E-7 | 0 | -6800 | gtex_brain_putamen_basal |
| rs12597975 | 16 | 613168 | PIGQ | ENSG00000007541.10 | 5.729E-8 | 0 | -6779 | gtex_brain_putamen_basal |
| rs59985111 | 16 | 615326 | PIGQ | ENSG00000007541.10 | 5.188E-9 | 0 | -4621 | gtex_brain_putamen_basal |
| rs35324776 | 16 | 619897 | PIGQ | ENSG00000007541.10 | 9.69E-9 | 0 | -50 | gtex_brain_putamen_basal |
| rs2097540 | 16 | 621321 | PIGQ | ENSG00000007541.10 | 3.368E-10 | 0 | 1374 | gtex_brain_putamen_basal |
| rs4984891 | 16 | 622234 | PIGQ | ENSG00000007541.10 | 1.546E-11 | 0 | 2287 | gtex_brain_putamen_basal |
| rs4984892 | 16 | 622325 | PIGQ | ENSG00000007541.10 | 9.308E-12 | 0 | 2378 | gtex_brain_putamen_basal |
| rs12917944 | 16 | 622565 | PIGQ | ENSG00000007541.10 | 8.85E-12 | 0 | 2618 | gtex_brain_putamen_basal |
| rs4984668 | 16 | 622761 | PIGQ | ENSG00000007541.10 | 8.89E-12 | 0 | 2814 | gtex_brain_putamen_basal |
| rs4984893 | 16 | 623082 | PIGQ | ENSG00000007541.10 | 8.587E-12 | 0 | 3135 | gtex_brain_putamen_basal |
| rs4984894 | 16 | 623103 | PIGQ | ENSG00000007541.10 | 6.707E-12 | 0 | 3156 | gtex_brain_putamen_basal |
| rs4984895 | 16 | 623238 | PIGQ | ENSG00000007541.10 | 8.453E-12 | 0 | 3291 | gtex_brain_putamen_basal |
| rs2071979 | 16 | 624114 | PIGQ | ENSG00000007541.10 | 3.355E-12 | 0 | 4167 | gtex_brain_putamen_basal |
| rs4984669 | 16 | 624713 | PIGQ | ENSG00000007541.10 | 5.121E-12 | 0 | 4766 | gtex_brain_putamen_basal |
| rs2384978 | 16 | 625384 | PIGQ | ENSG00000007541.10 | 3.354E-12 | 0 | 5437 | gtex_brain_putamen_basal |
| rs2384977 | 16 | 625388 | PIGQ | ENSG00000007541.10 | 3.358E-12 | 0 | 5441 | gtex_brain_putamen_basal |
| rs4984896 | 16 | 625493 | PIGQ | ENSG00000007541.10 | 3.358E-12 | 0 | 5546 | gtex_brain_putamen_basal |
| rs2071980 | 16 | 626346 | PIGQ | ENSG00000007541.10 | 3.056E-12 | 0 | 6399 | gtex_brain_putamen_basal |
| rs10903017 | 16 | 627920 | PIGQ | ENSG00000007541.10 | 3.455E-12 | 0 | 7973 | gtex_brain_putamen_basal |
| rs3752567 | 16 | 628130 | PIGQ | ENSG00000007541.10 | 3.455E-12 | 0 | 8183 | gtex_brain_putamen_basal |
| rs3752568 | 16 | 628302 | PIGQ | ENSG00000007541.10 | 3.454E-12 | 0 | 8355 | gtex_brain_putamen_basal |
| rs397799298 | 16 | 628994 | PIGQ | ENSG00000007541.10 | 1.604E-11 | 0 | 9047 | gtex_brain_putamen_basal |
| rs35666389 | 16 | 629458 | PIGQ | ENSG00000007541.10 | 9.318E-11 | 0 | 9511 | gtex_brain_putamen_basal |
| rs2071981 | 16 | 630025 | PIGQ | ENSG00000007541.10 | 3.463E-12 | 0 | 10078 | gtex_brain_putamen_basal |
| rs7191939 | 16 | 630089 | PIGQ | ENSG00000007541.10 | 4.538E-12 | 0 | 10142 | gtex_brain_putamen_basal |
| rs7192508 | 16 | 630367 | PIGQ | ENSG00000007541.10 | 3.466E-12 | 0 | 10420 | gtex_brain_putamen_basal |
| rs2071982 | 16 | 630405 | PIGQ | ENSG00000007541.10 | 3.463E-12 | 0 | 10458 | gtex_brain_putamen_basal |
| rs1981483 | 16 | 630665 | PIGQ | ENSG00000007541.10 | 3.466E-12 | 0 | 10718 | gtex_brain_putamen_basal |
| rs1981484 | 16 | 630710 | PIGQ | ENSG00000007541.10 | 3.463E-12 | 0 | 10763 | gtex_brain_putamen_basal |
| rs4580163 | 16 | 631752 | PIGQ | ENSG00000007541.10 | 4.708E-11 | 0 | 11805 | gtex_brain_putamen_basal |
| rs2018789 | 16 | 632051 | PIGQ | ENSG00000007541.10 | 3.455E-12 | 0 | 12104 | gtex_brain_putamen_basal |
| rs916414 | 16 | 632073 | PIGQ | ENSG00000007541.10 | 3.457E-12 | 0 | 12126 | gtex_brain_putamen_basal |
| rs916415 | 16 | 632115 | PIGQ | ENSG00000007541.10 | 3.457E-12 | 0 | 12168 | gtex_brain_putamen_basal |
| rs4262946 | 16 | 632138 | PIGQ | ENSG00000007541.10 | 2.613E-10 | 0 | 12191 | gtex_brain_putamen_basal |
| rs4984897 | 16 | 632180 | PIGQ | ENSG00000007541.10 | 3.457E-12 | 0 | 12233 | gtex_brain_putamen_basal |
| rs916416 | 16 | 632198 | PIGQ | ENSG00000007541.10 | 3.448E-12 | 0 | 12251 | gtex_brain_putamen_basal |
| rs4006748 | 16 | 632225 | PIGQ | ENSG00000007541.10 | 3.439E-12 | 0 | 12278 | gtex_brain_putamen_basal |
| rs67976359 | 16 | 632230 | PIGQ | ENSG00000007541.10 | 9.835E-12 | 0 | 12283 | gtex_brain_putamen_basal |
| rs11331057 | 16 | 632232 | PIGQ | ENSG00000007541.10 | 5.331E-12 | 0 | 12285 | gtex_brain_putamen_basal |
| rs3743901 | 16 | 632699 | PIGQ | ENSG00000007541.10 | 4.832E-12 | 0 | 12752 | gtex_brain_putamen_basal |
| rs3743902 | 16 | 632728 | PIGQ | ENSG00000007541.10 | 3.453E-12 | 0 | 12781 | gtex_brain_putamen_basal |
| rs3743903 | 16 | 632736 | PIGQ | ENSG00000007541.10 | 3.45E-12 | 0 | 12789 | gtex_brain_putamen_basal |
| rs3743904 | 16 | 632767 | PIGQ | ENSG00000007541.10 | 3.367E-12 | 0 | 12820 | gtex_brain_putamen_basal |
| rs1045277 | 16 | 633125 | PIGQ | ENSG00000007541.10 | 3.453E-12 | 0 | 13178 | gtex_brain_putamen_basal |
| rs710924 | 16 | 633353 | PIGQ | ENSG00000007541.10 | 4.901E-13 | 0 | 13406 | gtex_brain_putamen_basal |
| rs710925 | 16 | 633354 | PIGQ | ENSG00000007541.10 | 4.888E-13 | 0 | 13407 | gtex_brain_putamen_basal |
| rs8675 | 16 | 633843 | PIGQ | ENSG00000007541.10 | 3.582E-12 | 0 | 13896 | gtex_brain_putamen_basal |
| rs8909 | 16 | 633851 | PIGQ | ENSG00000007541.10 | 3.581E-12 | 0 | 13904 | gtex_brain_putamen_basal |
| rs201162387 | 16 | 634169 | PIGQ | ENSG00000007541.10 | 1.155E-9 | 0 | 14222 | gtex_brain_putamen_basal |
| rs114814269 | 16 | 634170 | PIGQ | ENSG00000007541.10 | 5.039E-11 | 0 | 14223 | gtex_brain_putamen_basal |
| rs11643039 | 16 | 634260 | PIGQ | ENSG00000007541.10 | 3.606E-12 | 0 | 14313 | gtex_brain_putamen_basal |
| rs3833074 | 16 | 634313 | PIGQ | ENSG00000007541.10 | 3.609E-11 | 0 | 14366 | gtex_brain_putamen_basal |
| rs59164425 | 16 | 634791 | PIGQ | ENSG00000007541.10 | 3.197E-12 | 0 | 14844 | gtex_brain_putamen_basal |
| rs56048717 | 16 | 634867 | PIGQ | ENSG00000007541.10 | 4.029E-12 | 0 | 14920 | gtex_brain_putamen_basal |
| rs11648728 | 16 | 635525 | PIGQ | ENSG00000007541.10 | 3.419E-12 | 0 | 15578 | gtex_brain_putamen_basal |
| rs8060585 | 16 | 635794 | PIGQ | ENSG00000007541.10 | 3.431E-12 | 0 | 15847 | gtex_brain_putamen_basal |
| rs8060921 | 16 | 635988 | PIGQ | ENSG00000007541.10 | 4.167E-12 | 0 | 16041 | gtex_brain_putamen_basal |
| rs7199839 | 16 | 636126 | PIGQ | ENSG00000007541.10 | 9.831E-13 | 0 | 16179 | gtex_brain_putamen_basal |
| rs2017567 | 16 | 637212 | PIGQ | ENSG00000007541.10 | 9.842E-13 | 0 | 17265 | gtex_brain_putamen_basal |
| rs62030902 | 16 | 638264 | PIGQ | ENSG00000007541.10 | 8.898E-12 | 0 | 18317 | gtex_brain_putamen_basal |
| rs62030903 | 16 | 638323 | PIGQ | ENSG00000007541.10 | 8.895E-12 | 0 | 18376 | gtex_brain_putamen_basal |
| rs4984670 | 16 | 641044 | PIGQ | ENSG00000007541.10 | 2.296E-11 | 0 | 21097 | gtex_brain_putamen_basal |
| rs4984898 | 16 | 641164 | PIGQ | ENSG00000007541.10 | 1.572E-11 | 0 | 21217 | gtex_brain_putamen_basal |
| rs35642938 | 16 | 642249 | PIGQ | ENSG00000007541.10 | 8.907E-13 | 0 | 22302 | gtex_brain_putamen_basal |
| rs7205409 | 16 | 642610 | PIGQ | ENSG00000007541.10 | 4.171E-11 | 0 | 22663 | gtex_brain_putamen_basal |
| rs4144003 | 16 | 645968 | PIGQ | ENSG00000007541.10 | 9.422E-13 | 0 | 26021 | gtex_brain_putamen_basal |
| rs35067229 | 16 | 649638 | PIGQ | ENSG00000007541.10 | 8.129E-13 | 0 | 29691 | gtex_brain_putamen_basal |
| rs2384975 | 16 | 651115 | PIGQ | ENSG00000007541.10 | 9.422E-13 | 0 | 31168 | gtex_brain_putamen_basal |
| rs2384974 | 16 | 651279 | PIGQ | ENSG00000007541.10 | 9.422E-13 | 0 | 31332 | gtex_brain_putamen_basal |
| rs4984901 | 16 | 652623 | PIGQ | ENSG00000007541.10 | 9.422E-13 | 0 | 32676 | gtex_brain_putamen_basal |
| rs4247097 | 16 | 654224 | PIGQ | ENSG00000007541.10 | 9.409E-13 | 0 | 34277 | gtex_brain_putamen_basal |
| rs8050792 | 16 | 656033 | PIGQ | ENSG00000007541.10 | 2E-12 | 0 | 36086 | gtex_brain_putamen_basal |
| rs12922012 | 16 | 657552 | PIGQ | ENSG00000007541.10 | 8.824E-11 | 0 | 37605 | gtex_brain_putamen_basal |
| rs7204439 | 16 | 661335 | PIGQ | ENSG00000007541.10 | 7.877E-12 | 0 | 41388 | gtex_brain_putamen_basal |
| rs7198877 | 16 | 661439 | PIGQ | ENSG00000007541.10 | 9.399E-13 | 0 | 41492 | gtex_brain_putamen_basal |
| rs9745918 | 16 | 664196 | PIGQ | ENSG00000007541.10 | 3.092E-11 | 0 | 44249 | gtex_brain_putamen_basal |
| rs34498660 | 16 | 666149 | PIGQ | ENSG00000007541.10 | 1.153E-12 | 0 | 46202 | gtex_brain_putamen_basal |
| rs7185390 | 16 | 666382 | PIGQ | ENSG00000007541.10 | 3.725E-9 | 0 | 46435 | gtex_brain_putamen_basal |
| rs7191397 | 16 | 666517 | PIGQ | ENSG00000007541.10 | 1.386E-11 | 0 | 46570 | gtex_brain_putamen_basal |
| rs34011309 | 16 | 668443 | PIGQ | ENSG00000007541.10 | 1.086E-12 | 0 | 48496 | gtex_brain_putamen_basal |
| rs4984675 | 16 | 670117 | PIGQ | ENSG00000007541.10 | 2.14E-12 | 0 | 50170 | gtex_brain_putamen_basal |
| rs4984676 | 16 | 670168 | PIGQ | ENSG00000007541.10 | 3.033E-13 | 0 | 50221 | gtex_brain_putamen_basal |
| rs12935215 | 16 | 670605 | PIGQ | ENSG00000007541.10 | 1.258E-13 | 0 | 50658 | gtex_brain_putamen_basal |
| rs4984677 | 16 | 671682 | PIGQ | ENSG00000007541.10 | 2.653E-13 | 0 | 51735 | gtex_brain_putamen_basal |
| rs8054842 | 16 | 672799 | PIGQ | ENSG00000007541.10 | 8.458E-11 | 0 | 52852 | gtex_brain_putamen_basal |
| rs12444525 | 16 | 673430 | PIGQ | ENSG00000007541.10 | 8.731E-9 | 0 | 53483 | gtex_brain_putamen_basal |
| rs2384972 | 16 | 674424 | PIGQ | ENSG00000007541.10 | 2.619E-13 | 0 | 54477 | gtex_brain_putamen_basal |
| rs763014 | 16 | 675680 | PIGQ | ENSG00000007541.10 | 2.621E-13 | 0 | 55733 | gtex_brain_putamen_basal |
| rs15564 | 16 | 677854 | PIGQ | ENSG00000007541.10 | 2.589E-13 | 0 | 57907 | gtex_brain_putamen_basal |
| rs4984903 | 16 | 680695 | PIGQ | ENSG00000007541.10 | 9.058E-13 | 0 | 60748 | gtex_brain_putamen_basal |
| rs4984904 | 16 | 680809 | PIGQ | ENSG00000007541.10 | 1.012E-12 | 0 | 60862 | gtex_brain_putamen_basal |
| rs111471079 | 16 | 681741 | PIGQ | ENSG00000007541.10 | 1.19E-6 | 0 | 61794 | gtex_brain_putamen_basal |
| rs28455838 | 16 | 681966 | PIGQ | ENSG00000007541.10 | 5.757E-13 | 0 | 62019 | gtex_brain_putamen_basal |
| rs35800913 | 16 | 682041 | PIGQ | ENSG00000007541.10 | 5.061E-7 | 0 | 62094 | gtex_brain_putamen_basal |
| rs2269558 | 16 | 682250 | PIGQ | ENSG00000007541.10 | 5.122E-13 | 0 | 62303 | gtex_brain_putamen_basal |
| rs2269559 | 16 | 682297 | PIGQ | ENSG00000007541.10 | 5.121E-13 | 0 | 62350 | gtex_brain_putamen_basal |
| rs2269560 | 16 | 682442 | PIGQ | ENSG00000007541.10 | 5.114E-13 | 0 | 62495 | gtex_brain_putamen_basal |
| rs1810458 | 16 | 695287 | PIGQ | ENSG00000007541.10 | 1.916E-6 | 0 | 75340 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ABR | 0.88 | 0.88 |
| MADD | 0.87 | 0.87 |
| SLITRK1 | 0.87 | 0.89 |
| SLC25A44 | 0.85 | 0.85 |
| ASPHD2 | 0.85 | 0.87 |
| PHACTR1 | 0.85 | 0.88 |
| RUNDC1 | 0.85 | 0.87 |
| FBXL18 | 0.85 | 0.87 |
| BRPF3 | 0.84 | 0.87 |
| DOCK3 | 0.84 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.60 | -0.59 |
| AL139819.3 | -0.58 | -0.62 |
| GNG11 | -0.58 | -0.61 |
| AP002478.3 | -0.58 | -0.60 |
| C1orf54 | -0.57 | -0.66 |
| MT-CO2 | -0.56 | -0.55 |
| HIGD1B | -0.56 | -0.56 |
| AF347015.31 | -0.56 | -0.54 |
| DBI | -0.55 | -0.63 |
| RHOC | -0.55 | -0.61 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GLYCOSYLPHOSPHATIDYLINOSITOL GPI ANCHOR BIOSYNTHESIS | 25 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF PROTEINS | 518 | 242 | All SZGR 2.0 genes in this pathway |
| REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | 26 | 19 | All SZGR 2.0 genes in this pathway |
| REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION | 188 | 116 | All SZGR 2.0 genes in this pathway |
| REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | 17 | 12 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN | 234 | 147 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE UP | 134 | 93 | All SZGR 2.0 genes in this pathway |
| GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN | 206 | 136 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 16P13 AMPLICON | 120 | 49 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS MATURE CELL | 293 | 160 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS DN | 543 | 317 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS DN | 593 | 372 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS DN | 591 | 366 | All SZGR 2.0 genes in this pathway |
| MOOTHA PGC | 420 | 269 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 | 143 | 86 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 1HR DN | 222 | 147 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |
| ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP | 289 | 184 | All SZGR 2.0 genes in this pathway |