Gene Page: USP14

Summary
GeneID  9097
Symbol  USP14
Synonyms  TGT
Description  ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
See related  HGNC:12612|MIM:607274|Ensembl:ENSG00000101557|HPRD:06279|
Locus tag  -
Gene type  protein-coding
Map location  18p11.32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TP53BP10.950.96
ZRANB10.950.95
PUM10.940.95
VPS390.940.95
FBXW20.940.93
NFX10.940.95
FAM161B0.930.95
RABGEF10.930.94
AP003115.10.930.96
CKAP50.930.95
Top 10 negatively co-expressed genes
AF347015.31-0.83-0.87
MT-CO2-0.82-0.87
FXYD1-0.81-0.84
AF347015.21-0.79-0.89
HIGD1B-0.79-0.84
AF347015.27-0.79-0.84
AF347015.33-0.78-0.82
AF347015.8-0.78-0.85
MT-CYB-0.78-0.82
IFI27-0.77-0.82
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004197cysteine-type endopeptidase activityTAS9827704 
GO:0004221ubiquitin thiolesterase activityIEA-
GO:0008193tRNA guanylyltransferase activityTAS8579355 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionIEAneuron, Synap, Neurotransmitter (GO term level: 6)-
GO:0006464protein modification processIEA-
GO:0006511ubiquitin-dependent protein catabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0005625soluble fractionIEA-
GO:0005737cytoplasmIDA18029348 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FANCCFA3 | FAC | FACC | FLJ14675Fanconi anemia, complementation group CTwo-hybridBioGRID14499622 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
STONER_ESOPHAGEAL_CARCINOGENESIS_UP 3925All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP 7752All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
WONG_PROTEASOME_GENE_MODULE 4935All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_2G 17196All SZGR genes in this pathway
WILSON_PROTEASES_AT_TUMOR_BONE_INTERFACE_UP 2114All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
VANASSE_BCL2_TARGETS_DN 7450All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_DN 6948All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SURVIVAL_DN 11376All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_8 4936All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_C 9260All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1426432m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506226322701A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-15/16/195/424/497494500m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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