SZGR2

Summary ?

GeneID	9108
Symbol	MTMR7
Synonyms	-
Description	myotubularin related protein 7
Reference	MIM:603562\|HGNC:HGNC:7454\|Ensembl:ENSG00000003987\|HPRD:16027\|Vega:OTTHUMG00000163771
Gene type	protein-coding
Map location	8p22
Pascal p-value	0.002
Sherlock p-value	0.174
eGene	Cortex Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_I	Genome scan meta-analysis	Psr: 0.031
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.03086
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.00057

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs16916054	chr11	91158732	MTMR7	9108	0.11	trans
rs17650385	chr13	87104244	MTMR7	9108	0.12	trans
rs1480958	chr15	100575654	MTMR7	9108	0.01	trans
rs2727185	chr15	100576786	MTMR7	9108	0.04	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IEA		-
GO:0004725	protein tyrosine phosphatase activity	TAS		9736772
GO:0004437	inositol or phosphatidylinositol phosphatase activity	IEA		-
GO:0016787	hydrolase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006470	protein amino acid dephosphorylation	TAS		9736772
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	IEA		-
GO:0005624	membrane fraction	IEA		-
GO:0005634	nucleus	IDA		18029348
GO:0005737	cytoplasm	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG FRUCTOSE AND MANNOSE METABOLISM	34	23	All SZGR 2.0 genes in this pathway
KEGG RIBOFLAVIN METABOLISM	16	11	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM	198	112	All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	10	7	All SZGR 2.0 genes in this pathway
REACTOME PI METABOLISM	48	34	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR	532	309	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P6	91	44	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
TAVAZOIE METASTASIS	108	68	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2	491	319	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR UP	55	41	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-181	1208	1214	1A	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MTMR7