Gene Page: SLC16A3

Summary ?
GeneID9123
SymbolSLC16A3
SynonymsMCT 3|MCT 4|MCT-3|MCT-4|MCT3|MCT4
Descriptionsolute carrier family 16 member 3
ReferenceMIM:603877|HGNC:HGNC:10924|Ensembl:ENSG00000141526|HPRD:04854|Vega:OTTHUMG00000178832
Gene typeprotein-coding
Map location17q25
Pascal p-value0.033
Fetal beta-1.223
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg205310201780188598SLC16A34.005E-40.2490.044DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17013080chr1208862652SLC16A391230.01trans
rs4844714chr1208874118SLC16A391236.517E-5trans
rs10494904chr1208883320SLC16A391230trans
rs12097986chr1208883360SLC16A391230trans
rs10196963chr260437607SLC16A391230.19trans
rs4256179chr3169628328SLC16A391230.1trans
rs9870311chr3169641061SLC16A391230.1trans
rs9851931chr3191826057SLC16A391230.17trans
rs871474chr499562088SLC16A391230.2trans
rs16999761chr4107454800SLC16A391234.422E-5trans
rs7720858chr543419858SLC16A391230.18trans
rs4516856chr543889206SLC16A391230.02trans
rs16891983chr560806764SLC16A391230.1trans
rs7754123chr6132667231SLC16A391232.49E-4trans
rs10252088chr7144943367SLC16A391230.03trans
rs6989594chr8126303866SLC16A391230.05trans
rs4642688chr8136854953SLC16A391230.08trans
rs17455801chr1080310058SLC16A391230.13trans
rs10743139chr1110425326SLC16A391230.02trans
rs17076272chr1322726361SLC16A391233.72E-5trans
rs17076274chr1322726381SLC16A391233.72E-5trans
rs10483856chr1474365294SLC16A391230.05trans
rs12900069chr1586910986SLC16A391233.725E-4trans
rs8072151chr1750228268SLC16A391230.01trans
rs165126chr1875358831SLC16A391230.09trans
rs4814967chr2020209446SLC16A391230.16trans
rs16981724chr2020210644SLC16A391230.16trans
rs16979494chrX14301660SLC16A391230.03trans
rs5955544chrX19246404SLC16A391230.05trans
rs6527909chrX19265358SLC16A391230.1trans
rs16982879chrX92924110SLC16A391230.04trans
rs7879274chrX145592957SLC16A391231.052E-4trans
rs5980638chrX148196252SLC16A391230.07trans
rs5980645chrX148205604SLC16A391230.07trans
rs16995035chrX148268500SLC16A391230.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AGTRAP0.720.82
TRAF3IP20.700.74
TST0.700.79
RAMP10.680.81
NP0.670.66
RAB340.670.77
TMEM1490.670.61
TP53I130.660.66
IL17RB0.660.60
DECR10.660.69
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NELL2-0.55-0.71
DYNC1I1-0.55-0.66
FAM49A-0.54-0.69
GNAI1-0.54-0.68
CABYR-0.53-0.67
SPTAN1-0.53-0.66
STX3-0.53-0.68
DOCK9-0.53-0.60
AGTPBP1-0.52-0.68
LRRC7-0.52-0.64

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE 4832All SZGR 2.0 genes in this pathway
REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT 14185All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 9165All SZGR 2.0 genes in this pathway
REACTOME BASIGIN INTERACTIONS 3023All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241157All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 8954All SZGR 2.0 genes in this pathway
REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS 116All SZGR 2.0 genes in this pathway
REACTOME PYRUVATE METABOLISM 1914All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351230All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276187All SZGR 2.0 genes in this pathway
JAEGER METASTASIS UP 4423All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275168All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418263All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187115All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP 13582All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238144All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239157All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 2 4231All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA UP 2924All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA DN 4133All SZGR 2.0 genes in this pathway
MAINA HYPOXIA VHL TARGETS UP 65All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS DN 2417All SZGR 2.0 genes in this pathway
MAINA VHL TARGETS DN 1814All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261155All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176115All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
LEI HOXC8 TARGETS UP 1212All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318215All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183111All SZGR 2.0 genes in this pathway
LEONARD HYPOXIA 4735All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN 4934All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261166All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388234All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 15692All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
WONG MITOCHONDRIA GENE MODULE 217122All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270181All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS UP 4328All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315197All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS 4728All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL UP 4526All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456285All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288168All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP 188121All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP 178108All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 UP 8750All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216130All SZGR 2.0 genes in this pathway
QI HYPOXIA TARGETS OF HIF1A AND FOXA2 3727All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 3 UP 8950All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 4 11066All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway
DURAND STROMA NS UP 162103All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR DN 11469All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP 11068All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 8654All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway