Gene Page: KCNQ4
Summary ?
| GeneID | 9132 |
| Symbol | KCNQ4 |
| Synonyms | DFNA2|DFNA2A|KV7.4 |
| Description | potassium voltage-gated channel subfamily Q member 4 |
| Reference | MIM:603537|HGNC:HGNC:6298|Ensembl:ENSG00000117013|HPRD:04641|Vega:OTTHUMG00000007730 |
| Gene type | protein-coding |
| Map location | 1p34 |
| Pascal p-value | 0.013 |
| Fetal beta | -0.342 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10994209 | chr10 | 61877705 | KCNQ4 | 9132 | 0.17 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SMTN | 0.77 | 0.80 |
| LEPRE1 | 0.76 | 0.72 |
| LRDD | 0.75 | 0.74 |
| HDAC7 | 0.74 | 0.77 |
| FBXL6 | 0.74 | 0.72 |
| C7orf27 | 0.73 | 0.73 |
| AC004410.1 | 0.73 | 0.75 |
| ARHGAP17 | 0.73 | 0.70 |
| UCKL1 | 0.73 | 0.68 |
| LRCH4 | 0.73 | 0.73 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C5orf53 | -0.48 | -0.50 |
| RAPGEF4 | -0.45 | -0.47 |
| PLA2G4A | -0.45 | -0.49 |
| CHN1 | -0.44 | -0.46 |
| ITM2B | -0.44 | -0.47 |
| AF347015.31 | -0.43 | -0.47 |
| TPMT | -0.43 | -0.43 |
| ACOT13 | -0.43 | -0.48 |
| SERPINI1 | -0.43 | -0.43 |
| CARD16 | -0.42 | -0.51 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME NEURONAL SYSTEM | 279 | 221 | All SZGR 2.0 genes in this pathway |
| REACTOME VOLTAGE GATED POTASSIUM CHANNELS | 43 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME POTASSIUM CHANNELS | 98 | 68 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING UP | 108 | 69 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 | 491 | 319 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 HCP WITH H3K27ME3 | 435 | 318 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP C | 92 | 60 | All SZGR 2.0 genes in this pathway |
| ZWANG DOWN BY 2ND EGF PULSE | 293 | 119 | All SZGR 2.0 genes in this pathway |