Gene Page: HGS

Summary ?
GeneID9146
SymbolHGS
SynonymsHRS
Descriptionhepatocyte growth factor-regulated tyrosine kinase substrate
ReferenceMIM:604375|HGNC:HGNC:4897|Ensembl:ENSG00000185359|HPRD:05085|Vega:OTTHUMG00000178109
Gene typeprotein-coding
Map location17q25
Pascal p-value0.206
Sherlock p-value0.55
Fetal beta-0.442
eGeneMyers' cis & trans
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0198 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1578978chr8118196802HGS91460.06trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BYSL0.920.92
PSMD30.920.92
DGCR140.920.91
USF10.920.94
HINFP0.920.92
KAT50.920.93
DAXX0.920.93
PRPF310.910.90
PUF600.910.91
DHPS0.910.93
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.83-0.89
AF347015.31-0.83-0.87
MT-CO2-0.83-0.86
AF347015.8-0.82-0.88
MT-CYB-0.82-0.87
AF347015.33-0.81-0.85
AF347015.15-0.80-0.86
AF347015.2-0.78-0.86
AF347015.21-0.77-0.87
AF347015.26-0.76-0.86

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008270zinc ion bindingIEA-
GO:0019904protein domain specific bindingIPI11984006 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS9407053 
GO:0008285negative regulation of cell proliferationTAS9407053 
GO:0006886intracellular protein transportIEA-
GO:0016197endosome transportNAS10861283 
GO:0042176regulation of protein catabolic processTAS15611048 
GO:0046426negative regulation of JAK-STAT cascadeIDA12444102 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP10567358 |12218189 |15962011 
GO:0005737cytoplasmIEA-
GO:0016020membraneIEA-
GO:0031901early endosome membraneIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BEGAINKIAA1446brain-enriched guanylate kinase-associated homolog (rat)Two-hybridBioGRID16189514 
C1orf190FLJ25163chromosome 1 open reading frame 190Two-hybridBioGRID16189514 
CCDC33FLJ23168 | FLJ32855 | MGC34145coiled-coil domain containing 33Two-hybridBioGRID16189514 
CLTCCHC | CHC17 | CLH-17 | CLTCL2 | Hc | KIAA0034clathrin, heavy chain (Hc)-HPRD,BioGRID11532964 
DAZAP2KIAA0058 | MGC14319 | MGC766 | PRTBDAZ associated protein 2Two-hybridBioGRID16189514 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID12151521 
EHMT2BAT8 | C6orf30 | DKFZp686H08213 | FLJ35547 | G9A | KMT1C | NG36 | NG36/G9aeuchromatic histone-lysine N-methyltransferase 2Two-hybridBioGRID16189514 
EPS15AF-1P | AF1P | MLLT5epidermal growth factor receptor pathway substrate 15-HPRD,BioGRID12551915 
EXOC72-5-3p | DKFZp686J04253 | EX070 | EXO70 | EXOC1 | Exo70p | FLJ40965 | FLJ46415 | YJL085Wexocyst complex component 7Two-hybridBioGRID16189514 
EXOC8EXO84 | Exo84p | SEC84exocyst complex component 8Two-hybridBioGRID16189514 
GKAP1FKSG21 | FLJ25469 | GKAP42G kinase anchoring protein 1Two-hybridBioGRID16189514 
HAP1HAP2 | HIP5 | HLP | hHLP1huntingtin-associated protein 1-HPRD,BioGRID12021262 
KRT18CYK18 | K18keratin 18Two-hybridBioGRID16189514 
KRT19CK19 | K19 | K1CS | MGC15366keratin 19Two-hybridBioGRID16189514 
LDOC1BCUR1 | Mar7 | Mart7leucine zipper, down-regulated in cancer 1Two-hybridBioGRID16189514 
LYSTCHS | CHS1lysosomal trafficking regulator-HPRD,BioGRID11984006 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7-HPRD,BioGRID11397816 
MED7CRSP33 | CRSP9 | MGC12284mediator complex subunit 7Two-hybridBioGRID16189514 
METAUTS9 | HGFR | RCCP2 | c-Metmet proto-oncogene (hepatocyte growth factor receptor)-HPRD8380735 
MIF4GDAD023 | MGC45027 | MIFD | SLIP1MIF4G domain containingTwo-hybridBioGRID16189514 
NEDD4KIAA0093 | MGC176705 | NEDD4-1 | RPF1neural precursor cell expressed, developmentally down-regulated 4-HPRD,BioGRID12230472 
NF2ACN | BANF | SCHneurofibromin 2 (merlin)-HPRD,BioGRID10861283 |11285248 
NF2ACN | BANF | SCHneurofibromin 2 (merlin)merlin interacts with HRS.BIND12444101 
NMI-N-myc (and STAT) interactorTwo-hybridBioGRID16189514 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1-HPRD,BioGRID11397816 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD10970851 
SNAP25FLJ23079 | RIC-4 | RIC4 | SEC9 | SNAP | SNAP-25 | bA416N4.2 | dJ1068F16.2synaptosomal-associated protein, 25kDa-HPRD10825299 |11493665|11493665 
SNAP25FLJ23079 | RIC-4 | RIC4 | SEC9 | SNAP | SNAP-25 | bA416N4.2 | dJ1068F16.2synaptosomal-associated protein, 25kDa-HPRD11493665 
SNX1HsT17379 | MGC8664 | SNX1A | Vps5sorting nexin 1-HPRD,BioGRID11110793 
STAMDKFZp686J2352 | STAM1signal transducing adaptor molecule (SH3 domain and ITAM motif) 1-HPRD,BioGRID9407053 
STAM2DKFZp564C047 | Hbp | STAM2A | STAM2Bsignal transducing adaptor molecule (SH3 domain and ITAM motif) 2Affinity Capture-Western
Co-fractionation
Two-hybrid		BioGRID12551915 |16189514 
TADA2LADA2 | ADA2A | FLJ12705 | KL04P | hADA2transcriptional adaptor 2 (ADA2 homolog, yeast)-likeTwo-hybridBioGRID16189514 
TSG101TSG10 | VPS23tumor susceptibility gene 101TSG101 interacts with HGS (Hrs).BIND14519844 
TSG101TSG10 | VPS23tumor susceptibility gene 101Affinity Capture-Western
Two-hybrid		BioGRID12802020 |16189514 
TSG101TSG10 | VPS23tumor susceptibility gene 101HRS interacts with TSG101.BIND12802020 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Two-hybridBioGRID16189514 
UBQLN1DA41 | DSK2 | FLJ90054 | PLIC-1 | XDRP1ubiquilin 1Two-hybridBioGRID16189514 
USHBP1AIEBP | FLJ38709 | FLJ90681 | MCC2Usher syndrome 1C binding protein 1Two-hybridBioGRID16189514 
VPS37AFLJ32642 | FLJ42616 | HCRP1 | PQBP2vacuolar protein sorting 37 homolog A (S. cerevisiae)-HPRD15240819 |15509564 
VPS37CFLJ20847vacuolar protein sorting 37 homolog C (S. cerevisiae)-HPRD,BioGRID15509564 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
PID MET PATHWAY 8060All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 10278All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY 4838All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY 4135All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 6957All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING 12974All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER 10980All SZGR 2.0 genes in this pathway
REACTOME EGFR DOWNREGULATION 2514All SZGR 2.0 genes in this pathway
REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT 2715All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276187All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293179All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC 10874All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514330All SZGR 2.0 genes in this pathway
TAGHAVI NEOPLASTIC TRANSFORMATION 1210All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175125All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP 188121All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP 14094All SZGR 2.0 genes in this pathway