Gene Page: CD3G

Summary ?
GeneID917
SymbolCD3G
SynonymsCD3-GAMMA|IMD17|T3G
DescriptionCD3g molecule
ReferenceMIM:186740|HGNC:HGNC:1675|HPRD:07037|
Gene typeprotein-coding
Map location11q23
Pascal p-value0.012

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.006 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004888transmembrane receptor activityIMP12794121 
GO:0030159receptor signaling complex scaffold activityNAS12794121 
GO:0042608T cell receptor bindingNAS11186279 
GO:0046982protein heterodimerization activityIPI9485181 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006461protein complex assemblyNAS12794121 
GO:0007166cell surface receptor linked signal transductionIMP12407027 
GO:0007163establishment or maintenance of cell polarityIMP12407027 
GO:0042981regulation of apoptosisIMP12407027 
GO:0015031protein transportIMP12794121 
GO:0042110T cell activationNAS12407027 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042101T cell receptor complexNASSynap (GO term level: 8)9485181 
GO:0005886plasma membraneEXP11048639 |11827988 |15489916 
|17652306 
GO:0005887integral to plasma membraneNAS9485181 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG HEMATOPOIETIC CELL LINEAGE 8860All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
BIOCARTA CSK PATHWAY 2420All SZGR 2.0 genes in this pathway
BIOCARTA CTL PATHWAY 1511All SZGR 2.0 genes in this pathway
BIOCARTA TCAPOPTOSIS PATHWAY 118All SZGR 2.0 genes in this pathway
BIOCARTA IL17 PATHWAY 1712All SZGR 2.0 genes in this pathway
BIOCARTA IL12 PATHWAY 2317All SZGR 2.0 genes in this pathway
BIOCARTA TCRA PATHWAY 1310All SZGR 2.0 genes in this pathway
BIOCARTA NO2IL12 PATHWAY 1714All SZGR 2.0 genes in this pathway
BIOCARTA TOB1 PATHWAY 2114All SZGR 2.0 genes in this pathway
BIOCARTA STATHMIN PATHWAY 1917All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY 4937All SZGR 2.0 genes in this pathway
BIOCARTA TCYTOTOXIC PATHWAY 1411All SZGR 2.0 genes in this pathway
BIOCARTA THELPER PATHWAY 1411All SZGR 2.0 genes in this pathway
BIOCARTA CTLA4 PATHWAY 2118All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 6651All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 6354All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 5342All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 10278All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 6556All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY 3329All SZGR 2.0 genes in this pathway
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 7037All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING 5446All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM TCR SIGNALING 3732All SZGR 2.0 genes in this pathway
REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 1615All SZGR 2.0 genes in this pathway
REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE 1414All SZGR 2.0 genes in this pathway
REACTOME GENERATION OF SECOND MESSENGER MOLECULES 2725All SZGR 2.0 genes in this pathway
REACTOME PD1 SIGNALING 1814All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 6348All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
AKL HTLV1 INFECTION DN 6841All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 9071All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 9268All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL DN 12775All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259185All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252155All SZGR 2.0 genes in this pathway
VILIMAS NOTCH1 TARGETS UP 5241All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200115All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 2 DN 98All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 5 DN 5031All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 DN 3819All SZGR 2.0 genes in this pathway