Summary ?
GeneID919
SymbolCD247
SynonymsCD3-ZETA|CD3H|CD3Q|CD3Z|IMD25|T3Z|TCRZ
DescriptionCD247 molecule
ReferenceMIM:186780|HGNC:HGNC:1677|Ensembl:ENSG00000198821|HPRD:01729|Vega:OTTHUMG00000034593
Gene typeprotein-coding
Map location1q24.2
Sherlock p-value0.696
Fetal beta-0.317
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg095544431167487762CD2470.004-4.422DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs13375406chr195606304CD2479190.13trans
rs16838771chr1157511227CD2479197.906E-5trans
rs16856639chr1166116296CD2479190.15trans
rs973381chr1166121317CD2479190.15trans
rs1538755chr1210893874CD2479190.13trans
rs825935chr24808721CD2479190.19trans
rs825932chr24811625CD2479190.07trans
rs16865228chr26629622CD2479190.1trans
rs16865230chr26630187CD2479190.1trans
rs11691188chr26631799CD2479190.1trans
rs3755119chr253957339CD2479190.05trans
rs17045286chr254049393CD2479193.687E-4trans
rs10202944chr272257857CD2479190.15trans
rs7602648chr2104661176CD2479190.03trans
rs6708612chr2148165722CD2479190.17trans
rs6729020chr2189064719CD2479190.13trans
snp_a-21861470CD2479190.02trans
rs6803351chr317336986CD2479190trans
rs11916205chr317392363CD2479190trans
rs17043486chr317399005CD2479190trans
rs17029249chr317416384CD2479190trans
rs10510474chr317417495CD2479190trans
rs17043623chr317478890CD2479190trans
rs11128830chr317481727CD2479190trans
rs43789480CD2479190.12trans
rs11927611chr317848434CD2479190trans
rs6793958chr317853055CD2479192.217E-10trans
rs17044072chr317854496CD2479190.01trans
rs17044097chr317889750CD2479190trans
rs17044102chr317889838CD2479190.03trans
rs4591529chr332330610CD2479190.15trans
rs76267820CD2479190.03trans
rs2600956chr3132624112CD2479190.12trans
rs1452144chr3132627627CD2479190.12trans
rs7635430chr3180152035CD2479190.11trans
rs12912590CD2479190trans
rs17005625chr4141141923CD2479190.09trans
rs17005641chr4141152656CD2479190.04trans
rs10026641chr4183431866CD2479190trans
rs11723043chr4189507117CD2479190.04trans
rs4702089chr515640330CD2479190.08trans
rs4702104chr515746397CD2479190.01trans
rs17138463chr5115286058CD2479190.07trans
rs17138468chr5115288423CD2479190.05trans
rs10519531chr5117332352CD2479192.702E-10trans
rs6867333chr5117339065CD2479190.05trans
rs17736846chr5169133824CD2479190.02trans
rs9503329chr62894607CD2479190trans
rs17458000chr6151384414CD2479190trans
rs1321606chr6153545278CD2479190.17trans
rs163007chr6155726495CD2479190.15trans
rs7760005chr6156850663CD2479190.02trans
rs11983989chr746351006CD2479190.09trans
rs17172680chr746362331CD2479190.09trans
rs17172688chr746396563CD2479190.09trans
rs11978272chr780119689CD2479190.2trans
rs17163613chr790764256CD2479196.475E-5trans
rs17684427chr7122482976CD2479190.15trans
rs7796458chr7154873701CD2479190.13trans
rs1474448chr816353122CD2479190.09trans
rs4737205chr865995897CD2479190.19trans
rs174953710CD2479190trans
rs17495754chr882152549CD2479190.08trans
rs7813477chr885144311CD2479190.06trans
rs4878586chr927810413CD2479190.05trans
rs1410577chr990283060CD2479190.18trans
rs4742740chr9101524552CD2479190.07trans
rs4743277chr9101557528CD2479190.06trans
rs11252838chr104972173CD2479190.01trans
rs16933426chr1078113005CD2479192.036E-5trans
rs16933436chr1078118247CD2479190.18trans
rs16933437chr1078118689CD2479190.18trans
rs16933467chr1078141332CD2479190.18trans
rs10885916chr10118118819CD2479190.04trans
rs11199540chr10122530843CD2479190.02trans
rs2459087chr10123821264CD2479190.01trans
rs11016704chr10128989145CD2479190.17trans
rs64864180CD2479193.568E-4trans
rs12292520chr1148086150CD2479190.05trans
rs17789481chr1148110042CD2479190.2trans
rs11220020chr11125183479CD2479190.09trans
rs10878919chr1269521979CD2479195.246E-4trans
rs7136572chr1295959787CD2479196.866E-9trans
rs935031chr1296861369CD2479190.12trans
rs10848152chr12131062467CD2479190trans
rs11061005chr12131063527CD2479190trans
rs7989474chr1329113187CD2479190.16trans
rs1335797chr1364425435CD2479191.019E-5trans
rs17115591chr1445262026CD2479190.13trans
rs12588364chr1479411335CD2479190.12trans
rs11159388chr1479417713CD2479190.12trans
rs11159390chr1479424474CD2479190.12trans
rs10147554chr1489902966CD2479190.13trans
rs11623367chr1489924832CD2479190trans
rs8026736chr1545364871CD2479190.14trans
rs10518880chr1570491974CD2479190.02trans
rs7180781chr1578455354CD2479190.13trans
rs17135416chr161645744CD2479190.17trans
rs4780835chr1619985287CD2479190.12trans
rs7198149chr1657920460CD2479190.03trans
rs7197514chr1665652629CD2479190.01trans
rs16944062chr1676272616CD2479190.01trans
rs16942128chr1745764234CD2479190.15trans
rs12968895chr1819650706CD2479190.13trans
rs9304469chr1822169423CD2479190.06trans
rs17187821chr1822209158CD2479190.05trans
rs17785402chr205173471CD2479190.06trans
rs2830443chr2128109967CD2479190.16trans
rs6586271chr2144362641CD2479190.03trans
rs12627758chr2229382830CD2479190.03trans
rs16989337chr2232025054CD2479190.13trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SECTM10.640.27
C19orf350.630.43
KISS1R0.620.21
PTGER10.570.42
SMOC20.560.54
AC011500.20.540.31
C1orf1330.540.39
P2RY10.540.27
RXRG0.520.33
FAM40B0.510.36
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C18orf8-0.44-0.58
GTDC1-0.43-0.47
GARNL3-0.42-0.52
CABYR-0.41-0.58
ZNF30-0.40-0.56
CBARA1-0.40-0.53
SFXN3-0.40-0.51
DYNC1I1-0.39-0.48
RNF8-0.39-0.51
RAD51C-0.39-0.42

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004888transmembrane receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0042803protein homodimerization activityNAS12110186 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007166cell surface receptor linked signal transductionIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042101T cell receptor complexIDASynap (GO term level: 8)8176201 
GO:0005737cytoplasmIDA11390434 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneEXP11048639 |11827988 |15489916 
|17652306 
GO:0005886plasma membraneIDA1390434 |11390434 
GO:0042105alpha-beta T cell receptor complexIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATXN2ATX2 | FLJ46772 | SCA2 | TNRC13ataxin 2Affinity Capture-WesternBioGRID9575182 
CD2SRBC | T11CD2 molecule-HPRD8977276 
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD2845582 
CD28MGC138290 | Tp44CD28 molecule-HPRD8760790 
CD3DCD3-DELTA | T3DCD3d molecule, delta (CD3-TCR complex)-HPRD9485181 
CD3EFLJ18683 | T3E | TCRECD3e molecule, epsilon (CD3-TCR complex)-HPRD9485181 
CD5LEU1 | T1CD5 molecule-HPRD1385158 
CSKMGC117393c-src tyrosine kinase-HPRD9172452 
DOCK2FLJ46592 | KIAA0209dedicator of cytokinesis 2-HPRD,BioGRID12176041 
GAB2KIAA0571GRB2-associated binding protein 2-HPRD,BioGRID11572860 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)-HPRD,BioGRID11349123 
LY6ERIG-E | RIGE | SCA-2 | SCA2 | TSA-1lymphocyte antigen 6 complex, locus E-HPRD9575182 
NCR1CD335 | LY94 | NK-p46 | NKP46natural cytotoxicity triggering receptor 1-HPRD,BioGRID9625766 
NCR31C7 | CD337 | LY117 | MALS | NKp30natural cytotoxicity triggering receptor 3-HPRD12731048 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, C-HPRD,BioGRID7526385 
SH2B3CELIAC13 | LNKSH2B adaptor protein 3-HPRD10799879 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD8656061 
SLASLA1 | SLAPSrc-like-adaptor-HPRD,BioGRID10449770 
SLA2C20orf156 | FLJ21992 | MGC49845 | SLAP-2 | SLAP2Src-like-adaptor 2-HPRD,BioGRID11891219 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID9880255 
STAT5BSTAT5signal transducer and activator of transcription 5B-HPRD,BioGRID9880255 
TFRCCD71 | TFR | TFR1 | TRFRtransferrin receptor (p90, CD71)-HPRD9448136 
TIRAPFLJ42305 | Mal | wyatttoll-interleukin 1 receptor (TIR) domain containing adaptor protein-HPRD11572860 
TRA@FLJ22602 | MGC117436 | MGC22624 | MGC23964 | MGC71411 | TCRA | TCRD | TRAT cell receptor alpha locus-HPRD2138083 
TRAT1HSPC062 | TCRIM | TRIMT cell receptor associated transmembrane adaptor 1-HPRD9687533 |11390434 
TRAT1HSPC062 | TCRIM | TRIMT cell receptor associated transmembrane adaptor 1-HPRD,BioGRID11390434 
UNC119HRG4unc-119 homolog (C. elegans)-HPRD,BioGRID14757743 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDa-HPRD8366117 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 13792All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
BIOCARTA CSK PATHWAY 2420All SZGR 2.0 genes in this pathway
BIOCARTA CTL PATHWAY 1511All SZGR 2.0 genes in this pathway
BIOCARTA TCAPOPTOSIS PATHWAY 118All SZGR 2.0 genes in this pathway
BIOCARTA IL17 PATHWAY 1712All SZGR 2.0 genes in this pathway
BIOCARTA IL12 PATHWAY 2317All SZGR 2.0 genes in this pathway
BIOCARTA TCRA PATHWAY 1310All SZGR 2.0 genes in this pathway
BIOCARTA NO2IL12 PATHWAY 1714All SZGR 2.0 genes in this pathway
BIOCARTA TOB1 PATHWAY 2114All SZGR 2.0 genes in this pathway
BIOCARTA STATHMIN PATHWAY 1917All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY 4937All SZGR 2.0 genes in this pathway
BIOCARTA TCYTOTOXIC PATHWAY 1411All SZGR 2.0 genes in this pathway
BIOCARTA THELPER PATHWAY 1411All SZGR 2.0 genes in this pathway
BIOCARTA CTLA4 PATHWAY 2118All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 6651All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 6354All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 5342All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 10278All SZGR 2.0 genes in this pathway
PID HIV NEF PATHWAY 3526All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 6556All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY 3329All SZGR 2.0 genes in this pathway
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL 7037All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING 5446All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM TCR SIGNALING 3732All SZGR 2.0 genes in this pathway
REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS 1615All SZGR 2.0 genes in this pathway
REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE 1414All SZGR 2.0 genes in this pathway
REACTOME GENERATION OF SECOND MESSENGER MOLECULES 2725All SZGR 2.0 genes in this pathway
REACTOME PD1 SIGNALING 1814All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 6348All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 13281All SZGR 2.0 genes in this pathway
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 2819All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
MOREIRA RESPONSE TO TSA DN 1816All SZGR 2.0 genes in this pathway
SCHLINGEMANN SKIN CARCINOGENESIS TPA DN 2915All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202115All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200115All SZGR 2.0 genes in this pathway
FINAK BREAST CANCER SDPP SIGNATURE 2611All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
SENGUPTA EBNA1 ANTICORRELATED 17385All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194133All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 10772All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-214410416m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG