Gene Page: CD5

Summary ?
GeneID921
SymbolCD5
SynonymsLEU1|T1
DescriptionCD5 molecule
ReferenceMIM:153340|HGNC:HGNC:1685|Ensembl:ENSG00000110448|HPRD:01078|Vega:OTTHUMG00000167825
Gene typeprotein-coding
Map location11q13
Pascal p-value0.464
Fetal beta-0.062
DMG1 (# studies)
eGeneCerebellar Hemisphere
Cerebellum
Cortex

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0226 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg246747031160869960CD51.44E-5-4.592DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PODNL10.740.23
KLK100.710.21
EGFL60.670.15
GPR1770.660.04
MAP4K10.660.19
ANXA30.660.36
OTX20.660.11
HSD11B20.660.23
ANO20.650.10
CEACAM210.640.20
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GTDC1-0.31-0.35
EMX1-0.30-0.38
SATB1-0.28-0.36
ARL4D-0.28-0.34
ARHGEF2-0.27-0.32
C1orf96-0.27-0.33
CRYM-0.27-0.32
ZNF238-0.27-0.35
MEF2C-0.26-0.34
LMO7-0.26-0.33

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005044scavenger receptor activityIEA-
GO:0005515protein bindingIPI1711157 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008283cell proliferationNAS3093892 
GO:0008037cell recognitionNAS1711157 
GO:0008624induction of apoptosis by extracellular signalsIEA-
GO:0031295T cell costimulationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0009897external side of plasma membraneIEA-
GO:0005886plasma membraneIDA11390434 
GO:0005887integral to plasma membraneNAS1711157 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAMK2DCAMKD | DKFZp686G23119 | DKFZp686I2288 | MGC44911calcium/calmodulin-dependent protein kinase II deltain vitro
Two-hybrid		BioGRID9692886 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD,BioGRID9603468 
CD2SRBC | T11CD2 molecule-HPRD,BioGRID10510361 
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD1385158 
CD27MGC20393 | S152 | T14 | TNFRSF7 | Tp55CD27 moleculeReconstituted ComplexBioGRID1711157 
CD4CD4mutCD4 molecule-HPRD7539755 
CD6FLJ44171 | TP120CD6 molecule-HPRD,BioGRID12473675 
CD72CD72b | LYB2CD72 molecule-HPRD1711157 |8806810 
DYNLT3RP3 | TCTE1L | TCTEX1Ldynein, light chain, Tctex-type 3-HPRD,BioGRID9692886 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD7513045 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD,BioGRID9079809 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD,BioGRID10082557 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD,BioGRID9603468 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDa-HPRD,BioGRID9378960 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG HEMATOPOIETIC CELL LINEAGE 8860All SZGR 2.0 genes in this pathway
BIOCARTA DC PATHWAY 2220All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276187All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN UP 184125All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
SHANK TAL1 TARGETS DN 106All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON 15893All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 30MIN 5436All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 9268All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 11462All SZGR 2.0 genes in this pathway