Gene Page: KLF4

Summary ?
GeneID9314
SymbolKLF4
SynonymsEZF|GKLF
DescriptionKruppel-like factor 4 (gut)
ReferenceMIM:602253|HGNC:HGNC:6348|Ensembl:ENSG00000136826|Vega:OTTHUMG00000020449
Gene typeprotein-coding
Map location9q31
Pascal p-value0.045
Sherlock p-value0.822
Fetal beta0.023
eGeneMyers' cis & trans
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1339760chr9110750458KLF493140.19cis
rs10218671chr1158362552KLF493140.11trans
rs17006539chr1219926844KLF493140.15trans
rs6712107chr214178653KLF493140.04trans
rs16861129chr214201738KLF493140.04trans
rs16861131chr214202085KLF493140.04trans
rs7589712chr214205064KLF493140.12trans
rs1038697chr218537074KLF493140.01trans
rs6718379chr218632808KLF493140.08trans
rs17535450chr239900012KLF493140.04trans
rs17038084chr285192280KLF493140.15trans
rs17498115chr285249294KLF493140.02trans
rs17616012chr2167926783KLF493140.03trans
rs17616252chr2167976691KLF493140.04trans
rs1691463chr384914366KLF493142.156E-4trans
rs394185chr384959076KLF493140trans
rs9873752chr385401647KLF493140.16trans
rs9288980chr3112964991KLF493142.866E-5trans
rs1499898chr3112974550KLF493140.15trans
rs3995908chr3112998529KLF493142.866E-5trans
rs7652801chr3113008605KLF493142.866E-5trans
rs7625829chr3113103743KLF493145.127E-4trans
rs4419353chr3113254936KLF493140trans
rs9813633chr3113908225KLF493140.13trans
rs2922180chr3125280472KLF493140.01trans
rs2976809chr3125451738KLF493140.02trans
rs9917710chr3176280218KLF493141.132E-6trans
rs16854290chr442384014KLF493140.04trans
rs16854296chr442384362KLF493140.04trans
rs4241605chr478161505KLF493140.02trans
rs4241606chr478161919KLF493140.05trans
rs313946chr4113975904KLF493140.14trans
rs16894149chr561013724KLF493146.594E-4trans
rs6449550chr561034312KLF493146.656E-4trans
rs17056435chr5158453782KLF493140trans
rs9313797chr5158465457KLF493140.19trans
rs17056474chr5158468105KLF493140.19trans
rs2294262chr616108966KLF493140.19trans
rs16883859chr620474617KLF493140.11trans
rs16883862chr620474766KLF493140.11trans
rs12528414chr638404800KLF493140.1trans
rs6939897chr667913123KLF493140.12trans
rs6455226chr667930295KLF493140.06trans
rs16868852chr670980333KLF493140.05trans
rs2064428chr685067126KLF493141.696E-4trans
rs9489379chr6118739603KLF493140.16trans
rs6903632chr6118783045KLF493140.16trans
rs12207554chr6118860704KLF493140.16trans
rs9489468chr6118935681KLF493140.04trans
rs7800937chr7143093306KLF493140.15trans
rs2199402chr89201002KLF493147.47E-4trans
rs2169384chr89216985KLF493147.642E-4trans
rs1381350chr89217194KLF493142.163E-4trans
rs7841407chr89243427KLF493143.308E-5trans
rs2739726chr817998576KLF493140.06trans
rs2954041chr832522625KLF493140.1trans
rs2976526chr832574650KLF493140.1trans
rs2975504chr832578998KLF493140.1trans
rs7045470chr911756233KLF493140.14trans
rs7850851chr937928770KLF493140.04trans
rs998410chr9117622673KLF493140.06trans
rs9423711chr102574802KLF493140.02trans
rs748375chr1033440178KLF493140trans
rs7081666chr1047673800KLF493140.16trans
rs11199997chr1085456823KLF493140.05trans
rs11820030chr1176133564KLF493140.02trans
rs17134872chr1176139845KLF493140.02trans
rs107512550KLF493140.07trans
rs11236774chr1176234952KLF493140.02trans
rs2305164chr12365649KLF493140.1trans
rs4149623chr126450577KLF493140.01trans
rs2856339chr1211906818KLF493140.12trans
rs107479720KLF493140.16trans
rs11112163chr12105072508KLF493140.04trans
rs17080889chr1320939135KLF493140.07trans
rs7995192chr1350782598KLF493140.02trans
rs9529974chr1372821935KLF493140.08trans
rs11840833chr1394378306KLF493140.07trans
rs10142086chr1435135892KLF493140.03trans
rs10149864chr1486719683KLF493140.14trans
rs2093759chr1497171024KLF493140.01trans
rs17244419chr1497171074KLF493143.175E-4trans
rs4147419chr1535030570KLF493140.09trans
rs2249982chr1570236349KLF493140.08trans
rs939043chr1570236428KLF493140.01trans
rs13380712chr1625601181KLF493140.18trans
rs17294918chr1652717122KLF493140.03trans
rs16940550chr1813442256KLF493140.07trans
rs9949772chr1831042632KLF493140.03trans
rs4987765chr1860905021KLF493140.04trans
rs11873703chr1861448702KLF493148.902E-4trans
rs6017989chr2045329846KLF493140.15trans
rs6095741chr2048666589KLF493140.01trans
rs369613chr2222380717KLF493140.04trans
rs410285chr2222381767KLF493140.04trans
rs9627184chr2248284887KLF493140.12trans
rs5768143chr2248307043KLF493140.12trans
rs5768165chr2248318197KLF493141.499E-6trans
rs5768168chr2248319334KLF493141.499E-6trans
rs5768173chr2248321475KLF493141.499E-6trans
rs1883665chrX17650382KLF493140.04trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NPAT0.920.93
ZRANB10.920.94
NUP1530.920.94
MORC30.920.93
ZZZ30.920.93
CKAP50.920.93
N4BP10.910.94
KIAA09470.910.94
CTR90.910.92
CUL4A0.910.92
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.76-0.83
FXYD1-0.76-0.83
MT-CO2-0.76-0.82
IFI27-0.75-0.82
HIGD1B-0.74-0.83
AF347015.33-0.72-0.78
AF347015.21-0.72-0.84
AF347015.8-0.71-0.81
AF347015.27-0.71-0.77
MT-CYB-0.71-0.78

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID BETA CATENIN NUC PATHWAY 8060All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN 1611All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7253All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN 13686All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391222All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 9065All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255177All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 11679All SZGR 2.0 genes in this pathway
CASORELLI APL SECONDARY VS DE NOVO UP 3925All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368234All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306188All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258141All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS YELLOW UP 3225All SZGR 2.0 genes in this pathway
BILBAN B CLL LPL DN 4225All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN 240171All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 UP 6446All SZGR 2.0 genes in this pathway
LIU CDX2 TARGETS UP 3622All SZGR 2.0 genes in this pathway
LANDIS BREAST CANCER PROGRESSION DN 7043All SZGR 2.0 genes in this pathway
GESERICK TERT TARGETS DN 2116All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153100All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP 11578All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID DN 6745All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 65 DN 3722All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 DN 14993All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 12792All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392251All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
MATTIOLI MULTIPLE MYELOMA WITH 14Q32 TRANSLOCATIONS 3625All SZGR 2.0 genes in this pathway
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP 7347All SZGR 2.0 genes in this pathway
YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 DN 8748All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149101All SZGR 2.0 genes in this pathway
HOWLIN PUBERTAL MAMMARY GLAND 6940All SZGR 2.0 genes in this pathway
SCHLESINGER METHYLATED DE NOVO IN CANCER 8864All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156106All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN 11078All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A UP 142104All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP 12779All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206136All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 120 MCF10A 6544All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256159All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN UP 8661All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 VS CD2 UP 6647All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 13Q14 DELETION 2418All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 DN 7748All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 12690All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS DN 8667All SZGR 2.0 genes in this pathway
MENSE HYPOXIA UP 9871All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
GEORGANTAS HSC MARKERS 7147All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 2HR 5136All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK 7547All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 7757All SZGR 2.0 genes in this pathway
GEISS RESPONSE TO DSRNA UP 3829All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 9 9259All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220147All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353226All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 12081All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439257All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 10868All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 UP 11169All SZGR 2.0 genes in this pathway
CONRAD STEM CELL 3927All SZGR 2.0 genes in this pathway
WU SILENCED BY METHYLATION IN BLADDER CANCER 5542All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP 221150All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293203All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS UP 10878All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
SCHOEN NFKB SIGNALING 3426All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA DN 6845All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA UP 6638All SZGR 2.0 genes in this pathway
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN 3726All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306191All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5 3022All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430288All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS UP 11265All SZGR 2.0 genes in this pathway
DURAND STROMA NS UP 162103All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222159All SZGR 2.0 genes in this pathway