Gene Page: CCDC114
Summary ?
| GeneID | 93233 |
| Symbol | CCDC114 |
| Synonyms | CILD20 |
| Description | coiled-coil domain containing 114 |
| Reference | MIM:615038|HGNC:HGNC:26560|Ensembl:ENSG00000105479|HPRD:08149|Vega:OTTHUMG00000156161 |
| Gene type | protein-coding |
| Map location | 19q13.33 |
| Pascal p-value | 0.134 |
| Fetal beta | 0.404 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Cerebellar Hemisphere Cerebellum Cortex Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg23877608 | 19 | 48823413 | CCDC114 | 5.749E-4 | -0.607 | 0.049 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs60056362 | 19 | 48793950 | CCDC114 | ENSG00000105479.11 | 1.242E-6 | 0.01 | 30118 | gtex_brain_ba24 |
| rs10406217 | 19 | 48799027 | CCDC114 | ENSG00000105479.11 | 7.001E-7 | 0.01 | 25041 | gtex_brain_ba24 |
| rs4572515 | 19 | 48799605 | CCDC114 | ENSG00000105479.11 | 6.92E-7 | 0.01 | 24463 | gtex_brain_ba24 |
| rs2292113 | 19 | 48800791 | CCDC114 | ENSG00000105479.11 | 6.908E-7 | 0.01 | 23277 | gtex_brain_ba24 |
| rs7258665 | 19 | 48803482 | CCDC114 | ENSG00000105479.11 | 6.904E-7 | 0.01 | 20586 | gtex_brain_ba24 |
| rs10416232 | 19 | 48808851 | CCDC114 | ENSG00000105479.11 | 6.904E-7 | 0.01 | 15217 | gtex_brain_ba24 |
| rs249368 | 19 | 48817195 | CCDC114 | ENSG00000105479.11 | 6.904E-7 | 0.01 | 6873 | gtex_brain_ba24 |
| rs249372 | 19 | 48818072 | CCDC114 | ENSG00000105479.11 | 6.911E-7 | 0.01 | 5996 | gtex_brain_ba24 |
| rs249374 | 19 | 48819659 | CCDC114 | ENSG00000105479.11 | 6.904E-7 | 0.01 | 4409 | gtex_brain_ba24 |
| rs249376 | 19 | 48820447 | CCDC114 | ENSG00000105479.11 | 6.904E-7 | 0.01 | 3621 | gtex_brain_ba24 |
| rs249378 | 19 | 48821345 | CCDC114 | ENSG00000105479.11 | 6.904E-7 | 0.01 | 2723 | gtex_brain_ba24 |
| rs156674 | 19 | 48822529 | CCDC114 | ENSG00000105479.11 | 6.904E-7 | 0.01 | 1539 | gtex_brain_ba24 |
| rs275579 | 19 | 48847798 | CCDC114 | ENSG00000105479.11 | 1.219E-6 | 0.01 | -23730 | gtex_brain_ba24 |
| rs275584 | 19 | 48850913 | CCDC114 | ENSG00000105479.11 | 5.96E-7 | 0.01 | -26845 | gtex_brain_ba24 |
| rs579466 | 19 | 48852193 | CCDC114 | ENSG00000105479.11 | 5.609E-7 | 0.01 | -28125 | gtex_brain_ba24 |
| rs437358 | 19 | 48860702 | CCDC114 | ENSG00000105479.11 | 6.076E-7 | 0.01 | -36634 | gtex_brain_ba24 |
| rs438767 | 19 | 48863386 | CCDC114 | ENSG00000105479.11 | 2.235E-7 | 0.01 | -39318 | gtex_brain_ba24 |
| rs115202326 | 19 | 48793540 | CCDC114 | ENSG00000105479.11 | 1.278E-7 | 0.01 | 30528 | gtex_brain_putamen_basal |
| rs2380123 | 19 | 48793690 | CCDC114 | ENSG00000105479.11 | 6.518E-7 | 0.01 | 30378 | gtex_brain_putamen_basal |
| rs60056362 | 19 | 48793950 | CCDC114 | ENSG00000105479.11 | 1.591E-7 | 0.01 | 30118 | gtex_brain_putamen_basal |
| rs6509374 | 19 | 48794174 | CCDC114 | ENSG00000105479.11 | 6.548E-7 | 0.01 | 29894 | gtex_brain_putamen_basal |
| rs10403865 | 19 | 48795541 | CCDC114 | ENSG00000105479.11 | 1.02E-6 | 0.01 | 28527 | gtex_brain_putamen_basal |
| rs1963834 | 19 | 48796641 | CCDC114 | ENSG00000105479.11 | 1.127E-6 | 0.01 | 27427 | gtex_brain_putamen_basal |
| rs10406217 | 19 | 48799027 | CCDC114 | ENSG00000105479.11 | 1.172E-7 | 0.01 | 25041 | gtex_brain_putamen_basal |
| rs4572515 | 19 | 48799605 | CCDC114 | ENSG00000105479.11 | 1.167E-7 | 0.01 | 24463 | gtex_brain_putamen_basal |
| rs2292113 | 19 | 48800791 | CCDC114 | ENSG00000105479.11 | 1.247E-7 | 0.01 | 23277 | gtex_brain_putamen_basal |
| rs8111947 | 19 | 48801426 | CCDC114 | ENSG00000105479.11 | 5.275E-7 | 0.01 | 22642 | gtex_brain_putamen_basal |
| rs7258665 | 19 | 48803482 | CCDC114 | ENSG00000105479.11 | 2.116E-7 | 0.01 | 20586 | gtex_brain_putamen_basal |
| rs10416232 | 19 | 48808851 | CCDC114 | ENSG00000105479.11 | 1.747E-7 | 0.01 | 15217 | gtex_brain_putamen_basal |
| rs249368 | 19 | 48817195 | CCDC114 | ENSG00000105479.11 | 1.168E-7 | 0.01 | 6873 | gtex_brain_putamen_basal |
| rs249372 | 19 | 48818072 | CCDC114 | ENSG00000105479.11 | 1.168E-7 | 0.01 | 5996 | gtex_brain_putamen_basal |
| rs249374 | 19 | 48819659 | CCDC114 | ENSG00000105479.11 | 1.168E-7 | 0.01 | 4409 | gtex_brain_putamen_basal |
| rs249376 | 19 | 48820447 | CCDC114 | ENSG00000105479.11 | 1.168E-7 | 0.01 | 3621 | gtex_brain_putamen_basal |
| rs249377 | 19 | 48820934 | CCDC114 | ENSG00000105479.11 | 5.277E-7 | 0.01 | 3134 | gtex_brain_putamen_basal |
| rs249378 | 19 | 48821345 | CCDC114 | ENSG00000105479.11 | 1.168E-7 | 0.01 | 2723 | gtex_brain_putamen_basal |
| rs156674 | 19 | 48822529 | CCDC114 | ENSG00000105479.11 | 1.168E-7 | 0.01 | 1539 | gtex_brain_putamen_basal |
| rs275578 | 19 | 48847519 | CCDC114 | ENSG00000105479.11 | 5.754E-7 | 0.01 | -23451 | gtex_brain_putamen_basal |
| rs275579 | 19 | 48847798 | CCDC114 | ENSG00000105479.11 | 1.286E-7 | 0.01 | -23730 | gtex_brain_putamen_basal |
| rs275584 | 19 | 48850913 | CCDC114 | ENSG00000105479.11 | 4.059E-7 | 0.01 | -26845 | gtex_brain_putamen_basal |
| rs579466 | 19 | 48852193 | CCDC114 | ENSG00000105479.11 | 2.622E-7 | 0.01 | -28125 | gtex_brain_putamen_basal |
| rs437358 | 19 | 48860702 | CCDC114 | ENSG00000105479.11 | 3.348E-7 | 0.01 | -36634 | gtex_brain_putamen_basal |
| rs438767 | 19 | 48863386 | CCDC114 | ENSG00000105479.11 | 1.052E-7 | 0.01 | -39318 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SENGUPTA NASOPHARYNGEAL CARCINOMA DN | 349 | 157 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 | 473 | 224 | All SZGR 2.0 genes in this pathway |
| LEIN CHOROID PLEXUS MARKERS | 103 | 61 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF ICP WITH H3K27ME3 | 206 | 108 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| MARTENS BOUND BY PML RARA FUSION | 456 | 287 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |