Summary ?
GeneID9342
SymbolSNAP29
SynonymsCEDNIK|SNAP-29
Descriptionsynaptosome associated protein 29kDa
ReferenceMIM:604202|HGNC:HGNC:11133|Ensembl:ENSG00000099940|HPRD:11968|Vega:OTTHUMG00000150765
Gene typeprotein-coding
Map location22q11.21
Pascal p-value0.23
Sherlock p-value0.271
Fetal beta-0.705
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Nucleus accumbens basal ganglia
Putamen basal ganglia
Meta
SupportEXOCYTOSIS

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CNV:YESCopy number variation studiesManual curation
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_IGenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs57598742221017148SNAP29ENSG00000099940.75.33E-70-196623gtex_brain_putamen_basal
rs57598752221017452SNAP29ENSG00000099940.75.354E-70-196319gtex_brain_putamen_basal
rs59965762221020848SNAP29ENSG00000099940.72.492E-60-192923gtex_brain_putamen_basal
rs1872991382221022539SNAP29ENSG00000099940.79.988E-100-191232gtex_brain_putamen_basal
rs1464600142221040007SNAP29ENSG00000099940.74.798E-80-173764gtex_brain_putamen_basal
rs731591972221040925SNAP29ENSG00000099940.74.975E-80-172846gtex_brain_putamen_basal
rs1925658742221042969SNAP29ENSG00000099940.74.233E-80-170802gtex_brain_putamen_basal
rs96244962221043393SNAP29ENSG00000099940.74.06E-80-170378gtex_brain_putamen_basal
rs1507137722221045147SNAP29ENSG00000099940.73.275E-80-168624gtex_brain_putamen_basal
rs40522612221051683SNAP29ENSG00000099940.74.825E-70-162088gtex_brain_putamen_basal
rs2015681322221051843SNAP29ENSG00000099940.78.551E-90-161928gtex_brain_putamen_basal
rs57517572221052990SNAP29ENSG00000099940.78.057E-90-160781gtex_brain_putamen_basal
rs413072432221053952SNAP29ENSG00000099940.79.695E-90-159819gtex_brain_putamen_basal
rs57601272221059531SNAP29ENSG00000099940.72.197E-70-154240gtex_brain_putamen_basal
rs134712221062268SNAP29ENSG00000099940.71.207E-70-151503gtex_brain_putamen_basal
rs57601382221062697SNAP29ENSG00000099940.71.162E-70-151074gtex_brain_putamen_basal
rs1465463352221064120SNAP29ENSG00000099940.75.911E-70-149651gtex_brain_putamen_basal
rs1133569652221065201SNAP29ENSG00000099940.71.332E-80-148570gtex_brain_putamen_basal
rs59966532221065550SNAP29ENSG00000099940.74.835E-90-148221gtex_brain_putamen_basal
rs731592002221067984SNAP29ENSG00000099940.71.281E-80-145787gtex_brain_putamen_basal
rs1484586892221068025SNAP29ENSG00000099940.71.281E-80-145746gtex_brain_putamen_basal
rs120538072221068130SNAP29ENSG00000099940.71.281E-80-145641gtex_brain_putamen_basal
rs57601672221068850SNAP29ENSG00000099940.71.004E-80-144921gtex_brain_putamen_basal
rs57601712221069951SNAP29ENSG00000099940.71.03E-80-143820gtex_brain_putamen_basal
rs731592022221073281SNAP29ENSG00000099940.71.711E-80-140490gtex_brain_putamen_basal
rs60040602221080404SNAP29ENSG00000099940.72.166E-80-133367gtex_brain_putamen_basal
rs57602072221080548SNAP29ENSG00000099940.71.317E-80-133223gtex_brain_putamen_basal
rs1135695562221090646SNAP29ENSG00000099940.71.894E-80-123125gtex_brain_putamen_basal
rs1117411252221092217SNAP29ENSG00000099940.71.33E-80-121554gtex_brain_putamen_basal
rs60041022221092244SNAP29ENSG00000099940.71.33E-80-121527gtex_brain_putamen_basal
rs1126575402221097805SNAP29ENSG00000099940.71.33E-80-115966gtex_brain_putamen_basal
.2221102197SNAP29ENSG00000099940.71.359E-80-111574gtex_brain_putamen_basal
rs57603382221102393SNAP29ENSG00000099940.71.364E-80-111378gtex_brain_putamen_basal
rs57603432221102830SNAP29ENSG00000099940.71.364E-80-110941gtex_brain_putamen_basal
rs169887642221105255SNAP29ENSG00000099940.71.364E-80-108516gtex_brain_putamen_basal
rs57518522221106055SNAP29ENSG00000099940.71.364E-80-107716gtex_brain_putamen_basal
rs731609842221106141SNAP29ENSG00000099940.71.364E-80-107630gtex_brain_putamen_basal
rs731609872221106665SNAP29ENSG00000099940.71.364E-80-107106gtex_brain_putamen_basal
rs731609892221107809SNAP29ENSG00000099940.71.364E-80-105962gtex_brain_putamen_basal
rs57603802221108125SNAP29ENSG00000099940.71.364E-80-105646gtex_brain_putamen_basal
rs1117127012221109168SNAP29ENSG00000099940.71.364E-80-104603gtex_brain_putamen_basal
rs57604172221113793SNAP29ENSG00000099940.71.41E-80-99978gtex_brain_putamen_basal
rs57518752221114200SNAP29ENSG00000099940.71.364E-80-99571gtex_brain_putamen_basal
rs731609952221115062SNAP29ENSG00000099940.71.364E-80-98709gtex_brain_putamen_basal
rs57604372221116594SNAP29ENSG00000099940.71.364E-80-97177gtex_brain_putamen_basal
rs1113467572221117639SNAP29ENSG00000099940.71.364E-80-96132gtex_brain_putamen_basal
rs99175852221118650SNAP29ENSG00000099940.71.364E-80-95121gtex_brain_putamen_basal
rs731610002221119995SNAP29ENSG00000099940.71.364E-80-93776gtex_brain_putamen_basal
rs1124724412221122005SNAP29ENSG00000099940.71.089E-70-91766gtex_brain_putamen_basal
rs120538112221125075SNAP29ENSG00000099940.71.118E-70-88696gtex_brain_putamen_basal
rs57518982221127335SNAP29ENSG00000099940.71.392E-80-86436gtex_brain_putamen_basal
rs57605132221132931SNAP29ENSG00000099940.71.364E-80-80840gtex_brain_putamen_basal
rs731628102221136259SNAP29ENSG00000099940.71.364E-80-77512gtex_brain_putamen_basal
rs57605312221136455SNAP29ENSG00000099940.71.364E-80-77316gtex_brain_putamen_basal
rs731628122221137130SNAP29ENSG00000099940.71.364E-80-76641gtex_brain_putamen_basal
rs57519392221139242SNAP29ENSG00000099940.71.364E-80-74529gtex_brain_putamen_basal
rs57519702221145242SNAP29ENSG00000099940.71.364E-80-68529gtex_brain_putamen_basal
rs678431182221145505SNAP29ENSG00000099940.71.364E-80-68266gtex_brain_putamen_basal
rs7395232221150704SNAP29ENSG00000099940.71.123E-70-63067gtex_brain_putamen_basal
rs57606782221151157SNAP29ENSG00000099940.71.364E-80-62614gtex_brain_putamen_basal
rs57606882221152568SNAP29ENSG00000099940.71.364E-80-61203gtex_brain_putamen_basal
rs57606972221154750SNAP29ENSG00000099940.71.364E-80-59021gtex_brain_putamen_basal
rs57607152221160111SNAP29ENSG00000099940.71.364E-80-53660gtex_brain_putamen_basal
rs731628192221160945SNAP29ENSG00000099940.71.364E-80-52826gtex_brain_putamen_basal
rs57607282221161564SNAP29ENSG00000099940.71.364E-80-52207gtex_brain_putamen_basal
rs57607652221167184SNAP29ENSG00000099940.71.364E-80-46587gtex_brain_putamen_basal
rs57607722221168756SNAP29ENSG00000099940.71.364E-80-45015gtex_brain_putamen_basal
rs731628252221175309SNAP29ENSG00000099940.71.364E-80-38462gtex_brain_putamen_basal
rs57608222221176629SNAP29ENSG00000099940.71.364E-80-37142gtex_brain_putamen_basal
rs57608582221180811SNAP29ENSG00000099940.71.364E-80-32960gtex_brain_putamen_basal
rs3615382221183881SNAP29ENSG00000099940.71.364E-80-29890gtex_brain_putamen_basal
rs1170222162221185753SNAP29ENSG00000099940.71.364E-80-28018gtex_brain_putamen_basal
rs731628292221186750SNAP29ENSG00000099940.71.12E-70-27021gtex_brain_putamen_basal
rs57608992221188964SNAP29ENSG00000099940.71.364E-80-24807gtex_brain_putamen_basal
rs57520772221189429SNAP29ENSG00000099940.71.364E-80-24342gtex_brain_putamen_basal
rs3622232221190377SNAP29ENSG00000099940.71.663E-80-23394gtex_brain_putamen_basal
rs57609102221191242SNAP29ENSG00000099940.71.364E-80-22529gtex_brain_putamen_basal
rs57520862221193365SNAP29ENSG00000099940.79.908E-90-20406gtex_brain_putamen_basal
.2221198229SNAP29ENSG00000099940.71.364E-80-15542gtex_brain_putamen_basal
rs57609852221199895SNAP29ENSG00000099940.71.364E-80-13876gtex_brain_putamen_basal
rs57609942221201162SNAP29ENSG00000099940.71.364E-80-12609gtex_brain_putamen_basal
rs57610002221202005SNAP29ENSG00000099940.71.364E-80-11766gtex_brain_putamen_basal
rs57521312221203461SNAP29ENSG00000099940.75.283E-90-10310gtex_brain_putamen_basal
rs731628442221211220SNAP29ENSG00000099940.71.364E-80-2551gtex_brain_putamen_basal
rs412815792221211544SNAP29ENSG00000099940.71.364E-80-2227gtex_brain_putamen_basal
rs1121978712221212716SNAP29ENSG00000099940.73.97E-80-1055gtex_brain_putamen_basal
rs104831042221220733SNAP29ENSG00000099940.71.364E-806962gtex_brain_putamen_basal
rs57521652221221305SNAP29ENSG00000099940.71.364E-807534gtex_brain_putamen_basal
rs2006301172221226537SNAP29ENSG00000099940.71.342E-7012766gtex_brain_putamen_basal
rs169888832221229564SNAP29ENSG00000099940.71.364E-8015793gtex_brain_putamen_basal
rs57521912221233549SNAP29ENSG00000099940.71.364E-8019778gtex_brain_putamen_basal
.2221235838SNAP29ENSG00000099940.71.118E-7022067gtex_brain_putamen_basal
rs1135435162221240414SNAP29ENSG00000099940.71.385E-8026643gtex_brain_putamen_basal
rs1137687452221241485SNAP29ENSG00000099940.71.364E-8027714gtex_brain_putamen_basal
rs31717412221242247SNAP29ENSG00000099940.71.364E-8028476gtex_brain_putamen_basal
rs57522012221244229SNAP29ENSG00000099940.71.364E-8030458gtex_brain_putamen_basal
rs121632062221246557SNAP29ENSG00000099940.71.118E-7032786gtex_brain_putamen_basal
rs121627032221246902SNAP29ENSG00000099940.71.364E-8033131gtex_brain_putamen_basal
rs779482032221249165SNAP29ENSG00000099940.71.364E-8035394gtex_brain_putamen_basal
rs57611952221249705SNAP29ENSG00000099940.71.118E-7035934gtex_brain_putamen_basal
rs57612592221252585SNAP29ENSG00000099940.71.364E-8038814gtex_brain_putamen_basal
rs57522292221254167SNAP29ENSG00000099940.71.352E-8040396gtex_brain_putamen_basal
rs731628662221255420SNAP29ENSG00000099940.71.368E-8041649gtex_brain_putamen_basal
rs1132171192221255863SNAP29ENSG00000099940.71.364E-8042092gtex_brain_putamen_basal
rs57613232221263577SNAP29ENSG00000099940.71.364E-8049806gtex_brain_putamen_basal
rs731628742221268433SNAP29ENSG00000099940.71.118E-7054662gtex_brain_putamen_basal
rs57613352221268733SNAP29ENSG00000099940.71.364E-8054962gtex_brain_putamen_basal
rs731628762221273196SNAP29ENSG00000099940.71.364E-8059425gtex_brain_putamen_basal
rs57522612221275053SNAP29ENSG00000099940.71.364E-8061282gtex_brain_putamen_basal
rs731628812221278298SNAP29ENSG00000099940.71.395E-8064527gtex_brain_putamen_basal
rs1132572642221281426SNAP29ENSG00000099940.71.364E-8067655gtex_brain_putamen_basal
rs2005678002221286943SNAP29ENSG00000099940.71.123E-7073172gtex_brain_putamen_basal
rs19780982221288871SNAP29ENSG00000099940.71.364E-8075100gtex_brain_putamen_basal
rs57614292221293653SNAP29ENSG00000099940.76.918E-9079882gtex_brain_putamen_basal
rs57614332221294414SNAP29ENSG00000099940.71.364E-8080643gtex_brain_putamen_basal
rs57614602221297251SNAP29ENSG00000099940.71.118E-7083480gtex_brain_putamen_basal
rs57614642221298018SNAP29ENSG00000099940.71.123E-7084247gtex_brain_putamen_basal
rs3679898112221298692SNAP29ENSG00000099940.71.364E-8084921gtex_brain_putamen_basal
rs20237152221300844SNAP29ENSG00000099940.72.426E-8087073gtex_brain_putamen_basal
rs57615202221312889SNAP29ENSG00000099940.71.782E-8099118gtex_brain_putamen_basal
rs1445548472221313072SNAP29ENSG00000099940.72.066E-8099301gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MRPL210.860.82
MRPL220.840.77
SUCLG10.840.83
HBXIP0.840.80
NDUFA120.830.83
PSMA60.820.79
ATP5O0.820.84
HAX10.820.79
RBX10.820.82
GTF3A0.810.76
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MYH9-0.50-0.49
TENC1-0.47-0.55
SEMA3G-0.47-0.51
PEAR1-0.46-0.51
DOCK6-0.46-0.52
FAM38A-0.45-0.53
MMRN2-0.45-0.46
MTSS1L-0.45-0.49
ENG-0.45-0.49
GPR124-0.44-0.49

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005484SNAP receptor activityTAS10839363 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006944membrane fusionTAS10839363 
GO:0006903vesicle targetingTAS9852078 
GO:0006887exocytosisTAS10839363 
GO:0015031protein transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneTAS9852078 
GO:0030054cell junctionIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP2A1ADTAA | AP2-ALPHA | CLAPA1adaptor-related protein complex 2, alpha 1 subunit-HPRD11423532 
C1orf190FLJ25163chromosome 1 open reading frame 190Two-hybridBioGRID16189514 
CD7GP40 | LEU-9 | TP41 | Tp40CD7 molecule-HPRD9852078 |11423532 
EHD1FLJ42622 | FLJ44618 | H-PAST | HPAST1 | PAST | PAST1EH-domain containing 1EHD1 interacts with SNAP29.BIND11423532 
EHD1FLJ42622 | FLJ44618 | H-PAST | HPAST1 | PAST | PAST1EH-domain containing 1-HPRD,BioGRID11423532 
EHD3PAST3EH-domain containing 3EHD3 interacts with SNAP29. This interaction was modeled on a demonstrated interaction between mouse EHD3 and human SNAP29.BIND11423532 
EHD3PAST3EH-domain containing 3Two-hybridBioGRID11423532 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1ER interacts with SNAP29.BIND16009131 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptor-HPRD,BioGRID11423532 
SNAP29CEDNIK | FLJ21051 | SNAP-29synaptosomal-associated protein, 29kDaSNAP29 homodimerzes.BIND11423532 
SNAP29CEDNIK | FLJ21051 | SNAP-29synaptosomal-associated protein, 29kDaTwo-hybridBioGRID11423532 
STX12MGC51957 | STX13 | STX14syntaxin 12-HPRD,BioGRID9852078 
STX17FLJ20651 | MGC102796 | MGC126613 | MGC126615syntaxin 17-HPRD,BioGRID9852078 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)-HPRD,BioGRID9852078 
STX3STX3Asyntaxin 3-HPRD,BioGRID9852078 
STX4STX4A | p35-2syntaxin 4Reconstituted ComplexBioGRID9852078 
STX6-syntaxin 6-HPRD9880331 |11423532 
STX7-syntaxin 7-HPRD,BioGRID9852078 |11423532 
VAMP7SYBL1 | TI-VAMP | VAMP-7vesicle-associated membrane protein 7-HPRD,BioGRID12853575 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG SNARE INTERACTIONS IN VESICULAR TRANSPORT 3825All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214139All SZGR 2.0 genes in this pathway
DING LUNG CANCER EXPRESSION BY COPY NUMBER 10062All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246152All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP 14094All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428246All SZGR 2.0 genes in this pathway