Gene Page: NDST3

Summary ?
GeneID9348
SymbolNDST3
SynonymsHSST3
DescriptionN-deacetylase/N-sulfotransferase 3
ReferenceMIM:603950|HGNC:HGNC:7682|Ensembl:ENSG00000164100|Vega:OTTHUMG00000132959
Gene typeprotein-coding
Map location4q26
Pascal p-value3.839E-4
Sherlock p-value0.785
Fetal beta-0.434
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
ExpressionMeta-analysis of gene expressionP value: 1.959 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17029291chr332402138NDST393488.465E-6trans
rs830202chr3165654796NDST393480.19trans
rs7894597chr109384581NDST393480.13trans
rs1324669chr13107872446NDST393480.07trans
rs17145698chrX40218345NDST393480.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LPAR60.740.68
LY960.740.60
AL050337.10.710.52
AL138743.20.700.57
CGRRF10.700.68
SPDYA0.690.34
ACOT130.690.70
IMMP1L0.680.69
MTCP1NB0.680.66
SCRG10.680.59
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TNKS1BP1-0.54-0.55
MYO18A-0.52-0.48
FAM129B-0.52-0.61
CLIP2-0.52-0.53
CADM4-0.51-0.52
SMG6-0.51-0.49
PHACTR3-0.50-0.48
DHX37-0.50-0.51
WDR81-0.50-0.47
SUPT6H-0.50-0.47

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016787hydrolase activityIEA-
GO:0016740transferase activityIEA-
GO:0008146sulfotransferase activityIEA-
GO:0015016[heparan sulfate]-glucosamine N-sulfotransferase activityIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneIEA-
GO:0005794Golgi apparatusIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE 2616All SZGR 2.0 genes in this pathway
REACTOME HS GAG BIOSYNTHESIS 3117All SZGR 2.0 genes in this pathway
REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM 5233All SZGR 2.0 genes in this pathway
REACTOME GLYCOSAMINOGLYCAN METABOLISM 11169All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247154All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353226All SZGR 2.0 genes in this pathway