Gene Page: ZFYVE9

Summary
GeneID  9372
Symbol  ZFYVE9
Synonyms  MADHIP|NSP|SARA|SMADIP
Description  zinc finger, FYVE domain containing 9
See related  HGNC:6775|MIM:603755|Ensembl:ENSG00000157077|HPRD:04782|
Locus tag  -
Gene type  protein-coding
Map location  1p32.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
COPG0.910.89
GTF3C10.900.90
ADD10.900.89
SCFD20.900.88
UBE4B0.900.90
ABCF20.900.88
SUPT6H0.890.89
EPS15L10.890.88
BTN2A10.890.86
METTL130.890.86
Top 10 negatively co-expressed genes
AF347015.31-0.78-0.76
AF347015.21-0.78-0.78
MT-CO2-0.78-0.76
HIGD1B-0.76-0.75
IFI27-0.74-0.75
FXYD1-0.74-0.75
AF347015.8-0.73-0.73
S100A16-0.73-0.75
AF347015.33-0.73-0.71
C1orf54-0.73-0.77
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008236serine-type peptidase activityNASglutamate (GO term level: 6)9582421 
GO:0004872receptor activityIEA-
GO:0005515protein bindingEXP9865696 
GO:0005515protein bindingIPI12809483 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007184SMAD protein nuclear translocationTAS9865696 
GO:0007183SMAD protein complex assemblyTAS9865696 
GO:0007181transforming growth factor beta receptor complex assemblyTAS9865696 
GO:0006897endocytosisNAS12809483 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9865696 |11100470 
GO:0005737cytoplasmNAS-
GO:0005769early endosomeNAS12809483 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
LRP12DKFZp781F1053 | FLJ12929 | ST7low density lipoprotein-related protein 12-HPRD12809483 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD,BioGRID15356634 
cPML interacts with SARA.BIND15356634 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID9865696 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD,BioGRID9865696 
ST7DKFZp762O2113 | ETS7q | FAM4A | FAM4A1 | HELG | RAY1 | SEN4 | TSG7suppression of tumorigenicity 7Affinity Capture-Western
Two-hybrid		BioGRID12809483 
TGFBR1AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1transforming growth factor, beta receptor 1-HPRD9865696 
TGFBR2AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RIItransforming growth factor, beta receptor II (70/80kDa)-HPRD9865696 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/3016369m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-14574811A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-153197203m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d65721A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-196268m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-22224230m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-49591971Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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