Gene Page: TM9SF2

Summary ?
GeneID9375
SymbolTM9SF2
SynonymsP76
Descriptiontransmembrane 9 superfamily member 2
ReferenceMIM:604678|HGNC:HGNC:11865|Ensembl:ENSG00000125304|HPRD:09198|Vega:OTTHUMG00000017272
Gene typeprotein-coding
Map location13q32.3
Pascal p-value0.722
Sherlock p-value0.128
Fetal beta0.967
DMG1 (# studies)
eGeneCerebellar Hemisphere

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg2645557913100153786TM9SF23.41E-8-0.0051.01E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GAB10.810.83
TMTC20.810.84
M6PRBP10.800.82
MEGF100.800.82
RFTN20.790.83
LASS20.790.84
CA140.780.77
MAGT10.780.82
COL4A50.780.82
PRR5L0.780.83
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KLHL1-0.39-0.25
MPPED1-0.34-0.25
NEUROD6-0.34-0.28
DACT1-0.34-0.20
SATB2-0.33-0.22
RP9P-0.33-0.44
AC011491.1-0.33-0.38
IER5L-0.33-0.24
MEF2C-0.32-0.25
RPRM-0.32-0.27

Section III. Gene Ontology annotation

Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006810transportTAS9729438 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005768endosomeTAS9729438 
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS9729438 
GO:0010008endosome membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372227All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS UP 2814All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
TOMLINS METASTASIS DN 2016All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE UP 7851All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO MERCAPTOPURINE AND LD MTX UP 106All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457302All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668419All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN 193112All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN 14688All SZGR 2.0 genes in this pathway