Gene Page: SLC22A8
Summary ?
| GeneID | 9376 |
| Symbol | SLC22A8 |
| Synonyms | OAT3 |
| Description | solute carrier family 22 member 8 |
| Reference | MIM:607581|HGNC:HGNC:10972|Ensembl:ENSG00000149452|Vega:OTTHUMG00000167768 |
| Gene type | protein-coding |
| Map location | 11q11 |
| Pascal p-value | 0.356 |
| Fetal beta | -0.101 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SLC12A2 | 0.91 | 0.87 |
| MOSPD2 | 0.88 | 0.81 |
| ATP11A | 0.87 | 0.88 |
| MAN2A1 | 0.87 | 0.83 |
| SECISBP2L | 0.87 | 0.88 |
| ZDHHC20 | 0.86 | 0.83 |
| FAR1 | 0.86 | 0.89 |
| C21orf91 | 0.86 | 0.82 |
| ERMP1 | 0.85 | 0.76 |
| MYO1D | 0.85 | 0.78 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C1orf61 | -0.44 | -0.54 |
| ST20 | -0.41 | -0.49 |
| IL32 | -0.40 | -0.46 |
| AC006276.2 | -0.40 | -0.42 |
| RPL35 | -0.39 | -0.45 |
| AC016757.1 | -0.38 | -0.39 |
| PFDN5 | -0.38 | -0.39 |
| RP9P | -0.37 | -0.43 |
| AC087071.1 | -0.37 | -0.41 |
| HES4 | -0.36 | -0.42 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 413 | 270 | All SZGR 2.0 genes in this pathway |
| REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT | 241 | 157 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | 89 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | 13 | 9 | All SZGR 2.0 genes in this pathway |