Gene Page: LRRC4B
Summary ?
| GeneID | 94030 |
| Symbol | LRRC4B |
| Synonyms | HSM|LRIG4 |
| Description | leucine rich repeat containing 4B |
| Reference | HGNC:HGNC:25042|Ensembl:ENSG00000131409| |
| Gene type | protein-coding |
| Map location | 19q13.33 |
| Pascal p-value | 0.007 |
| Fetal beta | -0.353 |
| eGene | Cortex |
| Support | CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RAB1A | 0.88 | 0.88 |
| SRP54 | 0.87 | 0.88 |
| RAB11A | 0.87 | 0.88 |
| MED4 | 0.86 | 0.86 |
| RCHY1 | 0.86 | 0.85 |
| AL356863.2 | 0.84 | 0.84 |
| ZC3H15 | 0.84 | 0.85 |
| PPHLN1 | 0.84 | 0.82 |
| MORF4L1 | 0.84 | 0.82 |
| FBXO3 | 0.84 | 0.83 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.67 | -0.66 |
| AF347015.33 | -0.65 | -0.66 |
| AF347015.2 | -0.65 | -0.67 |
| AF347015.31 | -0.64 | -0.66 |
| AF347015.8 | -0.64 | -0.65 |
| MT-CYB | -0.64 | -0.65 |
| AF347015.15 | -0.63 | -0.66 |
| AF347015.27 | -0.62 | -0.64 |
| FXYD1 | -0.62 | -0.65 |
| AF347015.21 | -0.61 | -0.60 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| MIKKELSEN MEF ICP WITH H3K27ME3 | 206 | 108 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K27ME3 | 42 | 27 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC ICP WITH H3K4ME3 | 445 | 257 | All SZGR 2.0 genes in this pathway |