Summary ?
GeneID9420
SymbolCYP7B1
SynonymsCBAS3|CP7B|SPG5A
Descriptioncytochrome P450 family 7 subfamily B member 1
ReferenceMIM:603711|HGNC:HGNC:2652|Ensembl:ENSG00000172817|HPRD:04753|Vega:OTTHUMG00000164387
Gene typeprotein-coding
Map location8q21.3
Pascal p-value0.017

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C2orf440.950.94
RQCD10.950.95
YTHDF20.940.93
BUB30.930.95
C17orf710.930.94
GPN10.930.93
LCMT20.930.94
GART0.930.90
C12orf410.930.93
ALDH18A10.930.92
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.76-0.90
AF347015.33-0.76-0.90
AF347015.31-0.75-0.88
AF347015.27-0.75-0.88
MT-CYB-0.74-0.89
AF347015.8-0.74-0.91
HLA-F-0.73-0.78
FXYD1-0.73-0.87
AIFM3-0.72-0.79
AF347015.15-0.72-0.88

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PRIMARY BILE ACID BIOSYNTHESIS 169All SZGR 2.0 genes in this pathway
KEGG STEROID HORMONE BIOSYNTHESIS 5530All SZGR 2.0 genes in this pathway
REACTOME BILE ACID AND BILE SALT METABOLISM 2711All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS 199All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 13991All SZGR 2.0 genes in this pathway
REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE 5134All SZGR 2.0 genes in this pathway
REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS 7050All SZGR 2.0 genes in this pathway
REACTOME ENDOGENOUS STEROLS 1510All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS E UP 9760All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS UP 201127All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN 6643All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN 6544All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 DN 6539All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 DN 6438All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 7445All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN 234137All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302191All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS UP 3727All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428266All SZGR 2.0 genes in this pathway
WENG POR TARGETS GLOBAL DN 2314All SZGR 2.0 genes in this pathway
WENG POR TARGETS LIVER DN 2011All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
ALONSO METASTASIS DN 2617All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D DN 4934All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 DN 4026All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL DN 7651All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 4 UP 11264All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 14985All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448282All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN 157105All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244157All SZGR 2.0 genes in this pathway