Summary ?
GeneID9439
SymbolMED23
SynonymsARC130|CRSP130|CRSP133|CRSP3|DRIP130|MRT18|SUR-2|SUR2
Descriptionmediator complex subunit 23
ReferenceMIM:605042|HGNC:HGNC:2372|Ensembl:ENSG00000112282|HPRD:05436|Vega:OTTHUMG00000015565
Gene typeprotein-coding
Map location6q22.33-q24.1
Pascal p-value0.101
Fetal beta0.651
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg055279186131949098MED234.06E-9-0.0122.49E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs11120206chr1206610593MED2394390.03trans
rs2716734chr239947720MED2394390.14trans
rs2716736chr239947946MED2394390.14trans
rs11754465chr611761260MED2394390.01trans
rs16893142chr8127104392MED2394390.19trans
rs12255258chr10106306927MED2394398.841E-4trans
rs6128541chr2057917688MED2394390.08trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SYNJ10.950.93
GABRG20.950.93
NCOA70.950.92
GLS0.950.93
ATP6V1A0.940.92
FAM179B0.940.88
PIK3CB0.930.94
NSF0.930.90
ARFGEF20.930.89
MAP2K40.930.92
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
EFEMP2-0.47-0.53
RAB34-0.47-0.57
C1orf61-0.44-0.59
IRF7-0.43-0.56
GATSL3-0.42-0.46
AL022328.1-0.42-0.53
DBI-0.41-0.47
AC006276.2-0.41-0.41
CLEC3B-0.41-0.52
RAB13-0.41-0.50

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003713transcription coactivator activityTAS9989412 
GO:0005515protein bindingIPI17438371 
GO:0030528transcription regulator activityIDA9989412 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006367transcription initiation from RNA polymerase II promoterTAS9989412 
GO:0006357regulation of transcription from RNA polymerase II promoterTAS9989412 
GO:0006350transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005667transcription factor complexIDA9989412 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetAffinity Capture-MSBioGRID15208681 
CDK8K35 | MGC126074 | MGC126075cyclin-dependent kinase 8Affinity Capture-WesternBioGRID11416138 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD,BioGRID14759369 
ELF3EPR-1 | ERT | ESE-1 | ESXE74-like factor 3 (ets domain transcription factor, epithelial-specific )-HPRD,BioGRID12242338 
FOXJ3MGC165036 | MGC176686forkhead box J3-HPRD12421765 
HNF4AFLJ39654 | HNF4 | HNF4a7 | HNF4a8 | HNF4a9 | MODY | MODY1 | NR2A1 | NR2A21 | TCF | TCF14hepatocyte nuclear factor 4, alphaAffinity Capture-WesternBioGRID12089346 
IRF1IRF-1 | MARinterferon regulatory factor 1An unspecified isoform of MED23 interacts with IRF-1 promoter.BIND15893730 
MED10L6 | MGC5309 | NUT2 | TRG20mediator complex subunit 10Affinity Capture-MSBioGRID15175163 
MED19DT2P1G7 | LCMR1mediator complex subunit 19Affinity Capture-MSBioGRID15175163 
MED26CRSP7 | CRSP70mediator complex subunit 26Affinity Capture-MSBioGRID15175163 
MED281500003D12Rik | DKFZp434N185 | EG1 | magicinmediator complex subunit 28Affinity Capture-MSBioGRID15175163 
MED29DKFZp434H247 | IXLmediator complex subunit 29-HPRD14576168 
MED29DKFZp434H247 | IXLmediator complex subunit 29Affinity Capture-MSBioGRID15175163 
MED9FLJ10193 | MED25 | MGC138234mediator complex subunit 9-HPRD14638676 
MED9FLJ10193 | MED25 | MGC138234mediator complex subunit 9Affinity Capture-MSBioGRID15175163 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6-HPRD,BioGRID10823961 
WDTC1ADP | KIAA1037 | RP11-4K3__A.1WD and tetratricopeptide repeats 1-HPRD12421765 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION 10472All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352181All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168115All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7253All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805505All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206118All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
MA PITUITARY FETAL VS ADULT DN 1917All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 12589All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A UP 10457All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BILANGES RAPAMYCIN SENSITIVE GENES 3920All SZGR 2.0 genes in this pathway